7-Ketocholesterol
7-Ketocholesterol is a lipid of Sterol Lipids (ST) class. 7-ketocholesterol is associated with abnormalities such as Atherosclerosis, Age related macular degeneration, Drusen, Cardiovascular Diseases and Hypercholesterolemia. The involved functions are known as mRNA Expression, Choroidal Neovascularization, Biochemical Pathway, Inflammation and Regulation. 7-ketocholesterol often locates in Basal lamina of choroid, Mitochondria, Epithelium, Frozen Sections and Membrane. The associated genes with 7-Ketocholesterol are ABCA1 gene, SLC33A1 gene, GAPDH gene, P4HTM gene and TSPO gene. The related lipids are Ketocholesterols, cholesterol oxide, Sterols, oxidized lipid and 7-ketocholesterol. The related experimental models are Knock-out and Mouse Model.
References related to lipids published in Others
| PMID | Journal | Published Date | Author | Title |
|---|---|---|---|---|
| 9837855 | FASEB J. | 1998 | Lizard G et al. | Glutathione is implied in the control of 7-ketocholesterol-induced apoptosis, which is associated with radical oxygen species production. |
| 15364622 | Cardiovasc. Res. | 2004 | Seye CI et al. | 7-Ketocholesterol induces reversible cytochrome c release in smooth muscle cells in absence of mitochondrial swelling. |
| 18936140 | Invest. Ophthalmol. Vis. Sci. | 2009 | Moreira EF et al. | 7-Ketocholesterol is present in lipid deposits in the primate retina: potential implication in the induction of VEGF and CNV formation. |
| 20554621 | Invest. Ophthalmol. Vis. Sci. | 2010 | Larrayoz IM et al. | 7-ketocholesterol-induced inflammation: involvement of multiple kinase signaling pathways via NFκB but independently of reactive oxygen species formation. |
| 17846428 | Proc. Natl. Acad. Sci. U.S.A. | 2007 | Terasaka N et al. | High-density lipoprotein protects macrophages from oxidized low-density lipoprotein-induced apoptosis by promoting efflux of 7-ketocholesterol via ABCG1. |
| 24028627 | FEMS Yeast Res. | 2013 | Yue Q et al. | 7-ketocholesterol-induced caspase-mediated apoptosis in Saccharomyces cerevisiae. |
| 21144857 | Front Neuroendocrinol | 2011 | Wyrwoll CS et al. | 11β-hydroxysteroid dehydrogenases and the brain: from zero to hero, a decade of progress. |
| 20443782 | Clin. Sci. | 2010 | Jarvie E et al. | Lipotoxicity in obese pregnancy and its potential role in adverse pregnancy outcome and obesity in the offspring. |
| 24371802 | Redox Biol | 2013 | Okabe A et al. | Adaptive responses induced by 24S-hydroxycholesterol through liver X receptor pathway reduce 7-ketocholesterol-caused neuronal cell death. |
| 18390616 | Biophys. J. | 2008 | Kim DH and Frangos JA | Effects of amyloid beta-peptides on the lysis tension of lipid bilayer vesicles containing oxysterols. |
| 11256965 | Biochem. J. | 2001 | Hamilton JA et al. | Enhancement of macrophage survival and DNA synthesis by oxidized-low-density-lipoprotein (LDL)-derived lipids and by aggregates of lightly oxidized LDL. |
| 26019250 | J. Nutr. | 2015 | Moinard C et al. | Citrulline Supplementation Induces Changes in Body Composition and Limits Age-Related Metabolic Changes in Healthy Male Rats. |
| 25186795 | Circ. Res. | 2014 | Rao X et al. | CD36-dependent 7-ketocholesterol accumulation in macrophages mediates progression of atherosclerosis in response to chronic air pollution exposure. |