MAYTANSINE
MAYTANSINE is a lipid of Polyketides (PK) class. Maytansine is associated with abnormalities such as Myelosuppression and BOSLEY-SALIH-ALORAINY SYNDROME. The involved functions are known as Mutation, Agent, Polymerization, Cell Cycle Arrest and Drug Kinetics. Maytansine often locates in Cytoplasm, Hepatic, Lysosomes, Cell surface and Microtubules. The associated genes with MAYTANSINE are ABCB1 gene, HM13 gene, CNN1 gene, CYP2C8 gene and CYP2D6 gene. The related lipids are Valerates. The related experimental models are Xenograft Model.
References related to locations published in Others
| PMID | Journal | Published Date | Author | Title |
|---|---|---|---|---|
| 14634038 | J. Pharmacol. Exp. Ther. | 2004 | Xie H et al. | Pharmacokinetics and biodistribution of the antitumor immunoconjugate, cantuzumab mertansine (huC242-DM1), and its two components in mice. |
| 20937594 | Mol. Cancer Ther. | 2010 | Lopus M et al. | Maytansine and cellular metabolites of antibody-maytansinoid conjugates strongly suppress microtubule dynamics by binding to microtubules. |
| 20937595 | Mol. Cancer Ther. | 2010 | Oroudjev E et al. | Maytansinoid-antibody conjugates induce mitotic arrest by suppressing microtubule dynamic instability. |
| 22752008 | Drug Metab. Dispos. | 2012 | Davis JA et al. | In vitro characterization of the drug-drug interaction potential of catabolites of antibody-maytansinoid conjugates. |
| 25114240 | Proc. Natl. Acad. Sci. U.S.A. | 2014 | Prota AE et al. | A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs. |