Ergosterol is a lipid of Sterol Lipids (ST) class. Ergosterol is associated with abnormalities such as Disintegration (morphologic abnormality), Consumption-archaic term for TB, Candidiasis, Mycoses and Iodotyrosyl coupling defect. The involved functions are known as Anabolism, sporulation, 5-(carboxyamino)imidazole ribonucleotide mutase activity, Subtraction process and Physiologic Organization. Ergosterol often locates in Pore, Membrane, Protoplasm, Plasma membrane and Endoplasmic Reticulum. The associated genes with Ergosterol are IMPACT gene, BLVRB gene, CYP51A1 gene, CDR1 wt Allele and HM13 gene. The related lipids are Sterols, Cardiolipins, Membrane Lipids, fecosterol and Phosphatidylserines. The related experimental models are Knock-out.
PMID | Journal | Published Date | Author | Title |
---|---|---|---|---|
9851052 | FEMS Microbiol. Lett. | 1998 | Swan TM and Watson K | Stress tolerance in a yeast sterol auxotroph: role of ergosterol, heat shock proteins and trehalose. |
10224154 | J. Lipid Res. | 1999 | Dimster-Denk D et al. | Comprehensive evaluation of isoprenoid biosynthesis regulation in Saccharomyces cerevisiae utilizing the Genome Reporter Matrix. |
9705415 | J. Clin. Microbiol. | 1998 | Vazquez JA et al. | Stable phenotypic resistance of Candida species to amphotericin B conferred by preexposure to subinhibitory levels of azoles. |
10488201 | J. Clin. Microbiol. | 1999 | Arthington-Skaggs BA et al. | Quantitation of ergosterol content: novel method for determination of fluconazole susceptibility of Candida albicans. |
10234823 | FEMS Microbiol. Lett. | 1999 | Opekarová M et al. | Expression of eukaryotic plasma membrane transporter HUP1 from Chlorella kessleri in Escherichia coli. |
11238399 | Genetics | 2001 | Beh CT et al. | Overlapping functions of the yeast oxysterol-binding protein homologues. |
11160377 | J. Lipid Res. | 2001 | Gachotte D et al. | A novel gene conserved from yeast to humans is involved in sterol biosynthesis. |
11679327 | Appl. Environ. Microbiol. | 2001 | Suberkropp K | Fungal growth, production, and sporulation during leaf decomposition in two streams. |
11483507 | EMBO J. | 2001 | Kato M and Wickner W | Ergosterol is required for the Sec18/ATP-dependent priming step of homotypic vacuole fusion. |
11489845 | J. Bacteriol. | 2001 | Jensen-Pergakes K et al. | Transcriptional regulation of the two sterol esterification genes in the yeast Saccharomyces cerevisiae. |
12145211 | EMBO J. | 2002 | Hongay C et al. | Mot3 is a transcriptional repressor of ergosterol biosynthetic genes and is required for normal vacuolar function in Saccharomyces cerevisiae. |
12788704 | Appl. Environ. Microbiol. | 2003 | Sebastian A and Larsson L | Characterization of the microbial community in indoor environments: a chemical-analytical approach. |
13129623 | FEMS Microbiol. Lett. | 2003 | Thevissen K et al. | DmAMP1, an antifungal plant defensin from dahlia (Dahlia merckii), interacts with sphingolipids from Saccharomyces cerevisiae. |
12702319 | FEMS Yeast Res. | 2002 | Kamińska J et al. | The isoprenoid biosynthetic pathway in Saccharomyces cerevisiae is affected in a maf1-1 mutant with altered tRNA synthesis. |
12702345 | FEMS Yeast Res. | 2001 | Toh TH et al. | Implications of FPS1 deletion and membrane ergosterol content for glycerol efflux from Saccharomyces cerevisiae. |
12684380 | Eukaryotic Cell | 2003 | Hand RA et al. | Saccharomyces cerevisiae Dap1p, a novel DNA damage response protein related to the mammalian membrane-associated progesterone receptor. |
12513985 | Appl. Environ. Microbiol. | 2003 | Rosenfeld E et al. | Oxygen consumption by anaerobic Saccharomyces cerevisiae under enological conditions: effect on fermentation kinetics. |
12516028 | Clin. Infect. Dis. | 2003 | Loeffler J and Stevens DA | Antifungal drug resistance. |
12477804 | Eukaryotic Cell | 2002 | Henry KW et al. | ROX1 and ERG regulation in Saccharomyces cerevisiae: implications for antifungal susceptibility. |
12902224 | Appl. Environ. Microbiol. | 2003 | Hietala AM et al. | Multiplex real-time PCR for monitoring Heterobasidion annosum colonization in Norway spruce clones that differ in disease resistance. |
12902271 | Appl. Environ. Microbiol. | 2003 | Higgins VJ et al. | Yeast genome-wide expression analysis identifies a strong ergosterol and oxidative stress response during the initial stages of an industrial lager fermentation. |
12839773 | Appl. Environ. Microbiol. | 2003 | Reeslev M et al. | Quantifying mold biomass on gypsum board: comparison of ergosterol and beta-N-acetylhexosaminidase as mold biomass parameters. |
10618221 | Appl. Environ. Microbiol. | 2000 | Newell SY et al. | Autumnal biomass and potential productivity of salt marsh fungi from 29 degrees to 43 degrees north latitude along the United States Atlantic Coast. |
10564282 | Mol. Biol. Cell | 1999 | Munn AL et al. | Specific sterols required for the internalization step of endocytosis in yeast. |
10913693 | FEMS Microbiol. Lett. | 2000 | Zeppa S et al. | Estimation of fungal biomass and transcript levels in Tilia platyphyllos-Tuber borchii ectomycorrhizae. |
10716729 | Proc. Natl. Acad. Sci. U.S.A. | 2000 | Bagnat M et al. | Lipid rafts function in biosynthetic delivery of proteins to the cell surface in yeast. |
15189988 | Eukaryotic Cell | 2004 | Martin SW and Konopka JB | Lipid raft polarization contributes to hyphal growth in Candida albicans. |
21135205 | Proc. Natl. Acad. Sci. U.S.A. | 2010 | Becker JM et al. | Pathway analysis of Candida albicans survival and virulence determinants in a murine infection model. |
21368185 | Proc. Natl. Acad. Sci. U.S.A. | 2011 | Palacios DS et al. | Synthesis-enabled functional group deletions reveal key underpinnings of amphotericin B ion channel and antifungal activities. |
21436218 | Microbiology (Reading, Engl.) | 2011 | Liu X et al. | A sterol C-14 reductase encoded by FgERG24B is responsible for the intrinsic resistance of Fusarium graminearum to amine fungicides. |
21467572 | Genetics | 2011 | Hickman MJ et al. | The Hog1 mitogen-activated protein kinase mediates a hypoxic response in Saccharomyces cerevisiae. |
20870877 | Eukaryotic Cell | 2010 | Synnott JM et al. | Regulation of the hypoxic response in Candida albicans. |
19175415 | FEMS Yeast Res. | 2009 | Verbelen PJ et al. | The influence of yeast oxygenation prior to brewery fermentation on yeast metabolism and the oxidative stress response. |
19589904 | J. Med. Microbiol. | 2009 | Pinto E et al. | Antifungal activity of the clove essential oil from Syzygium aromaticum on Candida, Aspergillus and dermatophyte species. |
19571037 | FASEB J. | 2009 | Jean-François F et al. | Selectivity of cateslytin for fungi: the role of acidic lipid-ergosterol membrane fluidity in antimicrobial action. |
19385998 | FEMS Yeast Res. | 2009 | Pinto e Silva AT et al. | Dynamics of in vitro acquisition of resistance by Candida parapsilosis to different azoles. |
20223895 | J. Med. Microbiol. | 2010 | Zheng H et al. | TOP2 gene disruption reduces drug susceptibility by increasing intracellular ergosterol biosynthesis in Candida albicans. |
20388730 | J. Cell. Sci. | 2010 | Nakase M et al. | Mannosylinositol phosphorylceramide is a major sphingolipid component and is required for proper localization of plasma-membrane proteins in Schizosaccharomyces pombe. |
20491944 | FEMS Yeast Res. | 2010 | Prasad T et al. | Morphogenic regulator EFG1 affects the drug susceptibilities of pathogenic Candida albicans. |
20150508 | Proc. Natl. Acad. Sci. U.S.A. | 2010 | Aguilar PS et al. | Structure of sterol aliphatic chains affects yeast cell shape and cell fusion during mating. |
20173071 | Appl. Environ. Microbiol. | 2010 | Stefani FO et al. | Impact of endochitinase-transformed white spruce on soil fungal biomass and ectendomycorrhizal symbiosis. |
17277172 | Eukaryotic Cell | 2007 | Márquez-Fernández O et al. | Phosphopantetheinyl transferase CfwA/NpgA is required for Aspergillus nidulans secondary metabolism and asexual development. |
22106303 | Proc. Natl. Acad. Sci. U.S.A. | 2012 | Yasmin S et al. | Mevalonate governs interdependency of ergosterol and siderophore biosyntheses in the fungal pathogen Aspergillus fumigatus. |
17981947 | Appl. Environ. Microbiol. | 2008 | Pitkäranta M et al. | Analysis of fungal flora in indoor dust by ribosomal DNA sequence analysis, quantitative PCR, and culture. |
17257373 | FEMS Yeast Res. | 2007 | Westermeyer C and Macreadie IG | Simvastatin reduces ergosterol levels, inhibits growth and causes loss of mtDNA in Candida glabrata. |
17993571 | Eukaryotic Cell | 2008 | Banerjee D et al. | Responses of pathogenic and nonpathogenic yeast species to steroids reveal the functioning and evolution of multidrug resistance transcriptional networks. |
18094052 | Mol. Biol. Cell | 2008 | Pineau L et al. | A lipid-mediated quality control process in the Golgi apparatus in yeast. |
18310042 | Microbiology (Reading, Engl.) | 2008 | Oliver BG et al. | Tetracycline alters drug susceptibility in Candida albicans and other pathogenic fungi. |
15590813 | Eukaryotic Cell | 2004 | Krantz M et al. | Anaerobicity prepares Saccharomyces cerevisiae cells for faster adaptation to osmotic shock. |
16329962 | FEMS Microbiol. Ecol. | 2005 | Taboski MA et al. | Lead and cadmium uptake in the marine fungi Corollospora lacera and Monodictys pelagica. |
16330752 | Proc. Natl. Acad. Sci. U.S.A. | 2005 | Proszynski TJ et al. | A genome-wide visual screen reveals a role for sphingolipids and ergosterol in cell surface delivery in yeast. |
16055745 | Mol. Cell. Biol. | 2005 | Davies BS et al. | Dual activators of the sterol biosynthetic pathway of Saccharomyces cerevisiae: similar activation/regulatory domains but different response mechanisms. |
16510520 | J. Exp. Bot. | 2006 | Rossard S et al. | Early changes in membrane permeability, production of oxidative burst and modification of PAL activity induced by ergosterol in cotyledons of Mimosa pudica. |
17016471 | EMBO J. | 2006 | Tafforeau L et al. | Repression of ergosterol level during oxidative stress by fission yeast F-box protein Pof14 independently of SCF. |
16757742 | Eukaryotic Cell | 2006 | Grossmann G et al. | Lipid raft-based membrane compartmentation of a plant transport protein expressed in Saccharomyces cerevisiae. |
16783004 | Genetics | 2006 | Davies BS and Rine J | A role for sterol levels in oxygen sensing in Saccharomyces cerevisiae. |
16195350 | Mol. Biol. Cell | 2005 | Kishimoto T et al. | Defects in structural integrity of ergosterol and the Cdc50p-Drs2p putative phospholipid translocase cause accumulation of endocytic membranes, onto which actin patches are assembled in yeast. |
16195452 | Science | 2005 | Cowen LE and Lindquist S | Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi. |
16135527 | Mol. Biol. Cell | 2005 | Altmann K and Westermann B | Role of essential genes in mitochondrial morphogenesis in Saccharomyces cerevisiae. |
17170709 | EMBO J. | 2007 | Grossmann G et al. | Membrane potential governs lateral segregation of plasma membrane proteins and lipids in yeast. |
18495843 | J. Cell. Sci. | 2008 | Kemper C et al. | Integration of tail-anchored proteins into the mitochondrial outer membrane does not require any known import components. |
18757808 | Microbiology (Reading, Engl.) | 2008 | Hoot SJ et al. | Candida albicans UPC2 is transcriptionally induced in response to antifungal drugs and anaerobicity through Upc2p-dependent and -independent mechanisms. |
22591742 | J. Lipid Res. | 2012 | Miller MB et al. | Evolutionarily conserved Delta(25(27))-olefin ergosterol biosynthesis pathway in the alga Chlamydomonas reinhardtii. |
22308411 | Proc. Natl. Acad. Sci. U.S.A. | 2012 | Gray KC et al. | Amphotericin primarily kills yeast by simply binding ergosterol. |
22923048 | Eukaryotic Cell | 2012 | Flowers SA et al. | Gain-of-function mutations in UPC2 are a frequent cause of ERG11 upregulation in azole-resistant clinical isolates of Candida albicans. |
22733749 | Proc. Natl. Acad. Sci. U.S.A. | 2012 | te Welscher YM et al. | Polyene antibiotic that inhibits membrane transport proteins. |
22357954 | J. Cell. Sci. | 2012 | Karunakaran S et al. | SNAREs, HOPS and regulatory lipids control the dynamics of vacuolar actin during homotypic fusion in S. cerevisiae. |
23475946 | Microbiology (Reading, Engl.) | 2013 | Kang CK et al. | Visualization analysis of the vacuole-targeting fungicidal activity of amphotericin B against the parent strain and an ergosterol-less mutant of Saccharomyces cerevisiae. |
23382196 | Proc. Natl. Acad. Sci. U.S.A. | 2013 | South PF et al. | H3K4 methyltransferase Set1 is involved in maintenance of ergosterol homeostasis and resistance to Brefeldin A. |
22904057 | Appl. Environ. Microbiol. | 2012 | Hong KK and Nielsen J | Recovery of phenotypes obtained by adaptive evolution through inverse metabolic engineering. |
15254266 | Mol. Biol. Cell | 2004 | Tedrick K et al. | Enhanced membrane fusion in sterol-enriched vacuoles bypasses the Vrp1p requirement. |
28420736 | MBio | 2017 | Qin L et al. | Deciphering the Regulatory Network between the SREBP Pathway and Protein Secretion in Neurospora crassa. |
27585850 | Genetics | 2016 | Xu YJ et al. | Hydroxyurea Induces Cytokinesis Arrest in Cells Expressing a Mutated Sterol-14α-Demethylase in the Ergosterol Biosynthesis Pathway. |
27166810 | Biophys. J. | 2016 | Hung WC et al. | Comparative Study of the Condensing Effects of Ergosterol and Cholesterol. |
26908577 | MBio | 2016 | Song J et al. | The Aspergillus fumigatus Damage Resistance Protein Family Coordinately Regulates Ergosterol Biosynthesis and Azole Susceptibility. |
26496686 | Chem. Biol. | 2015 | Leaver DJ et al. | Fluorinated Sterols Are Suicide Inhibitors of Ergosterol Biosynthesis and Growth in Trypanosoma brucei. |
26116701 | FASEB J. | 2015 | Mathur R et al. | Elevated ergosterol protects Leishmania parasites against antimony-generated stress. |
25963993 | Biochim. Biophys. Acta | 2015 | Nåbo LJ et al. | Design of new fluorescent cholesterol and ergosterol analogs: Insights from theory. |
25424002 | J. Lipid Res. | 2015 | Haubrich BA et al. | Discovery of an ergosterol-signaling factor that regulates Trypanosoma brucei growth. |
25130438 | Int. J. Biochem. Cell Biol. | 2014 | Tuckey RC et al. | Lumisterol is metabolized by CYP11A1: discovery of a new pathway. |
24627128 | J. Lipid Res. | 2014 | Fügi MA et al. | Genome profiling of sterol synthesis shows convergent evolution in parasites and guides chemotherapeutic attack. |