rotenone

rotenone is a lipid of Polyketides (PK) class. Rotenone is associated with abnormalities such as Parkinson Disease, MYOPATHY, DISTAL, WITH ANTERIOR TIBIAL ONSET, Neurodegenerative Disorders, Septicemia and Respiratory Failure. The involved functions are known as Phosphorylation, Process, Cell Death, proteasome activity and Apoptosis. Rotenone often locates in Protoplasm, Presynaptic Terminals, Neurites, NADH dehydrogenase complex and Mitochondria. The associated genes with rotenone are DNAJB9 gene, EIF2S3 gene, Candidate Disease Gene, G-substrate and ERN1 gene. The related lipids are Lipopolysaccharides, Membrane Lipids, Phosphatidylserines, Fatty Acids and Cardiolipins. The related experimental models are Knock-out, Mouse Model, Disease model and Rodent Model.

References related to locations published in Others

PMID	Journal	Published Date	Author	Title
9707444	EMBO J.	1998	Bai Y and Attardi G	The mtDNA-encoded ND6 subunit of mitochondrial NADH dehydrogenase is essential for the assembly of the membrane arm and the respiratory function of the enzyme.
11216526	J. Nucl. Med.	2001	Marshall RC et al.	Kinetic analysis of 125I-iodorotenone as a deposited myocardial flow tracer: comparison with 99mTc-sestamibi.
11566731	Biol. Reprod.	2001	Vernet P et al.	Analysis of reactive oxygen species generating systems in rat epididymal spermatozoa.
12151355	Carcinogenesis	2002	Tanaka T et al.	Modifying effects of dietary capsaicin and rotenone on 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis.
12110535	Am. J. Physiol. Endocrinol. Metab.	2002	MacDonald MJ	Differences between mouse and rat pancreatic islets: succinate responsiveness, malic enzyme, and anaplerosis.
11961005	J. Am. Soc. Nephrol.	2002	Morigi M et al.	Protein overload-induced NF-kappaB activation in proximal tubular cells requires H(2)O(2) through a PKC-dependent pathway.
11964372	Circ. Res.	2002	Swärd K et al.	Influence of mitochondrial inhibition on global and local [Ca(2+)](I) in rat tail artery.
12958040	Arterioscler. Thromb. Vasc. Biol.	2003	Cowan DB et al.	Hypoxia and stretch regulate intercellular communication in vascular smooth muscle cells through reactive oxygen species formation.
12591974	J. Natl. Cancer Inst.	2003	Crowell JA and Steele VE	AKT and the phosphatidylinositol 3-kinase/AKT pathway: important molecular targets for lung cancer prevention and treatment.
12468742	Plant Cell	2002	Karpova OV et al.	Differential expression of alternative oxidase genes in maize mitochondrial mutants.
11046005	J. Immunol.	2000	Torres-Roca JF et al.	An early oxygen-dependent step is required for dexamethasone-induced apoptosis of immature mouse thymocytes.
11076830	Circulation	2000	Hu Q and Ziegelstein RC	Hypoxia/reoxygenation stimulates intracellular calcium oscillations in human aortic endothelial cells.
11080300	Plant Physiol.	2000	Sabar M et al.	Complex I impairment, respiratory compensations, and photosynthetic decrease in nuclear and mitochondrial male sterile mutants of Nicotiana sylvestris.
10904037	J. Appl. Physiol.	2000	Nethery D et al.	PLA(2) dependence of diaphragm mitochondrial formation of reactive oxygen species.
10696782	Toxicol. Sci.	2000	Isenberg JS and Klaunig JE	Role of the mitochondrial membrane permeability transition (MPT) in rotenone-induced apoptosis in liver cells.
9804614	Mol. Pharmacol.	1998	Leist M et al.	1-Methyl-4-phenylpyridinium induces autocrine excitotoxicity, protease activation, and neuronal apoptosis.
14665431	Am. J. Physiol. Renal Physiol.	2004	Feldkamp T et al.	Preservation of complex I function during hypoxia-reoxygenation-induced mitochondrial injury in proximal tubules.
14638429	FEMS Microbiol. Lett.	2003	Palese LL et al.	Characterization of plasma membrane respiratory chain and ATPase in the actinomycete Nonomuraea sp. ATCC 39727.
14555771	Plant Physiol.	2003	Millar AH et al.	Control of ascorbate synthesis by respiration and its implications for stress responses.
15319488	Toxicol. Sci.	2004	Sanderson JT et al.	Induction and inhibition of aromatase (CYP19) activity by natural and synthetic flavonoid compounds in H295R human adrenocortical carcinoma cells.
15268949	FEMS Microbiol. Lett.	2004	Chen Y and Suzuki I	Effect of uncouplers on endogenous respiration and ferrous iron oxidation in a chemolithoautotrophic bacterium Acidithiobacillus (Thiobacillus) ferrooxidans.
14962977	Hum. Mol. Genet.	2004	Ruan Q et al.	Striatal cells from mutant huntingtin knock-in mice are selectively vulnerable to mitochondrial complex II inhibitor-induced cell death through a non-apoptotic pathway.
14699012	Circ. Res.	2004	Cherednichenko G et al.	NADH oxidase activity of rat cardiac sarcoplasmic reticulum regulates calcium-induced calcium release.
14676274	J. Cell. Sci.	2004	Baker MA et al.	Analysis of the mechanism by which calcium negatively regulates the tyrosine phosphorylation cascade associated with sperm capacitation.
20713914	Hypertension	2010	Shahid M et al.	Impaired 3',5'-cyclic adenosine monophosphate-mediated signaling in immediate early responsive gene X-1-deficient vascular smooth muscle cells.
21300668	Hypertension	2011	Rowlands DJ et al.	Equol-stimulated mitochondrial reactive oxygen species activate endothelial nitric oxide synthase and redox signaling in endothelial cells: roles for F-actin and GPR30.
21212096	J. Endocrinol.	2011	Caton PW et al.	Fructose induces gluconeogenesis and lipogenesis through a SIRT1-dependent mechanism.
19297545	Am. J. Physiol. Regul. Integr. Comp. Physiol.	2009	Pilarski JQ et al.	Effects of aerobic and anaerobic metabolic inhibitors on avian intrapulmonary chemoreceptors.
18957561	Clin. Chem.	2008	de Wit LE et al.	Correct assay of complex I activity in human skin fibroblasts by timely addition of rotenone.
20360439	J. Appl. Physiol.	2010	Zerpa H et al.	Rho kinase activation and ROS production contributes to the cooling enhanced contraction in cutaneous equine digital veins.
20038714	Dis Model Mech	2010 Mar-Apr	Su LJ et al.	Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models.
22072507	J. Neurophysiol.	2012	Tu H et al.	Mitochondria-derived superoxide and voltage-gated sodium channels in baroreceptor neurons from chronic heart-failure rats.
17967937	J. Pharmacol. Exp. Ther.	2008	Kim JH et al.	Antiangiogenic effect of deguelin on choroidal neovascularization.
17596522	Am. J. Physiol. Renal Physiol.	2007	Zhang A et al.	Aldosterone induces epithelial-mesenchymal transition via ROS of mitochondrial origin.
17438209	Biol. Bull.	2007	Tong JJ	Mitochondrial delivery is essential for synaptic potentiation.
17428841	Am. J. Physiol., Cell Physiol.	2007	Koopman WJ et al.	Human NADH:ubiquinone oxidoreductase deficiency: radical changes in mitochondrial morphology?
17324951	Toxicol. Sci.	2007	Klintworth H et al.	Activation of c-Jun N-terminal protein kinase is a common mechanism underlying paraquat- and rotenone-induced dopaminergic cell apoptosis.
18032788	J. Cell. Sci.	2007	Chen Y et al.	Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species.
17726156	J. Pharmacol. Exp. Ther.	2007	Watabe M and Nakaki T	Mitochondrial complex I inhibitor rotenone-elicited dopamine redistribution from vesicles to cytosol in human dopaminergic SH-SY5Y cells.
18375872	J. Gerontol. A Biol. Sci. Med. Sci.	2008	Salmon AB et al.	Fibroblasts from naked mole-rats are resistant to multiple forms of cell injury, but sensitive to peroxide, ultraviolet light, and endoplasmic reticulum stress.
15764673	Am. J. Physiol. Heart Circ. Physiol.	2005	Bailey SR et al.	Reactive oxygen species from smooth muscle mitochondria initiate cold-induced constriction of cutaneous arteries.
15647387	Am. J. Physiol., Cell Physiol.	2005	Koopman WJ et al.	Inhibition of complex I of the electron transport chain causes O2-. -mediated mitochondrial outgrowth.
14976342	Toxicol. Sci.	2004	Newhouse K et al.	Rotenone-induced apoptosis is mediated by p38 and JNK MAP kinases in human dopaminergic SH-SY5Y cells.
15047621	Diabetes	2004	Brunmair B et al.	Thiazolidinediones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions?
16288111	J. Natl. Cancer Inst.	2005	Hecht SS	Deguelin as a chemopreventive agent in mouse lung tumorigenesis induced by tobacco smoke carcinogens.
15671057	Mutagenesis	2005	Harvey JS et al.	The results of five coded compounds: genistein, metaproterenol, rotenone, p-anisidine and resorcinol tested in the pH 6.7 Syrian hamster embryo cell morphological transformation assay.
15913578	Cardiovasc. Res.	2005	Sato H et al.	Mitochondrial reactive oxygen species and c-Src play a critical role in hypoxic response in vascular smooth muscle cells.
16972982	FEMS Yeast Res.	2006	Liu L et al.	Significant increase of glycolytic flux in Torulopsis glabrata by inhibition of oxidative phosphorylation.
16854843	Mol. Cell Proteomics	2007	Jin J et al.	Identification of novel proteins associated with both alpha-synuclein and DJ-1.
16565515	Mol. Cell Proteomics	2006	Jin J et al.	Proteomic identification of a stress protein, mortalin/mthsp70/GRP75: relevance to Parkinson disease.
16952909	Carcinogenesis	2007	Dell'Eva R et al.	The Akt inhibitor deguelin, is an angiopreventive agent also acting on the NF-kappaB pathway.
16804079	Diabetes	2006	Leloup C et al.	Mitochondrial reactive oxygen species are required for hypothalamic glucose sensing.
16207793	Am. J. Physiol., Cell Physiol.	2006	Potokar M et al.	Subcellular localization of Apaf-1 in apoptotic rat pituitary cells.
17208207	Cardiovasc. Res.	2007	Cancherini DV et al.	Pharmacological and physiological stimuli do not promote Ca(2+)-sensitive K+ channel activity in isolated heart mitochondria.
18480073	Toxicol. Sci.	2008	Sanchez M et al.	Rotenone-induced toxicity is mediated by Rho-GTPases in hippocampal neurons.
18599602	Mol. Pharmacol.	2008	Watabe M and Nakaki T	Mitochondrial complex I inhibitor rotenone inhibits and redistributes vesicular monoamine transporter 2 via nitration in human dopaminergic SH-SY5Y cells.
18784283	Plant Physiol.	2008	Garmier M et al.	Complex I dysfunction redirects cellular and mitochondrial metabolism in Arabidopsis.
21975873	Am. J. Physiol. Renal Physiol.	2012	Ohsaki Y et al.	Increase of sodium delivery stimulates the mitochondrial respiratory chain H2O2 production in rat renal medullary thick ascending limb.
22229125	Cold Spring Harb Perspect Med	2011	Tieu K	A guide to neurotoxic animal models of Parkinson's disease.
23788766	Arterioscler. Thromb. Vasc. Biol.	2013	Pung YF et al.	Mitochondrial oxidative stress corrupts coronary collateral growth by activating adenosine monophosphate activated kinase-α signaling.
23535362	Toxicol. Sci.	2013	Chorfa A et al.	Specific pesticide-dependent increases in α-synuclein levels in human neuroblastoma (SH-SY5Y) and melanoma (SK-MEL-2) cell lines.
23997112	Toxicol. Sci.	2013	Garcia-Garcia A et al.	Impairment of Atg5-dependent autophagic flux promotes paraquat- and MPP⁺-induced apoptosis but not rotenone or 6-hydroxydopamine toxicity.
18235013	Invest. Ophthalmol. Vis. Sci.	2008	Ghelli A et al.	Protection against oxidant-induced apoptosis by exogenous glutathione in Leber hereditary optic neuropathy cybrids.
26358042	FASEB J.	2016	Németh B et al.	Abolition of mitochondrial substrate-level phosphorylation by itaconic acid produced by LPS-induced Irg1 expression in cells of murine macrophage lineage.
26031332	Mol. Cell. Biol.	2015	Hou YS et al.	Sestrin2 Protects Dopaminergic Cells against Rotenone Toxicity through AMPK-Dependent Autophagy Activation.
25496994	Toxicology	2015	Choi WS et al.	JNK inhibition of VMAT2 contributes to rotenone-induced oxidative stress and dopamine neuron death.
24792327	Neurotoxicology	2014	Rojas-Charry L et al.	Downregulation of Pink1 influences mitochondrial fusion-fission machinery and sensitizes to neurotoxins in dopaminergic cells.
23899557	Cell. Signal.	2013	Green ML et al.	Release of targeted p53 from the mitochondrion as an early signal during mitochondrial dysfunction.
27413198	Am. J. Physiol. Renal Physiol.	2016	Sun Y et al.	Inhibition of mitochondrial complex-1 restores the downregulation of aquaporins in obstructive nephropathy.
26873970	Am. J. Physiol. Heart Circ. Physiol.	2016	Ochi R et al.	Rotenone-stimulated superoxide release from mitochondrial complex I acutely augments L-type Ca2+ current in A7r5 aortic smooth muscle cells.
26320949	Curr. Biol.	2015	Pacelli C et al.	Elevated Mitochondrial Bioenergetics and Axonal Arborization Size Are Key Contributors to the Vulnerability of Dopamine Neurons.
26141374	Brain Res.	2015	Hawong HY et al.	Comparison of the structure, function and autophagic maintenance of mitochondria in nigrostriatal and tuberoinfundibular dopamine neurons.
25862939	Neurobiol. Dis.	2015	Slone SR et al.	Increased 14-3-3 phosphorylation observed in Parkinson's disease reduces neuroprotective potential of 14-3-3 proteins.
25827955	Biochim. Biophys. Acta	2015	Grefte S et al.	Rotenone inhibits primary murine myotube formation via Raf-1 and ROCK2.
25481764	Neurosci. Lett.	2015	Zhang L et al.	Long-term evaluation of Leber's hereditary optic neuropathy-like symptoms in rotenone administered rats.
25155595	Antimicrob. Agents Chemother.	2014	Mesa-Arango AC et al.	The production of reactive oxygen species is a universal action mechanism of Amphotericin B against pathogenic yeasts and contributes to the fungicidal effect of this drug.
25063855	J. Exp. Biol.	2014	Dukoff DJ et al.	Scavenging ROS dramatically increase NMDA receptor whole-cell currents in painted turtle cortical neurons.
24965893	Neurobiol. Dis.	2014	Hwang RD et al.	The neuroprotective effect of human uncoupling protein 2 (hUCP2) requires cAMP-dependent protein kinase in a toxin model of Parkinson's disease.
24599491	Plant Physiol.	2014	Mor A et al.	Singlet oxygen signatures are detected independent of light or chloroplasts in response to multiple stresses.
24045019	Plant Cell	2013	De Clercq I et al.	The membrane-bound NAC transcription factor ANAC013 functions in mitochondrial retrograde regulation of the oxidative stress response in Arabidopsis.