FLAVONE

FLAVONE is a lipid of Polyketides (PK) class. Flavone is associated with abnormalities such as Cardiovascular Diseases, Cerebrovascular accident, DERMATITIS HERPETIFORMIS, FAMILIAL, Hyperinsulinism and Inflammatory disorder. The involved functions are known as Oxidation-Reduction, Metabolic Inhibition, Inflammation, Phosphorylation and antioxidant activity. Flavone often locates in Endothelium, Hepatic, Protoplasm, Body tissue and Extracellular. The associated genes with FLAVONE are ICAM1 gene, BCL2L1 gene, MYC gene, TP53 gene and cytochrome c''. The related lipids are Promega, Steroids and Total cholesterol. The related experimental models are Knock-out, Disease model and Animal Disease Models.

References related to locations published in Others

PMID	Journal	Published Date	Author	Title
10919656	Cancer Res.	2000	Wenzel U et al.	Dietary flavone is a potent apoptosis inducer in human colon carcinoma cells.
16987811	J. Biol. Chem.	2006	Lotito SB and Frei B	Dietary flavonoids attenuate tumor necrosis factor alpha-induced adhesion molecule expression in human aortic endothelial cells. Structure-function relationships and activity after first pass metabolism.
22587837	Biochim. Biophys. Acta	2012	Hirohata M et al.	Anti-amyloidogenic effects of soybean isoflavones in vitro: Fluorescence spectroscopy demonstrating direct binding to Aβ monomers, oligomers and fibrils.
19074529	Drug Metab. Dispos.	2009	Si D et al.	Mechanism of CYP2C9 inhibition by flavones and flavonols.
23782265	Biochem. J.	2013	Wiejak J et al.	Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular endothelial cells.
25498791	J. Allergy Clin. Immunol.	2015	Weng Z et al.	The novel flavone tetramethoxyluteolin is a potent inhibitor of human mast cells.
21652696	J. Biol. Chem.	2011	Guo AJ et al.	Baicalin, a flavone, induces the differentiation of cultured osteoblasts: an action via the Wnt/beta-catenin signaling pathway.
21075839	J. Pharmacol. Exp. Ther.	2011	Wootten D et al.	Modulation of the glucagon-like peptide-1 receptor signaling by naturally occurring and synthetic flavonoids.
17418982	Cancer Detect. Prev.	2007	Ullmannova V and Popescu NC	Inhibition of cell proliferation, induction of apoptosis, reactivation of DLC1, and modulation of other gene expression by dietary flavone in breast cancer cell lines.
15661162	Virology	2005	Madan V et al.	Requirement of the vesicular system for membrane permeabilization by Sindbis virus.
14645680	Mol. Pharmacol.	2003	Wenzel U et al.	Nitric oxide levels in human preneoplastic colonocytes determine their susceptibility toward antineoplastic agents.
12644593	Mol. Pharmacol.	2003	Zhou JG et al.	Species-specific transcriptional activity of synthetic flavonoids in guinea pig and mouse cells as a result of differential activation of the aryl hydrocarbon receptor to interact with dioxin-responsive elements.