Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
PMID | Journal | Published Date | Author | Title |
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8702792 | J. Biol. Chem. | 1996 | Chen Y et al. | Docosahexaenoic acid modulates the interactions of the interphotoreceptor retinoid-binding protein with 11-cis-retinal. |
9637532 | J. Immunol. | 1998 | Cadroy Y et al. | Arachidonic acid enhances the tissue factor expression of mononuclear cells by the cyclo-oxygenase-1 pathway: beneficial effect of n-3 fatty acids. |
10476811 | Invest. Ophthalmol. Vis. Sci. | 1999 | Chen H et al. | Synthesis and release of docosahexaenoic acid by the RPE cells of prcd-affected dogs. |
11133697 | Biol. Reprod. | 2001 | Sorbera LA et al. | Effects of polyunsaturated fatty acids and prostaglandins on oocyte maturation in a marine teleost, the European sea bass (Dicentrarchus labrax). |
11470750 | Carcinogenesis | 2001 | Chung BH et al. | Effects of docosahexaenoic acid and eicosapentaenoic acid on androgen-mediated cell growth and gene expression in LNCaP prostate cancer cells. |
10899039 | Am. J. Physiol. Heart Circ. Physiol. | 2000 | Xiao YF et al. | Coexpression with beta(1)-subunit modifies the kinetics and fatty acid block of hH1(alpha) Na(+) channels. |
10982541 | Circulation | 2000 | Mori TA et al. | Differential effects of eicosapentaenoic acid and docosahexaenoic acid on vascular reactivity of the forearm microcirculation in hyperlipidemic, overweight men. |
14583629 | J. Biol. Chem. | 2004 | Madani S et al. | Diacylglycerols containing Omega 3 and Omega 6 fatty acids bind to RasGRP and modulate MAP kinase activation. |
20732876 | J. Biol. Chem. | 2010 | Arnold C et al. | Arachidonic acid-metabolizing cytochrome P450 enzymes are targets of {omega}-3 fatty acids. |
21393477 | Carcinogenesis | 2011 | Grant GE et al. | Enhanced formation of 5-oxo-6,8,11,14-eicosatetraenoic acid by cancer cells in response to oxidative stress, docosahexaenoic acid and neutrophil-derived 5-hydroxy-6,8,11,14-eicosatetraenoic acid. |
21478260 | FASEB J. | 2011 | Hellmann J et al. | Resolvin D1 decreases adipose tissue macrophage accumulation and improves insulin sensitivity in obese-diabetic mice. |
20956612 | FASEB J. | 2011 | Recchiuti A et al. | MicroRNAs in resolution of acute inflammation: identification of novel resolvin D1-miRNA circuits. |
20930167 | Arterioscler. Thromb. Vasc. Biol. | 2010 | Chang CL et al. | n-3 Fatty acids decrease arterial low-density lipoprotein cholesterol delivery and lipoprotein lipase levels in insulin-resistant mice. |
21156816 | J. Pharmacol. Exp. Ther. | 2011 | Li X et al. | Docosahexanoic acid-induced coronary arterial dilation: actions of 17S-hydroxy docosahexanoic acid on K+ channel activity. |
19234220 | J. Immunol. | 2009 | Hassan IR and Gronert K | Acute changes in dietary omega-3 and omega-6 polyunsaturated fatty acids have a pronounced impact on survival following ischemic renal injury and formation of renoprotective docosahexaenoic acid-derived protectin D1. |
19050288 | J. Immunol. | 2008 | Kasuga K et al. | Rapid appearance of resolvin precursors in inflammatory exudates: novel mechanisms in resolution. |
19443724 | Invest. Ophthalmol. Vis. Sci. | 2009 | Tian H et al. | Resolvins E1 and D1 in choroid-retinal endothelial cells and leukocytes: biosynthesis and mechanisms of anti-inflammatory actions. |
19453514 | FEMS Microbiol. Lett. | 2009 | Orikasa Y et al. | pfaB products determine the molecular species produced in bacterial polyunsaturated fatty acid biosynthesis. |
19567784 | Mol. Cancer Res. | 2009 | Altenburg JD and Siddiqui RA | Omega-3 polyunsaturated fatty acids down-modulate CXCR4 expression and function in MDA-MB-231 breast cancer cells. |
19797232 | Invest. Ophthalmol. Vis. Sci. | 2010 | Abrahan CE et al. | Synthesis of sphingosine is essential for oxidative stress-induced apoptosis of photoreceptors. |
19890019 | FASEB J. | 2010 | Gleissman H et al. | Docosahexaenoic acid metabolome in neural tumors: identification of cytotoxic intermediates. |
20624993 | J. Pharmacol. Exp. Ther. | 2010 | Khairallah RJ et al. | Treatment with docosahexaenoic acid, but not eicosapentaenoic acid, delays Ca2+-induced mitochondria permeability transition in normal and hypertrophied myocardium. |
21813701 | J. Neurosci. | 2011 | Beck G et al. | Neuroaxonal dystrophy in calcium-independent phospholipase A2β deficiency results from insufficient remodeling and degeneration of mitochondrial and presynaptic membranes. |
17962433 | Invest. Ophthalmol. Vis. Sci. | 2007 | Bazan NG | Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture. |
17420205 | Antimicrob. Agents Chemother. | 2007 | Yano M et al. | Comprehensive analysis of the effects of ordinary nutrients on hepatitis C virus RNA replication in cell culture. |
18065628 | Appl. Environ. Microbiol. | 2008 | Okuyama H et al. | Significance of antioxidative functions of eicosapentaenoic and docosahexaenoic acids in marine microorganisms. |
17699343 | Clin J Am Soc Nephrol | 2006 | Hogg RJ et al. | Efficacy of omega-3 fatty acids in children and adults with IgA nephropathy is dosage- and size-dependent. |
16216871 | J. Biol. Chem. | 2005 | Ariel A et al. | The docosatriene protectin D1 is produced by TH2 skewing and promotes human T cell apoptosis via lipid raft clustering. |
16299163 | Drug Metab. Dispos. | 2006 | Hirunpanich V et al. | Demonstration of docosahexaenoic acid as a bioavailability enhancer for CYP3A substrates: in vitro and in vivo evidence using cyclosporin in rats. |
15655248 | J. Biol. Chem. | 2005 | Marszalek JR et al. | Long-chain acyl-CoA synthetase 6 preferentially promotes DHA metabolism. |
16565407 | Invest. Ophthalmol. Vis. Sci. | 2006 | German OL et al. | Ceramide is a mediator of apoptosis in retina photoreceptors. |
16424216 | J. Immunol. | 2006 | Serhan CN et al. | Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes. |
16467192 | Sci. STKE | 2006 | Gough NR | Focus issue: signaling lipids. |
17035384 | Cancer Epidemiol. Biomarkers Prev. | 2006 | Kuriki K et al. | Risk of colorectal cancer is linked to erythrocyte compositions of fatty acids as biomarkers for dietary intakes of fish, fat, and fatty acids. |
17052999 | Carcinogenesis | 2007 | Horia E and Watkins BA | Complementary actions of docosahexaenoic acid and genistein on COX-2, PGE2 and invasiveness in MDA-MB-231 breast cancer cells. |
17122401 | Appl. Environ. Microbiol. | 2007 | Okuyama H et al. | Bacterial genes responsible for the biosynthesis of eicosapentaenoic and docosahexaenoic acids and their heterologous expression. |
17056514 | J. Immunol. | 2006 | Duffield JS et al. | Resolvin D series and protectin D1 mitigate acute kidney injury. |
17056761 | FASEB J. | 2006 | González-Périz A et al. | Docosahexaenoic acid (DHA) blunts liver injury by conversion to protective lipid mediators: protectin D1 and 17S-hydroxy-DHA. |
17244615 | J. Biol. Chem. | 2007 | Sun YP et al. | Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation. |
22013115 | J. Immunol. | 2011 | Titos E et al. | Resolvin D1 and its precursor docosahexaenoic acid promote resolution of adipose tissue inflammation by eliciting macrophage polarization toward an M2-like phenotype. |
22332072 | Adv Nutr | 2011 | Kalupahana NS et al. | (n-3) Fatty acids alleviate adipose tissue inflammation and insulin resistance: mechanistic insights. |
22912397 | Clin. Chem. | 2012 | Mas E et al. | Resolvins D1, D2, and other mediators of self-limited resolution of inflammation in human blood following n-3 fatty acid supplementation. |
22904297 | Blood | 2012 | Dalli J and Serhan CN | Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators. |
21724996 | J. Immunol. | 2011 | Bento AF et al. | Omega-3 fatty acid-derived mediators 17(R)-hydroxy docosahexaenoic acid, aspirin-triggered resolvin D1 and resolvin D2 prevent experimental colitis in mice. |
22772592 | Mol. Pharmacol. | 2012 | Nakano M et al. | CYP4V2 in Bietti's crystalline dystrophy: ocular localization, metabolism of ω-3-polyunsaturated fatty acids, and functional deficit of the p.H331P variant. |
23103493 | Am. J. Physiol. Heart Circ. Physiol. | 2013 | Galvao TF et al. | Marine n3 polyunsaturated fatty acids enhance resistance to mitochondrial permeability transition in heart failure but do not improve survival. |
23174566 | Am. J. Physiol., Cell Physiol. | 2013 | Larson MK et al. | Exogenous modification of platelet membranes with the omega-3 fatty acids EPA and DHA reduces platelet procoagulant activity and thrombus formation. |
24228198 | Adv Nutr | 2013 | Cederholm T et al. | ω-3 fatty acids in the prevention of cognitive decline in humans. |