lysophosphatidic acid

lysophosphatidic acid is a lipid of Glycerophospholipids (GP) class. Lysophosphatidic acid is associated with abnormalities such as Atherosclerosis, Alzheimer's Disease, Asthma, Diabetes Mellitus, Non-Insulin-Dependent and Septicemia. The involved functions are known as Inflammation, Chemotaxis, Binding (Molecular Function), Polymerization and Inflammatory Response. Lysophosphatidic acid often locates in Cytoskeleton, Microfilaments, actin cytoskeleton, Extracellular and Structure of germinal center of lymph node. The associated genes with lysophosphatidic acid are TNF gene, MAPK3 gene, RHOA gene, CDC42 gene and ADRBK1 gene. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Lysophosphatidylcholines, Lysophospholipids and Phosphatidic Acid. The related experimental models are Knock-out, Transgenic Model, Rodent Model and Disease model.

References related to lipids published in Others

PMID	Journal	Published Date	Author	Title
26037280	Endocr. Relat. Cancer	2015	Benesch MG et al.	Autotaxin is an inflammatory mediator and therapeutic target in thyroid cancer.
28588064	EMBO J.	2017	Aikawa S et al.	Autotaxin-lysophosphatidic acid-LPA3 signaling at the embryo-epithelial boundary controls decidualization pathways.
27474750	J. Pharmacol. Exp. Ther.	2016	Hopkins MM et al.	Positive and Negative Cross-Talk between Lysophosphatidic Acid Receptor 1, Free Fatty Acid Receptor 4, and Epidermal Growth Factor Receptor in Human Prostate Cancer Cells.
27401461	Physiol Rep	2016	Sweat RS et al.	Lysophosphatidic acid does not cause blood/lymphatic vessel plasticity in the rat mesentery culture model.
27161483	Cell Chem Biol	2016	Hövelmann F et al.	Optotaxis: Caged Lysophosphatidic Acid Enables Optical Control of a Chemotactic Gradient.
27142833	J. Cell. Sci.	2016	Ferru-Clément R et al.	Targeting surface voids to counter membrane disorders in lipointoxication-related diseases.
27030671	Mol. Biol. Cell	2016	Bartolini F et al.	An mDia1-INF2 formin activation cascade facilitated by IQGAP1 regulates stable microtubules in migrating cells.
27006447	FASEB J.	2016	Black KE et al.	Autotaxin activity increases locally following lung injury, but is not required for pulmonary lysophosphatidic acid production or fibrosis.
26476080	Neoplasia	2015	Mukherjee A et al.	Lysophosphatidic Acid Up-Regulates Hexokinase II and Glycolysis to Promote Proliferation of Ovarian Cancer Cells.
26345369	J. Cell. Sci.	2015	Yukiura H et al.	LPP3 localizes LPA6 signalling to non-contact sites in endothelial cells.
26180199	J. Neurosci.	2015	Santos-Nogueira E et al.	Activation of Lysophosphatidic Acid Receptor Type 1 Contributes to Pathophysiology of Spinal Cord Injury.
26101324	J. Immunol.	2015	McArthur S et al.	Definition of a Novel Pathway Centered on Lysophosphatidic Acid To Recruit Monocytes during the Resolution Phase of Tissue Inflammation.
26041536	J. Immunol.	2015	Causton B et al.	CARMA3 Is Critical for the Initiation of Allergic Airway Inflammation.
25852197	Development	2015	Sheng X et al.	Lysophosphatidic acid signalling in development.
25695267	Neuron	2015	Yung YC et al.	Lysophosphatidic Acid signaling in the nervous system.
25555354	Prostaglandins Leukot. Essent. Fatty Acids	2015	Block RC et al.	The effects of aspirin on platelet function and lysophosphatidic acids depend on plasma concentrations of EPA and DHA.
25464168	Osteoarthr. Cartil.	2015	Wu L et al.	Lysophosphatidic acid mediates fibrosis in injured joints by regulating collagen type I biosynthesis.
25425621	Arterioscler. Thromb. Vasc. Biol.	2015	Kurano M et al.	Possible involvement of minor lysophospholipids in the increase in plasma lysophosphatidic acid in acute coronary syndrome.
25277122	Blood	2014	Leblanc R et al.	Interaction of platelet-derived autotaxin with tumor integrin αVβ3 controls metastasis of breast cancer cells to bone.
24530617	J. Struct. Biol.	2014	García-González V et al.	Key structural arrangements at the C-terminus domain of CETP suggest a potential mechanism for lipid-transfer activity.