2-arachidonoylglycerol

2-arachidonoylglycerol is a lipid of Glycerolipids (GL) class. 2-arachidonoylglycerol is associated with abnormalities such as Atherosclerosis, Heart Diseases, Inflammatory disorder, Colitis and Peripheral Neuropathy. The involved functions are known as Immunoreactivity, inhibitors, Stimulus, Esthesia and Signal Transduction. 2-arachidonoylglycerol often locates in Back, Presynaptic Terminals, Brain region, Blood and Body tissue. The associated genes with 2-arachidonoylglycerol are ADRBK1 gene, Homologous Gene, MGLL gene, PLA2G4A gene and peptide V. The related lipids are oleoylethanolamide, Lipopolysaccharides, Promega, stearic acid and 1-stearoyl-2-arachidonoylglycerol. The related experimental models are Knock-out.

References related to locations published in Others

PMID	Journal	Published Date	Author	Title
26956082	Biochim. Biophys. Acta	2016	Leishman E et al.	Lipidomics profile of a NAPE-PLD KO mouse provides evidence of a broader role of this enzyme in lipid metabolism in the brain.
26698193	Biol. Psychiatry	2016	Lu HC and Mackie K	An Introduction to the Endogenous Cannabinoid System.
26180248	J. Nutr.	2015	Mennella I et al.	Food Liking Enhances the Plasma Response of 2-Arachidonoylglycerol and of Pancreatic Polypeptide upon Modified Sham Feeding in Humans.
25877930	J. Leukoc. Biol.	2015	Turcotte C et al.	Regulation of inflammation by cannabinoids, the endocannabinoids 2-arachidonoyl-glycerol and arachidonoyl-ethanolamide, and their metabolites.
25640062	J. Hepatol.	2015	Gaskari SA et al.	Blunted cardiac response to hemorrhage in cirrhotic rats is mediated by local macrophage-released endocannabinoids.
25489086	Proc. Natl. Acad. Sci. U.S.A.	2014	Morena M et al.	Endogenous cannabinoid release within prefrontal-limbic pathways affects memory consolidation of emotional training.
25304184	Pharmacol. Res.	2014	Khasabova IA et al.	JZL184 is anti-hyperalgesic in a murine model of cisplatin-induced peripheral neuropathy.
25037227	J. Biol. Chem.	2014	Laprairie RB et al.	Type 1 cannabinoid receptor ligands display functional selectivity in a cell culture model of striatal medium spiny projection neurons.
24709540	Neuropharmacology	2014	Nader J et al.	Prior stimulation of the endocannabinoid system prevents methamphetamine-induced dopaminergic neurotoxicity in the striatum through activation of CB2 receptors.
24704332	Int. J. Infect. Dis.	2014	Sun LJ et al.	Endocannabinoid system activation contributes to glucose metabolism disorders of hepatocytes and promotes hepatitis C virus replication.
24529672	Acta Anaesthesiol Taiwan	2013	Chiou LC et al.	Targeting the cannabinoid system for pain relief?
28262417	Neuron	2017	Gantz SC and Bean BP	Cell-Autonomous Excitation of Midbrain Dopamine Neurons by Endocannabinoid-Dependent Lipid Signaling.
27133395	Gastroenterology	2016	Sharkey KA and Wiley JW	The Role of the Endocannabinoid System in the Brain-Gut Axis.
26989199	Science	2016	Miller MR et al.	Unconventional endocannabinoid signaling governs sperm activation via the sex hormone progesterone.
26668358	Proc. Natl. Acad. Sci. U.S.A.	2016	Ogasawara D et al.	Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition.
26584135	Atherosclerosis	2016	Vujic N et al.	Monoglyceride lipase deficiency modulates endocannabinoid signaling and improves plaque stability in ApoE-knockout mice.
26408049	Exp. Neurol.	2015	Zheng G et al.	Chronic stress and peripheral pain: Evidence for distinct, region-specific changes in visceral and somatosensory pain regulatory pathways.
26365195	Cell Rep	2015	Wang H et al.	Cocaine-Induced Endocannabinoid Mobilization in the Ventral Tegmental Area.
26290104	Am. J. Physiol. Regul. Integr. Comp. Physiol.	2015	DiPatrizio NV et al.	Fasting stimulates 2-AG biosynthesis in the small intestine: role of cholinergic pathways.
26244281	Exp. Neurol.	2015	Mounsey RB et al.	Increasing levels of the endocannabinoid 2-AG is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.
26212325	Cell Rep	2015	Viader A et al.	Metabolic Interplay between Astrocytes and Neurons Regulates Endocannabinoid Action.
26210060	Biol. Psychiatry	2016	Volk DW and Lewis DA	The Role of Endocannabinoid Signaling in Cortical Inhibitory Neuron Dysfunction in Schizophrenia.
26037800	Neuroscience	2015	Hutch CR et al.	An endocannabinoid system is present in the mouse olfactory epithelium but does not modulate olfaction.
26000748	Chem. Biol.	2015	Dotsey EY et al.	Peroxide-Dependent MGL Sulfenylation Regulates 2-AG-Mediated Endocannabinoid Signaling in Brain Neurons.
25776459	J. Nutr. Biochem.	2015	Midtbø LK et al.	Intake of farmed Atlantic salmon fed soybean oil increases hepatic levels of arachidonic acid-derived oxylipins and ceramides in mice.
25484252	Neuropharmacology	2015	Shonesy BC et al.	The initiation of synaptic 2-AG mobilization requires both an increased supply of diacylglycerol precursor and increased postsynaptic calcium.
25466252	Cell Rep	2014	Shonesy BC et al.	Genetic disruption of 2-arachidonoylglycerol synthesis reveals a key role for endocannabinoid signaling in anxiety modulation.
24882055	Semin. Immunol.	2014	Hillard CJ	Stress regulates endocannabinoid-CB1 receptor signaling.
24548820	Pharmacol. Res.	2014	Stanley CP and O'Sullivan SE	Cyclooxygenase metabolism mediates vasorelaxation to 2-arachidonoylglycerol (2-AG) in human mesenteric arteries.