apigenin

apigenin is a lipid of Polyketides (PK) class. Apigenin is associated with abnormalities such as Morphologically altered structure, Chimera disorder, Hypertensive disease, infection induced and Infection. The involved functions are known as inhibitors, Gene Expression, Process, Metabolic Inhibition and Cell Death. Apigenin often locates in Vacuole, Cytoplasmic matrix, Cytoplasm, Tissue membrane and Membrane. The associated genes with apigenin are MSMP gene, BCL2 gene, PTGS2 gene, Chromatin and SLC33A1 gene. The related lipids are Lipopolysaccharides, Steroids, 1-Butanol, agosterol A and Butyrates. The related experimental models are Mouse Model, Tissue Model, Knock-out, Xenograft Model and Disease model.

References related to locations published in Others

PMID	Journal	Published Date	Author	Title
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18178667	Mol. Pharmacol.	2008	Puppala D et al.	Development of an aryl hydrocarbon receptor antagonist using the proteolysis-targeting chimeric molecules approach: a potential tool for chemoprevention.
18413777	Cancer Res.	2008	Abu-Yousif AO et al.	Enhancement of UVB-induced apoptosis by apigenin in human keratinocytes and organotypic keratinocyte cultures.
16246933	J. Dent. Res.	2005	Koo H et al.	Apigenin and tt-farnesol with fluoride effects on S. mutans biofilms and dental caries.
15897466	Proc. Natl. Acad. Sci. U.S.A.	2005	Yamada M et al.	Inhibition of protein kinase CK2 prevents the progression of glomerulonephritis.
15947208	Mol. Pharmacol.	2005	Liu LZ et al.	Apigenin inhibits expression of vascular endothelial growth factor and angiogenesis in human lung cancer cells: implication of chemoprevention of lung cancer.
16436708	Antimicrob. Agents Chemother.	2006	Koo H et al.	Influence of apigenin on gtf gene expression in Streptococcus mutans UA159.
17074806	Mol. Cell. Biol.	2007	Tong X et al.	Apigenin prevents UVB-induced cyclooxygenase 2 expression: coupled mRNA stabilization and translational inhibition.
16982614	J. Biol. Chem.	2006	Balasubramanian S et al.	Apigenin inhibition of involucrin gene expression is associated with a specific reduction in phosphorylation of protein kinase Cdelta Tyr311.
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16648565	Mol. Cancer Ther.	2006	Horinaka M et al.	The dietary flavonoid apigenin sensitizes malignant tumor cells to tumor necrosis factor-related apoptosis-inducing ligand.
16782805	Mol. Pharmacol.	2006	Yoon MS et al.	Apigenin inhibits immunostimulatory function of dendritic cells: Implication of immunotherapeutic adjuvant.
18645020	Mol. Cancer Ther.	2008	Long X et al.	Apigenin inhibits antiestrogen-resistant breast cancer cell growth through estrogen receptor-alpha-dependent and estrogen receptor-alpha-independent mechanisms.
23475986	Mol. Hum. Reprod.	2013	Lim R et al.	Dietary phytophenols curcumin, naringenin and apigenin reduce infection-induced inflammatory and contractile pathways in human placenta, foetal membranes and myometrium.
23697369	Proc. Natl. Acad. Sci. U.S.A.	2013	Arango D et al.	Molecular basis for the action of a dietary flavonoid revealed by the comprehensive identification of apigenin human targets.
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21467581	Plant Cell	2011	Zhao J et al.	MATE2 mediates vacuolar sequestration of flavonoid glycosides and glycoside malonates in Medicago truncatula.
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25058688	Chem. Biol. Interact.	2014	Isoda H et al.	Analysis of the erythroid differentiation effect of flavonoid apigenin on K562 human chronic leukemia cells.
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26500281	Biosci. Rep.	2015	Seo HS et al.	Induction of caspase-dependent extrinsic apoptosis by apigenin through inhibition of signal transducer and activator of transcription 3 (STAT3) signalling in HER2-overexpressing BT-474 breast cancer cells.
26475103	Appl. Environ. Microbiol.	2015	Xia F et al.	Combination Therapy of LysGH15 and Apigenin as a New Strategy for Treating Pneumonia Caused by Staphylococcus aureus.
25965143	Redox Biol	2015	Banerjee K and Mandal M	Oxidative stress triggered by naturally occurring flavone apigenin results in senescence and chemotherapeutic effect in human colorectal cancer cells.