Epothilone B

Epothilone B is a lipid of Polyketides (PK) class. Epothilone b is associated with abnormalities such as Myelosuppression, Measurable Disease, Neuropathy, Neutropenia and Thrombocytopenia. The involved functions are known as Cell Cycle Arrest, Apoptosis, Signal Transduction, Cytokinesis and Caspase Activation. Epothilone b often locates in Mitochondria, Cytoplasmic matrix, Microtubules, Spindle and Protoplasm. The associated genes with Epothilone B are TNFSF10 gene, DIABLO gene, FADD gene, BCL2 gene and BCL2L1 gene. The related lipids are Promega and Phosphatidylserines. The related experimental models are Xenograft Model and Mouse Model.

References related to locations published in Others

PMID	Journal	Published Date	Author	Title
11964312	Blood	2002	Guo F et al.	Ectopic overexpression of second mitochondria-derived activator of caspases (Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide potentiates epothilone B derivative-(BMS 247550) and Apo-2L/TRAIL-induced apoptosis.
15367426	Blood	2005	Lin B et al.	Patupilone (epothilone B) inhibits growth and survival of multiple myeloma cells in vitro and in vivo.
21245138	J. Biol. Chem.	2011	Khrapunovich-Baine M et al.	Hallmarks of molecular action of microtubule stabilizing agents: effects of epothilone B, ixabepilone, peloruside A, and laulimalide on microtubule conformation.
19087985	Ann. Oncol.	2009	Hussain A et al.	Phase II trial of weekly patupilone in patients with castration-resistant prostate cancer.
21743064	Neuro-oncology	2011	Oehler C et al.	The microtubule stabilizer patupilone (epothilone B) is a potent radiosensitizer in medulloblastoma cells.
17289837	J. Pharmacol. Exp. Ther.	2007	Lim Y et al.	Epothilone B inhibits neointimal formation after rat carotid injury through the regulation of cell cycle-related proteins.
16301595	J. Clin. Oncol.	2005	Rubin EH et al.	Phase I dose-finding study of weekly single-agent patupilone in patients with advanced solid tumors.
18593821	Mol. Pharmacol.	2008	Khawaja NR et al.	Patupilone-induced apoptosis is mediated by mitochondrial reactive oxygen species through Bim relocalization to mitochondria.
21953449	J. Biol. Chem.	2011	Lin PC et al.	Collapsin response mediator proteins (CRMPs) are a new class of microtubule-associated protein (MAP) that selectively interacts with assembled microtubules via a taxol-sensitive binding interaction.
22987083	J. Clin. Oncol.	2012	Colombo N et al.	Randomized, open-label, phase III study comparing patupilone (EPO906) with pegylated liposomal doxorubicin in platinum-refractory or -resistant patients with recurrent epithelial ovarian, primary fallopian tube, or primary peritoneal cancer.
26883566	Exp. Neurol.	2016	Pittman SK et al.	Nerve growth factor alters microtubule targeting agent-induced neurotransmitter release but not MTA-induced neurite retraction in sensory neurons.
25765066	Science	2015	Ruschel J et al.	Axonal regeneration. Systemic administration of epothilone B promotes axon regeneration after spinal cord injury.