sphingosylphosphorylcholine

sphingosylphosphorylcholine is a lipid of Sphingolipids (SP) class. Sphingosylphosphorylcholine is associated with abnormalities such as Cerebral Vasospasm, Subarachnoid Hemorrhage, Atherosclerosis, Hypertensive disease and Niemann-Pick Diseases. The involved functions are known as MAP kinase kinase activity, JUN kinase activity, Phosphorylation, biphenyl synthase activity and Cell Death. Sphingosylphosphorylcholine often locates in Adipose tissue, Protoplasm, Body tissue, Membrane and Extracellular. The associated genes with sphingosylphosphorylcholine are UCN3 gene, MAPK9 gene, JUN gene, NAA50 gene and P4HTM gene. The related lipids are Lysophospholipids, lysophosphatidic acid, Lysophosphatidylcholines, Sphingolipids and Saponin. The related experimental models are Mouse Model.

References related to lipids published in Others


PMIDJournalPublished DateAuthorTitle
21368227J. Immunol.2011Lee HY et al.Sphingosylphosphorylcholine stimulates CCL2 production from human umbilical vein endothelial cells.
17105765J. Cell. Sci.2006Jeon ES et al.Sphingosylphosphorylcholine induces differentiation of human mesenchymal stem cells into smooth-muscle-like cells through a TGF-beta-dependent mechanism.
16111665Cardiovasc. Res.2005Schubert RNon-capacitative calcium entry--extension of the possibilities for calcium entry in vascular tissue.
18523246J. Immunol.2008Takenouchi T et al.Lysophospholipids and ATP mutually suppress maturation and release of IL-1 beta in mouse microglial cells using a Rho-dependent pathway.
22344252J. Cell. Sci.2012Busch T et al.Keratin 8 phosphorylation regulates keratin reorganization and migration of epithelial tumor cells.
27402344Biochem. Pharmacol.2016Wirrig C et al.Sphingosylphosphorylcholine inhibits macrophage adhesion to vascular smooth muscle cells.
26876307Biochim. Biophys. Acta2016Lee EJ et al.Epithelial membrane protein 2 regulates sphingosylphosphorylcholine-induced keratin 8 phosphorylation and reorganization: Changes of PP2A expression by interaction with alpha4 and caveolin-1 in lung cancer cells.
25908861J. Cell. Sci.2015Hyder CL et al.Sphingolipids inhibit vimentin-dependent cell migration.