cholesterol is a lipid of Sterol Lipids (ST) class. Cholesterol is associated with abnormalities such as Trypanosomiasis, Chagas Disease, Cleft Palate, Chondrodysplasia punctata 2, X-linked dominant and Child syndrome. The involved functions are known as Blood Circulation, Sterol Biosynthesis Pathway, Receptor Mediated Endocytosis, Methylation and Signal. Cholesterol often locates in Animal tissue, Blood, Membrane, Plasma membrane and peroxisome. The associated genes with cholesterol are MBD2 gene, SIM, SLC33A1 gene, Genome and NSDHL gene. The related lipids are Sterols, zymosterol, fecosterol, Total cholesterol and 7-dehydrocholesterol. The related experimental models are Mouse Model, Knock-out, Genetically Engineered Mouse and Disease model.
PMID | Journal | Published Date | Author | Title |
---|---|---|---|---|
7796498 | Circulation | 1995 | Goode GK and Heagerty AM | In vitro responses of human peripheral small arteries in hypercholesterolemia and effects of therapy. |
9405354 | EMBO J. | 1997 | Gadbut AP et al. | Induction of the cholesterol metabolic pathway regulates the farnesylation of RAS in embryonic chick heart cells: a new role for ras in regulating the expression of muscarinic receptors and G proteins. |
9462209 | Gut | 1997 | Hakala K et al. | Impaired absorption of cholesterol and bile acids in patients with an ileoanal anastomosis. |
8942999 | Proc. Natl. Acad. Sci. U.S.A. | 1996 | Nohturfft A et al. | Recurrent G-to-A substitution in a single codon of SREBP cleavage-activating protein causes sterol resistance in three mutant Chinese hamster ovary cell lines. |
9152381 | J. Pharmacol. Exp. Ther. | 1997 | Amin D et al. | RPR 107393, a potent squalene synthase inhibitor and orally effective cholesterol-lowering agent: comparison with inhibitors of HMG-CoA reductase. |
9082032 | J. Nutr. | 1997 | Morita T et al. | Cholesterol-lowering effects of soybean, potato and rice proteins depend on their low methionine contents in rats fed a cholesterol-free purified diet. |
9103500 | J. Pharmacol. Exp. Ther. | 1997 | Bowling N et al. | Effects of prolonged ethinyl estradiol treatment on calcium channel binding and in vivo calcium-mediated hemodynamic responses in ovariectomized rats. |
9024163 | Circulation | 1997 | Deckert V et al. | Inhibitors of arterial relaxation among components of human oxidized low-density lipoproteins. Cholesterol derivatives oxidized in position 7 are potent inhibitors of endothelium-dependent relaxation. |
8990234 | Clin. Chem. | 1997 | Jira PE et al. | Pitfalls in measuring plasma cholesterol in the Smith-Lemli-Opitz syndrome. |
9579167 | Arch. Dis. Child. | 1998 | Clayton PT | Disorders of cholesterol biosynthesis. |
9808646 | J. Nutr. | 1998 | Trautwein EA et al. | Dietary inulin lowers plasma cholesterol and triacylglycerol and alters biliary bile acid profile in hamsters. |
9765531 | Plant Physiol. | 1998 | Schaller H et al. | Overexpression of an Arabidopsis cDNA encoding a sterol-C24(1)-methyltransferase in tobacco modifies the ratio of 24-methyl cholesterol to sitosterol and is associated with growth reduction. |
10393050 | Invest. Ophthalmol. Vis. Sci. | 1999 | Fliesler SJ et al. | Marked alteration of sterol metabolism and composition without compromising retinal development or function. |
10356090 | J. Nutr. | 1999 | Nakamura Y et al. | Fecal steroid excretion is increased in rats by oral administration of gymnemic acids contained in Gymnema sylvestre leaves. |
10357732 | Am. J. Clin. Nutr. | 1999 | Jones PJ et al. | Cholesterol-lowering efficacy of a sitostanol-containing phytosterol mixture with a prudent diet in hyperlipidemic men. |
9649606 | J. Nutr. | 1998 | Buhman KK et al. | Dietary psyllium increases fecal bile acid excretion, total steroid excretion and bile acid biosynthesis in rats. |
10070053 | Am. J. Physiol. | 1999 | Wang DQ et al. | Cholic acid aids absorption, biliary secretion, and phase transitions of cholesterol in murine cholelithogenesis. |
10075964 | Gut | 1999 | Lanzarotto F et al. | Effect of long term simvastatin administration as an adjunct to ursodeoxycholic acid: evidence for a synergistic effect on biliary bile acid composition but not on serum lipids in humans. |
10026334 | Gut | 1999 | Van Erpecum KJ and Van Berge-Henegouwen GP | Gallstones: an intestinal disease? |
10541563 | Mol. Hum. Reprod. | 1999 | Osheroff JE et al. | Regulation of human sperm capacitation by a cholesterol efflux-stimulated signal transduction pathway leading to protein kinase A-mediated up-regulation of protein tyrosine phosphorylation. |
10441095 | Circulation | 1999 | Eriksson M et al. | Stimulation of fecal steroid excretion after infusion of recombinant proapolipoprotein A-I. Potential reverse cholesterol transport in humans. |
10460211 | J. Nutr. | 1999 | Nagaoka S et al. | Soy protein peptic hydrolysate with bound phospholipids decreases micellar solubility and cholesterol absorption in rats and caco-2 cells. |
9950808 | Am. J. Physiol. | 1999 | Wang H et al. | Regulation of apolipoprotein secretion by biliary lipids in newborn swine intestinal epithelial cells. |
11171976 | Proc. Natl. Acad. Sci. U.S.A. | 2001 | DeBose-Boyd RA et al. | Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands. |
11257033 | Antimicrob. Agents Chemother. | 2001 | Ramaswamy M et al. | Amphotericin B lipid complex or amphotericin B multiple-dose administration to rabbits with elevated plasma cholesterol levels: pharmacokinetics in plasma and blood, plasma lipoprotein levels, distribution in tissues, and renal toxicities. |
11160853 | Mol. Pharmacol. | 2001 | Reszka AA et al. | Nitrogen-bisphosphonates block retinoblastoma phosphorylation and cell growth by inhibiting the cholesterol biosynthetic pathway in a keratinocyte model for esophageal irritation. |
11591613 | Circulation | 2001 | Wakatsuki A et al. | Effect of medroxyprogesterone acetate on endothelium-dependent vasodilation in postmenopausal women receiving estrogen. |
11717136 | Biol. Reprod. | 2001 | Baltsen M | Gonadotropin-induced accumulation of 4,4-dimethylsterols in mouse ovaries and its temporal relation to meiosis. |
11861784 | J. Pharmacol. Exp. Ther. | 2002 | Galbiati E et al. | Effects of 3-phenyl-4-[[4-[2-(1-piperidinyl)ethoxy]phenyl]methyl]- 2H-1-benzopyran-7-ol (CHF 4056), a novel nonsteroidal estrogen agonist/antagonist, on reproductive and nonreproductive tissue. |
11302972 | Gut | 2001 | Fracchia M et al. | Biliary lipid composition in cholesterol microlithiasis. |
11319189 | Circulation | 2001 | Merten M et al. | Cholesterol sulfate: a new adhesive molecule for platelets. |
11427463 | Clin. Chem. | 2001 | Zawydiwski R et al. | A novel test for the measurement of skin cholesterol. |
11408580 | Mol. Biol. Cell | 2001 | Matyash V et al. | Distribution and transport of cholesterol in Caenorhabditis elegans. |
11435511 | J. Nutr. | 2001 | Tammi A et al. | Dietary plant sterols alter the serum plant sterol concentration but not the cholesterol precursor sterol concentrations in young children (the STRIP Study). Special Turku Coronary Risk Factor Intervention Project. |
12153993 | FASEB J. | 2002 | Plat J and Mensink RP | Increased intestinal ABCA1 expression contributes to the decrease in cholesterol absorption after plant stanol consumption. |
12016126 | Am. J. Physiol. Gastrointest. Liver Physiol. | 2002 | Nissinen M et al. | Micellar distribution of cholesterol and phytosterols after duodenal plant stanol ester infusion. |
12006351 | Am. J. Physiol. Endocrinol. Metab. | 2002 | Lindenthal B et al. | Isotopomer spectral analysis of intermediates of cholesterol synthesis in human subjects and hepatic cells. |
11988537 | Science | 2002 | Urizar NL et al. | A natural product that lowers cholesterol as an antagonist ligand for FXR. |
12081816 | Am. J. Clin. Nutr. | 2002 | Matvienko OA et al. | A single daily dose of soybean phytosterols in ground beef decreases serum total cholesterol and LDL cholesterol in young, mildly hypercholesterolemic men. |
12036855 | Blood | 2002 | Nguyen DH and Taub D | Cholesterol is essential for macrophage inflammatory protein 1 beta binding and conformational integrity of CC chemokine receptor 5. |
12042424 | J. Nutr. | 2002 | Ewart HS et al. | Fish oil containing phytosterol esters alters blood lipid profiles and left ventricle generation of thromboxane a(2) in adult guinea pigs. |
12368466 | Proc. Natl. Acad. Sci. U.S.A. | 2002 | Radhakrishnan A and McConnell HM | Critical points in charged membranes containing cholesterol. |
12388173 | Am. J. Physiol. Endocrinol. Metab. | 2002 | Sattler FR et al. | Metabolic effects of nandrolone decanoate and resistance training in men with HIV. |
12427790 | Gut | 2002 | Sudhop T et al. | Comparison of the hepatic clearances of campesterol, sitosterol, and cholesterol in healthy subjects suggests that efflux transporters controlling intestinal sterol absorption also regulate biliary secretion. |
12215500 | Plant Cell | 2002 | Clouse SD | Arabidopsis mutants reveal multiple roles for sterols in plant development. |
12815072 | Genes Dev. | 2003 | Holt JA et al. | Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis. |
12826580 | Biol. Reprod. | 2003 | Thérien I and Manjunath P | Effect of progesterone on bovine sperm capacitation and acrosome reaction. |
12832362 | Hum. Reprod. | 2003 | Alexandersen P et al. | Lack of difference among progestins on the anti-atherogenic effect of ethinyl estradiol: a rabbit study. |
12824470 | Proc. Natl. Acad. Sci. U.S.A. | 2003 | Zheng YH et al. | Nef increases the synthesis of and transports cholesterol to lipid rafts and HIV-1 progeny virions. |
12668600 | Hum. Mol. Genet. | 2003 | Herman GE | Disorders of cholesterol biosynthesis: prototypic metabolic malformation syndromes. |
12576301 | Am. J. Physiol. Gastrointest. Liver Physiol. | 2003 | Chiang JY | Bile acid regulation of hepatic physiology: III. Bile acids and nuclear receptors. |
12529392 | Mol. Cell. Biol. | 2003 | Otte K et al. | Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol. |
12569201 | Proc. Natl. Acad. Sci. U.S.A. | 2003 | Dussault I et al. | Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance. |
12606419 | Biol. Reprod. | 2003 | Nimmo MR and Cross NL | Structural features of sterols required to inhibit human sperm capacitation. |
12606523 | Diabetes | 2003 | Watts GF et al. | Differential regulation of lipoprotein kinetics by atorvastatin and fenofibrate in subjects with the metabolic syndrome. |
12444248 | Proc. Natl. Acad. Sci. U.S.A. | 2002 | Yu L et al. | Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion. |
12446833 | Proc. Natl. Acad. Sci. U.S.A. | 2002 | Sehayek E et al. | Loci on chromosomes 14 and 2, distinct from ABCG5/ABCG8, regulate plasma plant sterol levels in a C57BL/6J x CASA/Rk intercross. |
12450893 | Am. J. Clin. Nutr. | 2002 | Vanstone CA et al. | Unesterified plant sterols and stanols lower LDL-cholesterol concentrations equivalently in hypercholesterolemic persons. |
12509506 | Proc. Natl. Acad. Sci. U.S.A. | 2003 | Goodwin B et al. | Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor. |
12475962 | Mol. Biol. Cell | 2002 | Eisenkolb M et al. | A specific structural requirement for ergosterol in long-chain fatty acid synthesis mutants important for maintaining raft domains in yeast. |
12936912 | Am. J. Physiol. Gastrointest. Liver Physiol. | 2004 | Xiao ZL et al. | Role of PGE2 on gallbladder muscle cytoprotection of guinea pigs. |
10653533 | Toxicol. Sci. | 2000 | Duguay AB et al. | Manganese-bilirubin effect on cholesterol accumulation in rat bile canalicular membranes. |
10783363 | Hum. Reprod. | 2000 | Parinaud J et al. | Enhancement of zona binding using 2-hydroxypropyl- beta-cyclodextrin. |
10799370 | Am. J. Clin. Nutr. | 2000 | Miettinen TA et al. | Serum, biliary, and fecal cholesterol and plant sterols in colectomized patients before and during consumption of stanol ester margarine. |
10759480 | Clin. Chem. | 2000 | Garde AH et al. | Seasonal and biological variation of blood concentrations of total cholesterol, dehydroepiandrosterone sulfate, hemoglobin A(1c), IgA, prolactin, and free testosterone in healthy women. |
10752932 | Invest. Ophthalmol. Vis. Sci. | 2000 | Inoue K et al. | Cholestanol induces apoptosis of corneal endothelial and lens epithelial cells. |
11115826 | Gut | 2001 | Gilat T et al. | Fatty acid bile acid conjugates (FABACs)--new molecules for the prevention of cholesterol crystallisation in bile. |
10993836 | Biol. Reprod. | 2000 | Cross NL | Sphingomyelin modulates capacitation of human sperm in vitro. |
10946069 | Cardiovasc. Res. | 2000 | Gray DF et al. | HMG CoA reductase inhibition reduces sarcolemmal Na(+)-K(+) pump density. |
10888668 | Mol. Biol. Cell | 2000 | Chan JR et al. | Progesterone synthesized by Schwann cells during myelin formation regulates neuronal gene expression. |
10736328 | J. Nutr. | 2000 | Hallikainen MA et al. | Plant stanol esters affect serum cholesterol concentrations of hypercholesterolemic men and women in a dose-dependent manner. |
10731496 | Am. J. Clin. Nutr. | 2000 | Normén L et al. | Soy sterol esters and beta-sitostanol ester as inhibitors of cholesterol absorption in human small bowel. |
9761794 | Plant Cell | 1998 | Klahre U et al. | The Arabidopsis DIMINUTO/DWARF1 gene encodes a protein involved in steroid synthesis. |
9616123 | Science | 1998 | Cooper MK et al. | Teratogen-mediated inhibition of target tissue response to Shh signaling. |
9655903 | J. Pharmacol. Exp. Ther. | 1998 | Liu D and Bachmann KA | An investigation of the relationship between estrogen, estrogen metabolites and blood cholesterol levels in ovariectomized rats. |
10069828 | Plant Physiol. | 1999 | Choe S et al. | The Arabidopsis dwarf1 mutant is defective in the conversion of 24-methylenecholesterol to campesterol in brassinosteroid biosynthesis. |
11451730 | Am. J. Clin. Nutr. | 2001 | Normén AL et al. | Plant sterol intakes and colorectal cancer risk in the Netherlands Cohort Study on Diet and Cancer. |
11788421 | Am. J. Physiol. Heart Circ. Physiol. | 2002 | Brämswig S et al. | Carbamazepine increases atherogenic lipoproteins: mechanism of action in male adults. |
12379782 | J. Exp. Bot. | 2002 | Quartacci MF et al. | Plasma membrane lipids in the resurrection plant Ramonda serbica following dehydration and rehydration. |
14657168 | J. Neurosci. | 2003 | Zacco A et al. | 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors protect cortical neurons from excitotoxicity. |
14657394 | Proc. Natl. Acad. Sci. U.S.A. | 2003 | Guryev O et al. | A pathway for the metabolism of vitamin D3: unique hydroxylated metabolites formed during catalysis with cytochrome P450scc (CYP11A1). |
14652381 | J. Nutr. | 2003 | Muti P et al. | A plant food-based diet modifies the serum beta-sitosterol concentration in hyperandrogenic postmenopausal women. |
15310903 | Science | 2004 | Kawakubo M et al. | Natural antibiotic function of a human gastric mucin against Helicobacter pylori infection. |
15314240 | Proc. Natl. Acad. Sci. U.S.A. | 2004 | Ohgami N et al. | Binding between the Niemann-Pick C1 protein and a photoactivatable cholesterol analog requires a functional sterol-sensing domain. |
15247383 | Plant Physiol. | 2004 | Kim TW et al. | Novel biosynthetic pathway of castasterone from cholesterol in tomato. |
15269103 | Biol. Reprod. | 2004 | Cao X et al. | Meiosis-activating sterol synthesis in rat preovulatory follicle: is it involved in resumption of meiosis? |
15226455 | J. Nutr. | 2004 | Tomoyori H et al. | Phytosterol oxidation products are absorbed in the intestinal lymphatics in rats but do not accelerate atherosclerosis in apolipoprotein E-deficient mice. |
15155420 | Br J Sports Med | 2004 | Hartgens F et al. | Effects of androgenic-anabolic steroids on apolipoproteins and lipoprotein (a). |
15117885 | FASEB J. | 2004 | Danesh FR and Kanwar YS | Modulatory effects of HMG-CoA reductase inhibitors in diabetic microangiopathy. |
14745013 | Proc. Natl. Acad. Sci. U.S.A. | 2004 | Roth GE et al. | The Drosophila gene Start1: a putative cholesterol transporter and key regulator of ecdysteroid synthesis. |
14684813 | Science | 2003 | Wechsler A et al. | Generation of viable cholesterol-free mice. |
14694190 | Proc. Natl. Acad. Sci. U.S.A. | 2004 | Hojo Y et al. | Adult male rat hippocampus synthesizes estradiol from pregnenolone by cytochromes P45017alpha and P450 aromatase localized in neurons. |
15452192 | J. Pharmacol. Exp. Ther. | 2005 | Macias RI et al. | Long-term effect of treating pregnant rats with ursodeoxycholic acid on the congenital impairment of bile secretion induced in the pups by maternal cholestasis. |
21622796 | Appl. Environ. Microbiol. | 2011 | Drzyzga O et al. | Cholesterol degradation by Gordonia cholesterolivorans. |
21636783 | Proc. Natl. Acad. Sci. U.S.A. | 2011 | Strushkevich N et al. | Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system. |
21383147 | Proc. Natl. Acad. Sci. U.S.A. | 2011 | Hatori M et al. | Light-dependent and circadian clock-regulated activation of sterol regulatory element-binding protein, X-box-binding protein 1, and heat shock factor pathways. |
20921434 | Hypertension | 2010 | Barchiesi F et al. | Candidate genes and mechanisms for 2-methoxyestradiol-mediated vasoprotection. |
20924043 | Toxicol. Sci. | 2010 | Chen MC et al. | Stimulatory effects of propylthiouracil on pregnenolone production through upregulation of steroidogenic acute regulatory protein expression in rat granulosa cells. |
20876522 | J. Histochem. Cytochem. | 2011 | Hoshino H et al. | Membrane-associated activation of cholesterol α-glucosyltransferase, an enzyme responsible for biosynthesis of cholesteryl-α-D-glucopyranoside in Helicobacter pylori critical for its survival. |
20881306 | Invest. Ophthalmol. Vis. Sci. | 2011 | Mast N et al. | Cholestenoic Acid is an important elimination product of cholesterol in the retina: comparison of retinal cholesterol metabolism with that in the brain. |
21205902 | Proc. Natl. Acad. Sci. U.S.A. | 2011 | Schäfer LV et al. | Lipid packing drives the segregation of transmembrane helices into disordered lipid domains in model membranes. |
19176762 | Am. J. Physiol., Cell Physiol. | 2009 | Romanenko VG et al. | The role of cell cholesterol and the cytoskeleton in the interaction between IK1 and maxi-K channels. |
19179626 | Am. J. Physiol. Gastrointest. Liver Physiol. | 2009 | Leblond F et al. | Regulation of the proprotein convertase subtilisin/kexin type 9 in intestinal epithelial cells. |
18988759 | Drug Metab. Dispos. | 2009 | Miyata M et al. | Cholesterol feeding prevents hepatic accumulation of bile acids in cholic acid-fed farnesoid X receptor (FXR)-null mice: FXR-independent suppression of intestinal bile acid absorption. |
19299314 | Biol. Reprod. | 2009 | Palaniappan M and Menon KM | Regulation of sterol regulatory element-binding transcription factor 1a by human chorionic gonadotropin and insulin in cultured rat theca-interstitial cells. |
19713274 | Clin. Chem. | 2009 | Chan DC et al. | Plasma proprotein convertase subtilisin/kexin type 9: a marker of LDL apolipoprotein B-100 catabolism? |
19700418 | Carcinogenesis | 2009 | Calleros L et al. | Oncogenic Ras, but not (V600E)B-RAF, protects from cholesterol depletion-induced apoptosis through the PI3K/AKT pathway in colorectal cancer cells. |
19005074 | J. Neurosci. | 2008 | Tamboli IY et al. | Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis. |
19531574 | Mol. Cancer Ther. | 2009 | Trasino SE et al. | Ligand, receptor, and cell type-dependent regulation of ABCA1 and ABCG1 mRNA in prostate cancer epithelial cells. |
19541795 | Toxicol. Sci. | 2009 | Pogrmic K et al. | Atrazine oral exposure of peripubertal male rats downregulates steroidogenesis gene expression in Leydig cells. |
20360246 | Circ. Res. | 2010 | Naylor J et al. | Pregnenolone sulphate- and cholesterol-regulated TRPM3 channels coupled to vascular smooth muscle secretion and contraction. |
19880645 | Appl. Environ. Microbiol. | 2010 | Mathieu JM et al. | 7-ketocholesterol catabolism by Rhodococcus jostii RHA1. |
20015981 | J. Virol. | 2010 | Sharma M et al. | Inhibition of sterol biosynthesis reduces tombusvirus replication in yeast and plants. |
20413720 | Am. J. Physiol. Gastrointest. Liver Physiol. | 2010 | Coy DJ et al. | ABCG5/ABCG8-independent biliary cholesterol excretion in lactating rats. |
20304987 | J. Exp. Bot. | 2010 | Rossard S et al. | Ergosterol triggers characteristic elicitation steps in Beta vulgaris leaf tissues. |
20305089 | Mol. Cell Proteomics | 2010 | Jiang XS et al. | Quantitative proteomics analysis of inborn errors of cholesterol synthesis: identification of altered metabolic pathways in DHCR7 and SC5D deficiency. |
20584983 | Mol. Cell. Biol. | 2010 | Pankotai T et al. | Genes of the ecdysone biosynthesis pathway are regulated by the dATAC histone acetyltransferase complex in Drosophila. |
20056921 | Circ. Res. | 2010 | Blom T et al. | FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages. |
15321690 | FEMS Microbiol. Lett. | 2004 | Shimomura H et al. | Alteration in the composition of cholesteryl glucosides and other lipids in Helicobacter pylori undergoing morphological change from spiral to coccoid form. |
21921201 | J. Infect. Dis. | 2011 | Beigier-Bompadre M et al. | Modulation of the CD4+ T-cell response by Helicobacter pylori depends on known virulence factors and bacterial cholesterol and cholesterol α-glucoside content. |
17575085 | Diabetes | 2007 | Hao M et al. | Direct effect of cholesterol on insulin secretion: a novel mechanism for pancreatic beta-cell dysfunction. |
17428924 | Proc. Natl. Acad. Sci. U.S.A. | 2007 | Schekman R | How sterols regulate protein sorting and traffic. |
17347325 | J. Pharmacol. Exp. Ther. | 2007 | Pál A et al. | Cholesterol potentiates ABCG2 activity in a heterologous expression system: improved in vitro model to study function of human ABCG2. |
17470645 | J. Pharmacol. Exp. Ther. | 2007 | Sakamoto S et al. | Glucuronidation converting methyl 1-(3,4-dimethoxyphenyl)-3-(3-ethylvaleryl)-4-hydroxy-6,7,8-trimethoxy-2-naphthoate (S-8921) to a potent apical sodium-dependent bile acid transporter inhibitor, resulting in a hypocholesterolemic action. |
18039927 | FASEB J. | 2008 | Wang N et al. | ATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain. |
18187582 | Mol. Pharmacol. | 2008 | Weinglass AB et al. | Madin-Darby canine kidney II cells: a pharmacologically validated system for NPC1L1-mediated cholesterol uptake. |
18238900 | Proc. Natl. Acad. Sci. U.S.A. | 2008 | Kim HJ et al. | Liver X receptor beta (LXRbeta): a link between beta-sitosterol and amyotrophic lateral sclerosis-Parkinson's dementia. |
17823447 | Am. J. Clin. Nutr. | 2007 | Hansel B et al. | Effect of low-fat, fermented milk enriched with plant sterols on serum lipid profile and oxidative stress in moderate hypercholesterolemia. |
18367553 | Development | 2008 | Talamillo A et al. | Smt3 is required for Drosophila melanogaster metamorphosis. |
15590814 | Eukaryotic Cell | 2004 | Silver PM et al. | Role of Candida albicans transcription factor Upc2p in drug resistance and sterol metabolism. |
15621423 | FEMS Microbiol. Lett. | 2005 | Veiga P et al. | Correlation between faecal microbial community structure and cholesterol-to-coprostanol conversion in the human gut. |
15621432 | FEMS Microbiol. Lett. | 2005 | Hajjaj H et al. | Aspergillus oryzae produces compounds inhibiting cholesterol biosynthesis downstream of dihydrolanosterol. |
14976318 | Science | 2004 | Altmann SW et al. | Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption. |
16291572 | Am. J. Physiol. Endocrinol. Metab. | 2006 | Bilz S et al. | Activation of the farnesoid X receptor improves lipid metabolism in combined hyperlipidemic hamsters. |
16221727 | Development | 2005 | Huang X et al. | A Drosophila model of the Niemann-Pick type C lysosome storage disease: dnpc1a is required for molting and sterol homeostasis. |
16219690 | J. Cell. Sci. | 2005 | Churchward MA et al. | Cholesterol facilitates the native mechanism of Ca2+-triggered membrane fusion. |
16253212 | Cardiovasc. Res. | 2005 | Li D and Mehta JL | Oxidized LDL, a critical factor in atherogenesis. |
15492319 | Circulation | 2004 | O'Connell BJ et al. | Cellular physiology of cholesterol efflux in vascular endothelial cells. |
14769702 | Circulation | 2004 | Salen G et al. | Ezetimibe effectively reduces plasma plant sterols in patients with sitosterolemia. |
15673727 | Antimicrob. Agents Chemother. | 2005 | Xiong Q et al. | Cholesterol import by Aspergillus fumigatus and its influence on antifungal potency of sterol biosynthesis inhibitors. |
16000773 | Appl. Environ. Microbiol. | 2005 | Hajjaj H et al. | Effect of 26-oxygenosterols from Ganoderma lucidum and their activity as cholesterol synthesis inhibitors. |
16446309 | Hum. Mol. Genet. | 2006 | Correa-Cerro LS et al. | Development and characterization of a hypomorphic Smith-Lemli-Opitz syndrome mouse model and efficacy of simvastatin therapy. |
16452637 | Mol. Biol. Cell | 2006 | Ridsdale A et al. | Cholesterol is required for efficient endoplasmic reticulum-to-Golgi transport of secretory membrane proteins. |
17148218 | Biol. Lett. | 2005 | López P and Martín J | Female Iberian wall lizards prefer male scents that signal a better cell-mediated immune response. |
17135346 | J. Pharmacol. Exp. Ther. | 2007 | Yamanashi Y et al. | Niemann-Pick C1-like 1 overexpression facilitates ezetimibe-sensitive cholesterol and beta-sitosterol uptake in CaCo-2 cells. |
17158421 | Am. J. Clin. Nutr. | 2006 | Hallikainen M et al. | Interaction between cholesterol and glucose metabolism during dietary carbohydrate modification in subjects with the metabolic syndrome. |
16522906 | Am. J. Clin. Nutr. | 2006 | Naumann E et al. | Beta-glucan incorporated into a fruit drink effectively lowers serum LDL-cholesterol concentrations. |
16174794 | J. Pharmacol. Exp. Ther. | 2006 | Gong Y et al. | Niemann-Pick C1 protein facilitates the efflux of the anticancer drug daunorubicin from cells according to a novel vesicle-mediated pathway. |
16199524 | Proc. Natl. Acad. Sci. U.S.A. | 2005 | Xu F et al. | Dual roles for cholesterol in mammalian cells. |
17185355 | Gut | 2007 | Guarino MP et al. | Ursodeoxycholic acid improves muscle contractility and inflammation in symptomatic gallbladders with cholesterol gallstones. |
17220261 | Appl. Environ. Microbiol. | 2007 | Zhang S et al. | Identification of a sterol Delta7 reductase gene involved in desmosterol biosynthesis in Mortierella alpina 1S-4. |
17008555 | Am. J. Physiol. Gastrointest. Liver Physiol. | 2007 | Alrefai WA et al. | Modulation of human Niemann-Pick C1-like 1 gene expression by sterol: Role of sterol regulatory element binding protein 2. |
18499805 | J. Endocrinol. | 2008 | Böttner M et al. | Effects of long-term treatment with 8-prenylnaringenin and oral estradiol on the GH-IGF-1 axis and lipid metabolism in rats. |
18772220 | Brain | 2008 | Leoni V et al. | Plasma 24S-hydroxycholesterol and caudate MRI in pre-manifest and early Huntington's disease. |
18063707 | Am. J. Physiol. Gastrointest. Liver Physiol. | 2008 | Annaba F et al. | Modulation of ileal bile acid transporter (ASBT) activity by depletion of plasma membrane cholesterol: association with lipid rafts. |
22628034 | Am. J. Physiol. Gastrointest. Liver Physiol. | 2012 | Jones RD et al. | Delineation of biochemical, molecular, and physiological changes accompanying bile acid pool size restoration in Cyp7a1(-/-) mice fed low levels of cholic acid. |
22556147 | Am. J. Physiol. Gastrointest. Liver Physiol. | 2012 | Henkel AS et al. | Reducing endoplasmic reticulum stress does not improve steatohepatitis in mice fed a methionine- and choline-deficient diet. |
22535758 | J. Nutr. | 2012 | Brauner R et al. | Phytosterols reduce cholesterol absorption by inhibition of 27-hydroxycholesterol generation, liver X receptor α activation, and expression of the basolateral sterol exporter ATP-binding cassette A1 in Caco-2 enterocytes. |
21940599 | Am. J. Clin. Nutr. | 2011 | Paramsothy P et al. | Plasma sterol evidence for decreased absorption and increased synthesis of cholesterol in insulin resistance and obesity. |
22343944 | EMBO J. | 2012 | Sodero AO et al. | Cholesterol loss during glutamate-mediated excitotoxicity. |
22923735 | J. Pharmacol. Exp. Ther. | 2012 | Marriott KS et al. | σ-1 receptor at the mitochondrial-associated endoplasmic reticulum membrane is responsible for mitochondrial metabolic regulation. |
22977134 | Invest. Ophthalmol. Vis. Sci. | 2012 | Fourgeux C et al. | Single nucleotide polymorphism in the cholesterol-24S-hydroxylase (CYP46A1) gene and its association with CFH and LOC387715 gene polymorphisms in age-related macular degeneration. |
22156476 | Biol. Reprod. | 2012 | Bogan RL et al. | Liver x receptor modulation of gene expression leading to proluteolytic effects in primate luteal cells. |
22461539 | Clin J Am Soc Nephrol | 2012 | Rogacev KS et al. | Cholesterol synthesis, cholesterol absorption, and mortality in hemodialysis patients. |
22396595 | Proc. Natl. Acad. Sci. U.S.A. | 2012 | Shi Z and Ruvkun G | The mevalonate pathway regulates microRNA activity in Caenorhabditis elegans. |
23475705 | Eukaryotic Cell | 2013 | Zavrel M et al. | Comparison of sterol import under aerobic and anaerobic conditions in three fungal species, Candida albicans, Candida glabrata, and Saccharomyces cerevisiae. |
23115269 | Biol. Reprod. | 2013 | Boerke A et al. | Involvement of bicarbonate-induced radical signaling in oxysterol formation and sterol depletion of capacitating mammalian sperm during in vitro fertilization. |
23139217 | Am. J. Physiol. Gastrointest. Liver Physiol. | 2013 | Henkel AS et al. | Hepatic overexpression of Abcb11 in mice promotes the conservation of bile acids within the enterohepatic circulation. |
23027975 | Proc. Natl. Acad. Sci. U.S.A. | 2012 | Choudhary V and Schneiter R | Pathogen-Related Yeast (PRY) proteins and members of the CAP superfamily are secreted sterol-binding proteins. |
23530189 | Proc. Natl. Acad. Sci. U.S.A. | 2013 | Rauthan M et al. | The mitochondrial unfolded protein response activator ATFS-1 protects cells from inhibition of the mevalonate pathway. |
24174662 | J. Neurosci. | 2013 | Paul SM et al. | The major brain cholesterol metabolite 24(S)-hydroxycholesterol is a potent allosteric modulator of N-methyl-D-aspartate receptors. |
24085193 | Toxicol. Sci. | 2014 | Nakano-Ito K et al. | E2012-induced cataract and its predictive biomarkers. |
24107941 | J. Neurosci. | 2013 | Burg VK et al. | Plant sterols the better cholesterol in Alzheimer's disease? A mechanistical study. |
23811185 | J. Gerontol. A Biol. Sci. Med. Sci. | 2014 | Sanders JL et al. | Do changes in circulating biomarkers track with each other and with functional changes in older adults? |
17409448 | Cancer Res. | 2007 | Sánchez-Martín CC et al. | Cholesterol starvation induces differentiation of human leukemia HL-60 cells. |
10428760 | FASEB J. | 1999 | Martínez-Botas J et al. | Cholesterol starvation decreases p34(cdc2) kinase activity and arrests the cell cycle at G2. |
20102935 | Am. J. Cardiol. | 2010 | LaRosa JC et al. | Comparison of 80 versus 10 mg of atorvastatin on occurrence of cardiovascular events after the first event (from the Treating to New Targets [TNT] trial). |
19087351 | Cardiovasc Ultrasound | 2008 | Takase B et al. | Endothelial dysfunction, carotid artery plaque burden, and conventional exercise-induced myocardial ischemia as predictors of coronary artery disease prognosis. |
18591872 | Yakugaku Zasshi | 2008 | Miyamura M et al. | [Inhibitory effects of "Goishi-tea" as a post-fermented-tea on dietary-induced hypercholesteremia and atherosclerosis in rabbits]. |
18366711 | BMC Health Serv Res | 2008 | Sheridan SL and Crespo E | Does the routine use of global coronary heart disease risk scores translate into clinical benefits or harms? A systematic review of the literature. |
18308675 | Diabetes Care | 2008 | Sakurai M et al. | BMI may be better than waist circumference for defining metabolic syndrome in Japanese women. |
18055147 | J Ethnopharmacol | 2008 | Rasekh HR et al. | Acute and subchronic oral toxicity of Galega officinalis in rats. |
18045100 | Curr Drug Targets | 2007 | Péterfy M et al. | Metabolic syndrome as a modifier of atherosclerosis in murine models. |
17803693 | Clin. Endocrinol. (Oxf) | 2008 | Catalán V et al. | Expression of caveolin-1 in human adipose tissue is upregulated in obesity and obesity-associated type 2 diabetes mellitus and related to inflammation. |
17719330 | Am. J. Cardiol. | 2007 | Campbell CY et al. | Combined effect of high low-density lipoprotein cholesterol and metabolic syndrome on subclinical coronary atherosclerosis in white men without clinical evidence of myocardial ischemia. |
17534610 | Anal Bioanal Chem | 2007 | Sharpless KE et al. | Standard reference materials for foods and dietary supplements. |
17168712 | Curr. Med. Chem. | 2006 | de Lorenzo F et al. | Statin therapy-evidence beyond lipid lowering contributing to plaque stability. |
16889997 | Nitric Oxide | 2007 | Osawa M et al. | Nitric oxide (NO) is a new clinical biomarker of survival in the elderly patients and its efficacy might be nearly equal to albumin. |
16396382 | J Spinal Cord Med | 2005 | Nash MS et al. | Evidence for an exaggerated postprandial lipemia in chronic paraplegia. |
16220065 | J. Cardiovasc. Pharmacol. | 2005 | McKenney JM et al. | Use of a treatment algorithm to achieve NCEP ATP III goals with atorvastatin. |
16165006 | Womens Health Issues | Pullen CH et al. | Differences in eating and activity markers among normal weight, overweight, and obese rural women. |