phosphatidylinositol-4-phosphate is a lipid of Glycerophospholipids (GP) class. Phosphatidylinositol-4-phosphate is associated with abnormalities such as Renal tubular disorder, Oculocerebrorenal Syndrome, Lowe, Infection and Rhinovirus infection. The involved functions are known as Agent, Signal Transduction, Synthesis, Regulation and Process. Phosphatidylinositol-4-phosphate often locates in Membrane, Tissue membrane, Endosomes, Cytoskeleton and Cell membrane. The associated genes with phosphatidylinositol-4-phosphate are Homologous Gene, Homologous Protein, CDC42 gene, Genome and PIK4CB gene. The related lipids are phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, Phosphatidylserines, phosphatidylinositol 3-phosphate and Total cholesterol.
PMID | Journal | Published Date | Author | Title |
---|---|---|---|---|
26972044 | Biochim. Biophys. Acta | 2016 | Yoshida A et al. | Nanoscale analysis reveals agonist-sensitive and heterogeneous pools of phosphatidylinositol 4-phosphate in the plasma membrane. |
26206936 | Science | 2015 | Moser von Filseck J et al. | INTRACELLULAR TRANSPORT. Phosphatidylserine transport by ORP/Osh proteins is driven by phosphatidylinositol 4-phosphate. |
26206935 | Science | 2015 | Chung J et al. | INTRACELLULAR TRANSPORT. PI4P/phosphatidylserine countertransport at ORP5- and ORP8-mediated ER-plasma membrane contacts. |
26124136 | Proc. Natl. Acad. Sci. U.S.A. | 2015 | Ghugtyal V et al. | Phosphatidylinositol-4-phosphate-dependent membrane traffic is critical for fungal filamentous growth. |
26038556 | Proc. Natl. Acad. Sci. U.S.A. | 2015 | Wang H et al. | GABARAPs regulate PI4P-dependent autophagosome:lysosome fusion. |
25825728 | Proc. Natl. Acad. Sci. U.S.A. | 2015 | Jeschke A et al. | Phosphatidylinositol 4-phosphate and phosphatidylinositol 3-phosphate regulate phagolysosome biogenesis. |
25736058 | Plant Cell | 2015 | Okazaki K et al. | Phosphatidylinositol 4-phosphate negatively regulates chloroplast division in Arabidopsis. |
25525797 | Cell Host Microbe | 2014 | Roulin PS et al. | Rhinovirus uses a phosphatidylinositol 4-phosphate/cholesterol counter-current for the formation of replication compartments at the ER-Golgi interface. |
25224012 | Antimicrob. Agents Chemother. | 2014 | Reghellin V et al. | NS5A inhibitors impair NS5A-phosphatidylinositol 4-kinase IIIα complex formation and cause a decrease of phosphatidylinositol 4-phosphate and cholesterol levels in hepatitis C virus-associated membranes. |
25113029 | J. Cell Biol. | 2014 | Cai Y et al. | Sac1-Vps74 structure reveals a mechanism to terminate phosphoinositide signaling in the Golgi apparatus. |
25024371 | Infect. Immun. | 2014 | Dolinsky S et al. | The Legionella longbeachae Icm/Dot substrate SidC selectively binds phosphatidylinositol 4-phosphate with nanomolar affinity and promotes pathogen vacuole-endoplasmic reticulum interactions. |
24706697 | Cancer Res. | 2014 | Tokuda E et al. | Phosphatidylinositol 4-phosphate in the Golgi apparatus regulates cell-cell adhesion and invasive cell migration in human breast cancer. |
24522181 | J. Cell. Sci. | 2014 | Klinkenberg D et al. | A cascade of ER exit site assembly that is regulated by p125A and lipid signals. |
23608234 | Prog. Lipid Res. | 2013 | Clayton EL et al. | Mammalian phosphatidylinositol 4-kinases as modulators of membrane trafficking and lipid signaling networks. |
22722250 | Science | 2012 | Hammond GR et al. | PI4P and PI(4,5)P2 are essential but independent lipid determinants of membrane identity. |
22538354 | Biochim. Biophys. Acta | 2012 | Boggs JM et al. | Effect of phosphorylation of phosphatidylinositol on myelin basic protein-mediated binding of actin filaments to lipid bilayers in vitro. |
21764313 | Trends Cell Biol. | 2011 | Santiago-Tirado FH and Bretscher A | Membrane-trafficking sorting hubs: cooperation between PI4P and small GTPases at the trans-Golgi network. |
19794145 | Am. J. Physiol., Cell Physiol. | 2009 | Yui N et al. | FAPP2 is required for aquaporin-2 apical sorting at trans-Golgi network in polarized MDCK cells. |
19596799 | J. Cell. Sci. | 2009 | Chan MW et al. | FAK, PIP5KIgamma and gelsolin cooperatively mediate force-induced expression of alpha-smooth muscle actin. |
19075114 | J. Cell Biol. | 2008 | Baird D et al. | Assembly of the PtdIns 4-kinase Stt4 complex at the plasma membrane requires Ypp1 and Efr3. |
16492770 | Proc. Natl. Acad. Sci. U.S.A. | 2006 | Baust T et al. | Proteomic analysis of adaptor protein 1A coats selectively assembled on liposomes. |
16103222 | J. Cell Biol. | 2005 | Vieira OV et al. | FAPP2 is involved in the transport of apical cargo in polarized MDCK cells. |
15657391 | J. Cell Biol. | 2005 | Faulhammer F et al. | Cell growth-dependent coordination of lipid signaling and glycosylation is mediated by interactions between Sac1p and Dpm1p. |
12914695 | Cell | 2003 | Wang YJ et al. | Phosphatidylinositol 4 phosphate regulates targeting of clathrin adaptor AP-1 complexes to the Golgi. |
10191310 | J. Neurosci. | 1999 | Zhainazarov AB and Ache BW | Effects of phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 4-phosphate on a Na+-gated nonselective cation channel. |
1311174 | Biochem. J. | 1992 | Roldan ER and Harrison RA | The role of diacylglycerol in the exocytosis of the sperm acrosome. Studies using diacylglycerol lipase and diacylglycerol kinase inhibitors and exogenous diacylglycerols. |
2845924 | Biochem. J. | 1988 | Steen VM et al. | Synergism between thrombin and adrenaline (epinephrine) in human platelets. Marked potentiation of inositol phospholipid metabolism. |
2821996 | Biochem. J. | 1987 | Hegewald H et al. | Influence of Ca2+ and Mg2+ on the turnover of the phosphomonoester group of phosphatidylinositol 4-phosphate in human erythrocyte membranes. |
6331389 | Biochem. J. | 1984 | Tooke NE et al. | Ca2+-sensitive phosphatidylinositol 4-phosphate metabolism in a rat beta-cell tumour. |