rottlerin

Rottlerin is a lipid of Polyketides (PK) class. Rottlerin is associated with abnormalities such as PARAGANGLIOMAS 2, Hyperostosis, Diffuse Idiopathic Skeletal, Virus Diseases, Perisylvian syndrome and Autoimmune disease (systemic) NOS. The involved functions are known as Apoptosis, Regulation, Signal Transduction, inhibitors and Proteasome Inhibitors [MoA]. Rottlerin often locates in Clone, Membrane, Body tissue, Plasma membrane and soluble. The associated genes with Rottlerin are XIAP gene, GAPDH gene, ICAM1 gene, P4HTM gene and TNFSF10 gene. The related lipids are Promega, Fatty Acids, Sphingolipids, Lipopolysaccharides and Saponin. The related experimental models are Mouse Model, Xenograft Model and Cancer Model.

References related to locations published in Others

PMID	Journal	Published Date	Author	Title
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12388079	Am. J. Physiol., Cell Physiol.	2003	Liedtke CM et al.	Stability of actin cytoskeleton and PKC-delta binding to actin regulate NKCC1 function in airway epithelial cells.
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12941843	Cancer Res.	2003	Tillman DM et al.	Rottlerin sensitizes colon carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via uncoupling of the mitochondria independent of protein kinase C.
12972622	Mol. Cell. Biol.	2003	Trushin SA et al.	Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
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19037087	Carcinogenesis	2009	Lim JH et al.	Rottlerin induces apoptosis via death receptor 5 (DR5) upregulation through CHOP-dependent and PKC delta-independent mechanism in human malignant tumor cells.
19420016	Carcinogenesis	2009	Park SK et al.	Kalopanaxsaponin A inhibits PMA-induced invasion by reducing matrix metalloproteinase-9 via PI3K/Akt- and PKCdelta-mediated signaling in MCF-7 human breast cancer cells.
20395372	J. Am. Soc. Nephrol.	2010	Li X et al.	PKC-delta promotes renal tubular cell apoptosis associated with proteinuria.
15342779	Mol. Biol. Cell	2004	Lladó A et al.	Protein kinaseCdelta-calmodulin crosstalk regulates epidermal growth factor receptor exit from early endosomes.
21911819	Circulation	2011	Clements RT et al.	Rottlerin increases cardiac contractile performance and coronary perfusion through BKCa++ channel activation after cold cardioplegic arrest in isolated hearts.
17901241	J. Appl. Physiol.	2007	Klinger JR et al.	Rottlerin causes pulmonary edema in vivo: a possible role for PKCdelta.
17404251	J. Immunol.	2007	Guo B et al.	Cutting Edge: B cell receptor (BCR) cross-talk: the IL-4-induced alternate pathway for BCR signaling operates in parallel with the classical pathway, is sensitive to Rottlerin, and depends on Lyn.
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18083882	Appl. Environ. Microbiol.	2008	Shivshankar P et al.	Rottlerin inhibits chlamydial intracellular growth and blocks chlamydial acquisition of sphingolipids from host cells.
18195168	Hypertension	2008	Olson ER et al.	Angiotensin II-induced extracellular signal-regulated kinase 1/2 activation is mediated by protein kinase Cdelta and intracellular calcium in adult rat cardiac fibroblasts.
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15917298	Mol. Biol. Cell	2005	Panaretakis T et al.	Doxorubicin requires the sequential activation of caspase-2, protein kinase Cdelta, and c-Jun NH2-terminal kinase to induce apoptosis.
15899849	Mol. Cell. Biol.	2005	Roose JP et al.	A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells.
16940418	Blood	2006	Pula G et al.	PKCdelta regulates collagen-induced platelet aggregation through inhibition of VASP-mediated filopodia formation.
16443207	Cardiovasc. Res.	2006	Zatta AJ et al.	Infarct-sparing effect of myocardial postconditioning is dependent on protein kinase C signalling.
17077164	J. Leukoc. Biol.	2007	Grybko MJ et al.	Protein kinase C activity is required for cytotoxic T cell lytic granule exocytosis, but the theta isoform does not play a preferential role.
17151144	Am. J. Physiol., Cell Physiol.	2007	Hassan HA et al.	Regulation of anion exchanger Slc26a6 by protein kinase C.
16614259	J. Leukoc. Biol.	2006	Cronshaw DG et al.	Evidence that phospholipase-C-dependent, calcium-independent mechanisms are required for directional migration of T-lymphocytes in response to the CCR4 ligands CCL17 and CCL22.
21990324	Endocr. Relat. Cancer	2011	Chen Z et al.	Protein kinase Cδ inactivation inhibits cellular proliferation and decreases survival in human neuroendocrine tumors.
23995289	FASEB J.	2013	Goldklang MP et al.	Treatment of experimental asthma using a single small molecule with anti-inflammatory and BK channel-activating properties.
24607787	Cell. Signal.	2014	Lu W et al.	Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.