Ganglioside GM2 is a lipid of Sphingolipids (SP) class. Ganglioside gm2 is associated with abnormalities such as Sensory neuropathy, Neuropathy, Autoimmune Diseases, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating and Neuromuscular Diseases. The involved functions are known as Pressure- physical agent, Cytolysis, Inflammation, Complement-Dependent Cytotoxicity and conjugation. Ganglioside gm2 often locates in Membrane, Entire nervous system, Cell surface, Biopsy sample and Lipid Bilayers. The associated genes with Ganglioside GM2 are anti-IgM, Polypeptides, Transgenes, Alleles and Homologous Gene. The related lipids are Ganglioside GA2, QS 21, sulfate-3-glucuronyl paragloboside, Lipopolysaccharides and IV(4)-galactosyl-N-acetylganglioside GD1a. The related experimental models are Disease model.
PMID | Journal | Published Date | Author | Title |
---|---|---|---|---|
25425650 | J. Biol. Chem. | 2015 | Grey M et al. | Acceleration of α-synuclein aggregation by exosomes. |
14871967 | Clin. Cancer Res. | 2004 | Krug LM et al. | Vaccination of small cell lung cancer patients with polysialic acid or N-propionylated polysialic acid conjugated to keyhole limpet hemocyanin. |
11796728 | J. Biol. Chem. | 2002 | Miljan EA et al. | Interaction of the extracellular domain of the epidermal growth factor receptor with gangliosides. |
11358851 | Cancer Res. | 2001 | Yoshida S et al. | Ganglioside G(D2) in small cell lung cancer cell lines: enhancement of cell proliferation and mediation of apoptosis. |
27923633 | Brain Res. | 2017 | Trilck M et al. | Diversity of glycosphingolipid GM2 and cholesterol accumulation in NPC1 patient-specific iPSC-derived neurons. |
27491075 | Dis Model Mech | 2016 | Wolf H et al. | A mouse model for fucosidosis recapitulates storage pathology and neurological features of the milder form of the human disease. |
26175473 | J. Lipid Res. | 2015 | Anheuser S et al. | Membrane lipids regulate ganglioside GM2 catabolism and GM2 activator protein activity. |
25873306 | ASN Neuro | Rockwell HE et al. | AAV-mediated gene delivery in a feline model of Sandhoff disease corrects lysosomal storage in the central nervous system. | |
25717099 | Sci Transl Med | 2015 | Vite CH et al. | Intracisternal cyclodextrin prevents cerebellar dysfunction and Purkinje cell death in feline Niemann-Pick type C1 disease. |
24769373 | Anal. Biochem. | 2014 | Fuller M et al. | Liquid chromatography/electrospray ionisation-tandem mass spectrometry quantification of GM2 gangliosides in human peripheral cells and plasma. |
23401234 | Synapse | 2013 | Rupp A et al. | The effects of age and ganglioside composition on the rate of motor nerve terminal regeneration following antibody-mediated injury in mice. |
22372857 | J. Neurochem. | 2012 | Saito M et al. | Elevation of GM2 ganglioside during ethanol-induced apoptotic neurodegeneration in the developing mouse brain. |
21487393 | Mol. Ther. | 2011 | Matsuoka K et al. | Therapeutic potential of intracerebroventricular replacement of modified human β-hexosaminidase B for GM2 gangliosidosis. |
20187655 | ACS Chem. Biol. | 2010 | Ho CW et al. | Development of GlcNAc-inspired iminocyclitiols as potent and selective N-acetyl-beta-hexosaminidase inhibitors. |
19706290 | Biochem. Biophys. Res. Commun. | 2009 | Tomioka R et al. | Neuroblastoma GOTO cells are hypersensitive to disruption of lipid rafts. |
18657867 | J. Neuroimmunol. | 2008 | Kyrkanides S et al. | Peripheral blood mononuclear cell infiltration and neuroinflammation in the HexB-/- mouse model of neurodegeneration. |
17967427 | Biochim. Biophys. Acta | 2008 | Li YT et al. | Effect of structural modifications of ganglioside GM2 on intra-molecular carbohydrate-to-carbohydrate interaction and enzymatic susceptibility. |
17253773 | Biochemistry | 2007 | Martinez Z et al. | GM1 specifically interacts with alpha-synuclein and inhibits fibrillation. |
17198760 | J. Feline Med. Surg. | 2007 | Hasegawa D et al. | Clinical and molecular analysis of GM2 gangliosidosis in two apparent littermate kittens of the Japanese domestic cat. |
17196574 | Clin. Chim. Acta | 2007 | Tsuji D et al. | Therapeutic evaluation of GM2 gangliosidoses by ELISA using anti-GM2 ganglioside antibodies. |
16620986 | Mol. Immunol. | 2007 | López-Requena A et al. | Gangliosides, Ab1 and Ab2 antibodies II. Light versus heavy chain: An idiotype-anti-idiotype case study. |
16569450 | Mol. Biochem. Parasitol. | 2006 | Bruce AF et al. | Functional characterisation of a nematode secreted GM2-activator protein. |
16478472 | FEBS J. | 2006 | Wendeler M et al. | The enzyme-binding region of human GM2-activator protein. |
16200419 | Acta Neuropathol. | 2005 | Martin DR et al. | Mutation of the GM2 activator protein in a feline model of GM2 gangliosidosis. |
15953731 | Neurobiol. Dis. | 2005 | Arfi A et al. | Bicistronic lentiviral vector corrects beta-hexosaminidase deficiency in transduced and cross-corrected human Sandhoff fibroblasts. |
15178323 | FEBS Lett. | 2004 | Aoki H et al. | Inhibition of motility and invasiveness of renal cell carcinoma induced by short interfering RNA transfection of beta 1,4GalNAc transferase. |
12740812 | Chembiochem | 2003 | Antoine T et al. | Large-scale in vivo synthesis of the carbohydrate moieties of gangliosides GM1 and GM2 by metabolically engineered Escherichia coli. |
12705795 | Intern. Med. | 2003 | Mizutani K et al. | Amyotrophic lateral sclerosis with IgM antibody against gangliosides GM2 and GD2. |
12455030 | Int. J. Cancer | 2003 | Chen HH et al. | Suppression of lung metastasis of mouse Lewis lung cancer P29 with transfection of the ganglioside GM2/GD2 synthase gene. |
11578853 | Brain Dev. | 2001 | Taniguchi M et al. | Sites and temporal changes of gangliosides GM1/GM2 storage in the Niemann-Pick disease type C mouse brain. |
11560770 | Hum. Gene Ther. | 2001 | Teixeira CA et al. | Retrovirus-mediated transfer and expression of beta-hexosaminidase alpha-chain cDNA in human fibroblasts from G(M2)-gangliosidosis B1 variant. |
11230488 | J. Clin. Oncol. | 2001 | Kirkwood JM et al. | High-dose interferon alfa-2b does not diminish antibody response to GM2 vaccination in patients with resected melanoma: results of the Multicenter Eastern Cooperative Oncology Group Phase II Trial E2696. |
11064828 | Clin Rev Allergy Immunol | 2000 | Portoukalian J | Immunogenicity of glycolipids. |
10571007 | Biochim. Biophys. Acta | 1999 | Mahuran DJ | Biochemical consequences of mutations causing the GM2 gangliosidoses. |
10529115 | Microbiol. Immunol. | 1999 | Okada N et al. | Human IgM monoclonal antibody to ganglioside GM2 and complement suppress virus propagation in ex vivo cultures of lymphocytes from HIV-1 infected patients. |
10497993 | Am. J. Trop. Med. Hyg. | 1999 | Gori AH et al. | Mediation of attachment of Burkholderia pseudomallei to human pharyngeal epithelial cells by the asialoganglioside GM1-GM2 receptor complex. |
10073593 | J. Am. Soc. Nephrol. | 1999 | Mundel TM et al. | Ganglioside GM2-activator protein and vesicular transport in collecting duct intercalated cells. |
9989797 | J. Invest. Dermatol. | 1999 | Takahashi T et al. | IgM anti-ganglioside antibodies induced by melanoma cell vaccine correlate with survival of melanoma patients. |
9972876 | Neurochem. Res. | 1999 | Usuki S et al. | GM2 promotes ciliary neurotrophic factor-dependent rescue of immortalized motor neuron-like cell (NSC-34). |
9728970 | J. Neurol. Neurosurg. Psychiatry | 1998 | Tsukaguchi M et al. | IgM anti-GM2 antibody in a patient with Guillain-Barré syndrome subsequent to cytomegalovirus hepatitis cross reacts with N-acetylgalactosaminyl GD1a. |
9572057 | Mol Med Today | 1998 | Chavany C and Jendoubi M | Biology and potential strategies for the treatment of GM2 gangliosidoses. |
9435988 | Clin. Chim. Acta | 1997 | Sandhoff K and Kolter T | Biochemistry of glycosphingolipid degradation. |
9153001 | Neurochem. Int. | 1997 | Nakamura K et al. | Gangliosides of dogfish (Squalus acanthias) brain. |
8544979 | Neuroscience | 1995 | Walkley SU | Pyramidal neurons with ectopic dendrites in storage diseases exhibit increased GM2 ganglioside immunoreactivity. |
7590782 | Hybridoma | 1995 | Alfonso M et al. | T cell-independent B cell response to self-monosialogangliosides: primary response monoclonal antibodies. |
1291049 | Carbohydr. Res. | 1992 | Schaeper RJ et al. | In vitro biosynthesis of GbOse4Cer (globoside) and GM2 ganglioside by the (1-->3) and (1-->4)-N-acetyl beta-D-galactosaminyltransferases from embryonic chicken brain. Solubilization, purification, and characterization of the transferases. |
2709011 | J. Neurochem. | 1989 | Riboni L et al. | Formation of ganglioside GD1b-lactone in rat brain from intracisternally administered GD1b. |