Glycyrrhetinic acid

Glycyrrhetinic acid is a lipid of Prenol Lipids (PR) class. Glycyrrhetinic acid is associated with abnormalities such as Congenital Abnormality, Cortisol 11-beta-ketoreductase deficiency, Hypertensive disease, Mineralocorticoid Excess Syndrome, Apparent and Syndrome. The involved functions are known as Signal, Muscle Contraction, Pressure- physical agent, Agent and Metabolic Inhibition. Glycyrrhetinic acid often locates in Protoplasm, Body tissue, Muscle, Connexon and Extracellular. The associated genes with Glycyrrhetinic acid are SLC33A1 gene, GJB1 gene, RNU1-1 gene, HADHA gene and RNU1-4 gene. The related lipids are Steroids, Saponin, Octanols, Heptanol and amyrin.

References related to lipids published in Others

PMID	Journal	Published Date	Author	Title
11259395	FASEB J.	2001	Oviedo-Orta E et al.	Immunoglobulin and cytokine expression in mixed lymphocyte cultures is reduced by disruption of gap junction intercellular communication.
11748079	Am. J. Physiol. Heart Circ. Physiol.	2002	Tare M et al.	Glycyrrhetinic derivatives inhibit hyperpolarization in endothelial cells of guinea pig and rat arteries.
11756680	Proc. Natl. Acad. Sci. U.S.A.	2002	Contreras JE et al.	Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture.
11997239	Am. J. Physiol., Cell Physiol.	2002	Kolomytkin OV et al.	IL-1beta-induced production of metalloproteinases by synovial cells depends on gap junction conductance.
15528254	Am. J. Physiol. Gastrointest. Liver Physiol.	2005	Takeda Y et al.	Effects of the gap junction blocker glycyrrhetinic acid on gastrointestinal smooth muscle cells.
16002718	J. Immunol.	2005	Ukil A et al.	18 Beta-glycyrrhetinic acid triggers curative Th1 response and nitric oxide up-regulation in experimental visceral leishmaniasis associated with the activation of NF-kappa B.
25691644	Antimicrob. Agents Chemother.	2015	Gupta P et al.	Antileishmanial effect of 18β-glycyrrhetinic acid is mediated by Toll-like receptor-dependent canonical and noncanonical p38 activation.