lysophosphatidic acid is a lipid of Glycerophospholipids (GP) class. Lysophosphatidic acid is associated with abnormalities such as Atherosclerosis, Alzheimer's Disease, Asthma, Diabetes Mellitus, Non-Insulin-Dependent and Septicemia. The involved functions are known as Inflammation, Chemotaxis, Binding (Molecular Function), Polymerization and Inflammatory Response. Lysophosphatidic acid often locates in Cytoskeleton, Microfilaments, actin cytoskeleton, Extracellular and Structure of germinal center of lymph node. The associated genes with lysophosphatidic acid are TNF gene, MAPK3 gene, RHOA gene, CDC42 gene and ADRBK1 gene. The related lipids are lysophosphatidic acid, Lipopolysaccharides, Lysophosphatidylcholines, Lysophospholipids and Phosphatidic Acid. The related experimental models are Knock-out, Transgenic Model, Rodent Model and Disease model.
PMID | Journal | Published Date | Author | Title |
---|---|---|---|---|
25033840 | Mol. Cancer Res. | 2014 | Schneider G et al. | Bioactive lipids, LPC and LPA, are novel prometastatic factors and their tissue levels increase in response to radio/chemotherapy. |
28588064 | EMBO J. | 2017 | Aikawa S et al. | Autotaxin-lysophosphatidic acid-LPA3 signaling at the embryo-epithelial boundary controls decidualization pathways. |
27641493 | Neuron | 2016 | Cheng J et al. | Precise Somatotopic Thalamocortical Axon Guidance Depends on LPA-Mediated PRG-2/Radixin Signaling. |
27453502 | Dev. Cell | 2016 | Liu X et al. | PRG-1 Regulates Synaptic Plasticity via Intracellular PP2A/β1-Integrin Signaling. |
27401461 | Physiol Rep | 2016 | Sweat RS et al. | Lysophosphatidic acid does not cause blood/lymphatic vessel plasticity in the rat mesentery culture model. |
27161483 | Cell Chem Biol | 2016 | Hövelmann F et al. | Optotaxis: Caged Lysophosphatidic Acid Enables Optical Control of a Chemotactic Gradient. |
27050949 | Stem Cell Reports | 2016 | Walker TL et al. | Lysophosphatidic Acid Receptor Is a Functional Marker of Adult Hippocampal Precursor Cells. |
27030671 | Mol. Biol. Cell | 2016 | Bartolini F et al. | An mDia1-INF2 formin activation cascade facilitated by IQGAP1 regulates stable microtubules in migrating cells. |
27013613 | Arterioscler. Thromb. Vasc. Biol. | 2016 | Ren B et al. | LPA/PKD-1-FoxO1 Signaling Axis Mediates Endothelial Cell CD36 Transcriptional Repression and Proangiogenic and Proarteriogenic Reprogramming. |
27006447 | FASEB J. | 2016 | Black KE et al. | Autotaxin activity increases locally following lung injury, but is not required for pulmonary lysophosphatidic acid production or fibrosis. |
26947063 | Cell Rep | 2016 | Qin H et al. | YAP Induces Human Naive Pluripotency. |
26671989 | EMBO Mol Med | 2016 | Vogt J et al. | Molecular cause and functional impact of altered synaptic lipid signaling due to a prg-1 gene SNP. |
26597701 | Biochim. Biophys. Acta | 2016 | Nan L et al. | Cross-talk between lysophosphatidic acid receptor 1 and tropomyosin receptor kinase A promotes lung epithelial cell migration. |
26476080 | Neoplasia | 2015 | Mukherjee A et al. | Lysophosphatidic Acid Up-Regulates Hexokinase II and Glycolysis to Promote Proliferation of Ovarian Cancer Cells. |
26345369 | J. Cell. Sci. | 2015 | Yukiura H et al. | LPP3 localizes LPA6 signalling to non-contact sites in endothelial cells. |
26269646 | J. Neurosci. | 2015 | Wheeler NA et al. | The Autotaxin-Lysophosphatidic Acid Axis Modulates Histone Acetylation and Gene Expression during Oligodendrocyte Differentiation. |
26180199 | J. Neurosci. | 2015 | Santos-Nogueira E et al. | Activation of Lysophosphatidic Acid Receptor Type 1 Contributes to Pathophysiology of Spinal Cord Injury. |
26101324 | J. Immunol. | 2015 | McArthur S et al. | Definition of a Novel Pathway Centered on Lysophosphatidic Acid To Recruit Monocytes during the Resolution Phase of Tissue Inflammation. |
26041536 | J. Immunol. | 2015 | Causton B et al. | CARMA3 Is Critical for the Initiation of Allergic Airway Inflammation. |
25934709 | Mol. Cancer Ther. | 2015 | Xia Y et al. | Rho Kinase Inhibitor Fasudil Suppresses the Vasculogenic Mimicry of B16 Mouse Melanoma Cells Both In Vitro and In Vivo. |
25855080 | Am. J. Physiol., Cell Physiol. | 2015 | No YR et al. | Regulation of NHE3 by lysophosphatidic acid is mediated by phosphorylation of NHE3 by RSK2. |
25852197 | Development | 2015 | Sheng X et al. | Lysophosphatidic acid signalling in development. |
25695267 | Neuron | 2015 | Yung YC et al. | Lysophosphatidic Acid signaling in the nervous system. |
25619933 | Chem. Biol. | 2015 | Patil R et al. | Combined mitigation of the gastrointestinal and hematopoietic acute radiation syndromes by an LPA2 receptor-specific nonlipid agonist. |
25555354 | Prostaglandins Leukot. Essent. Fatty Acids | 2015 | Block RC et al. | The effects of aspirin on platelet function and lysophosphatidic acids depend on plasma concentrations of EPA and DHA. |
25464168 | Osteoarthr. Cartil. | 2015 | Wu L et al. | Lysophosphatidic acid mediates fibrosis in injured joints by regulating collagen type I biosynthesis. |
25451317 | Cancer Lett. | 2015 | Ward JD et al. | LPA-mediated migration of ovarian cancer cells involves translocalization of Gαi2 to invadopodia and association with Src and β-pix. |
25425621 | Arterioscler. Thromb. Vasc. Biol. | 2015 | Kurano M et al. | Possible involvement of minor lysophospholipids in the increase in plasma lysophosphatidic acid in acute coronary syndrome. |
25344254 | J. Cell. Sci. | 2014 | Argenzio E et al. | CLIC4 regulates cell adhesion and β1 integrin trafficking. |
25277122 | Blood | 2014 | Leblanc R et al. | Interaction of platelet-derived autotaxin with tumor integrin αVβ3 controls metastasis of breast cancer cells to bone. |
24750398 | HPB (Oxford) | 2014 | Simo KA et al. | Altered lysophosphatidic acid (LPA) receptor expression during hepatic regeneration in a mouse model of partial hepatectomy. |
24657741 | Free Radic. Biol. Med. | 2014 | Klomsiri C et al. | Endosomal H2O2 production leads to localized cysteine sulfenic acid formation on proteins during lysophosphatidic acid-mediated cell signaling. |
24455753 | Cancer Immunol Res | 2013 | Oda SK et al. | Lysophosphatidic acid inhibits CD8 T cell activation and control of tumor progression. |
24445011 | J. Formos. Med. Assoc. | 2014 | Wang CY et al. | Epigallocatechin-3-gallate inhibits lysophosphatidic acid-stimulated connective tissue growth factor via JNK and Smad3 suppression in human gingival fibroblasts. |