7-Dehydrocholesterol

7-Dehydrocholesterol is a lipid of Sterol Lipids (ST) class. 7-dehydrocholesterol is associated with abnormalities such as Dehydration, Exanthema, RETINITIS PIGMENTOSA 49, Congenital Abnormality and Failure to Thrive. The involved functions are known as 5-(carboxyamino)imidazole ribonucleotide mutase activity, Mutation, Lysis, Anabolism and Biosynthetic Pathways. 7-dehydrocholesterol often locates in Plasma membrane, Body tissue, Tissue membrane, Membrane and outer membrane. The associated genes with 7-Dehydrocholesterol are mutant gene, THEMIS gene, IGKV1D-37 gene, LGALS4 gene and Orthologous Gene. The related lipids are Membrane Lipids, Steroids, Sterols, campesterol and 7-dehydrocholesterol. The related experimental models are Mouse Model, Knock-out and Rodent Model.

References related to locations published in Others


PMIDJournalPublished DateAuthorTitle
20558592Mol. Pharmacol.2010Lauth M et al.Antipsychotic drugs regulate hedgehog signaling by modulation of 7-dehydrocholesterol reductase levels.
23144252J. Bacteriol.2013Shimomura H et al.Detoxification of 7-dehydrocholesterol fatal to Helicobacter pylori is a novel role of cholesterol glucosylation.
22106170Drug Metab. Dispos.2012Tuckey RC et al.Human cytochrome P450scc (CYP11A1) catalyzes epoxide formation with ergosterol.
21762780J. Steroid Biochem. Mol. Biol.2011Zou L et al.7-Dehydrocholesterol reductase activity is independent of cytochrome P450 reductase.
21441443Diabetes2011Cooper JD et al.Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes.
20153720Biochim. Biophys. Acta2010Cui ZK et al.Influence of the nature of the sterol on the behavior of palmitic acid/sterol mixtures and their derived liposomes.
20018479J. Autoimmun.2010Maverakis E et al.Light, including ultraviolet.
19667162Anticancer Res.2009Seifert M et al.Expression of 25-hydroxyvitamin D-1alpha-hydroxylase (1alphaOHase, CYP27B1) splice variants in HaCaT keratinocytes and other skin cells: modulation by culture conditions and UV-B treatment in vitro.
11901095Drug Metab. Dispos.2002Kitamura S et al.Reductive metabolism of an alpha,beta-ketoalkyne, 4-phenyl-3-butyn-2-one, by rat liver preparations.
26854824Exp. Eye Res.2016Pfeffer BA et al.Differential cytotoxic effects of 7-dehydrocholesterol-derived oxysterols on cultured retina-derived cells: Dependence on sterol structure, cell type, and density.
26214382J. Invest. Dermatol.2015Xue Y et al.Androgens Attenuate Vitamin D Production Induced by UVB Irradiation of the Skin of Male Mice by an Enzymatic Mechanism.
25448732J. Steroid Biochem. Mol. Biol.2015Slominski AT et al.Novel activities of CYP11A1 and their potential physiological significance.