DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

References related to locations published in Others

PMID	Journal	Published Date	Author	Title
8702792	J. Biol. Chem.	1996	Chen Y et al.	Docosahexaenoic acid modulates the interactions of the interphotoreceptor retinoid-binding protein with 11-cis-retinal.
10375002	Mutagenesis	1999	Higgins S et al.	Effects of oleic acid, docosahexaenoic acid and eicosapentaenoic acid on background and genotoxin-induced frequencies of SCEs in Indian muntjac fibroblasts.
9637532	J. Immunol.	1998	Cadroy Y et al.	Arachidonic acid enhances the tissue factor expression of mononuclear cells by the cyclo-oxygenase-1 pathway: beneficial effect of n-3 fatty acids.
11352806	Am. J. Physiol. Gastrointest. Liver Physiol.	2001	Wang H et al.	Regulation of apolipoprotein secretion by long-chain polyunsaturated fatty acids in newborn swine enterocytes.
12912821	Circulation	2003	Dallongeville J et al.	Fish consumption is associated with lower heart rates.
10982541	Circulation	2000	Mori TA et al.	Differential effects of eicosapentaenoic acid and docosahexaenoic acid on vascular reactivity of the forearm microcirculation in hyperlipidemic, overweight men.
14583629	J. Biol. Chem.	2004	Madani S et al.	Diacylglycerols containing Omega 3 and Omega 6 fatty acids bind to RasGRP and modulate MAP kinase activation.
15358633	Carcinogenesis	2004	Calviello G et al.	n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE2 induced ERK-1 and -2 and HIF-1alpha induction pathway.
15326218	J. Exp. Biol.	2004	Van Anholt RD et al.	Arachidonic acid reduces the stress response of gilthead seabream Sparus aurata L.
20732876	J. Biol. Chem.	2010	Arnold C et al.	Arachidonic acid-metabolizing cytochrome P450 enzymes are targets of {omega}-3 fatty acids.
20702831	Invest. Ophthalmol. Vis. Sci.	2010	Matesanz N et al.	Docosahexaenoic acid improves the nitroso-redox balance and reduces VEGF-mediated angiogenic signaling in microvascular endothelial cells.
21653234	J. Leukoc. Biol.	2011	Palmer CD et al.	17(R)-Resolvin D1 differentially regulates TLR4-mediated responses of primary human macrophages to purified LPS and live E. coli.
21393477	Carcinogenesis	2011	Grant GE et al.	Enhanced formation of 5-oxo-6,8,11,14-eicosatetraenoic acid by cancer cells in response to oxidative stress, docosahexaenoic acid and neutrophil-derived 5-hydroxy-6,8,11,14-eicosatetraenoic acid.
21478260	FASEB J.	2011	Hellmann J et al.	Resolvin D1 decreases adipose tissue macrophage accumulation and improves insulin sensitivity in obese-diabetic mice.
21460209	J. Immunol.	2011	Norling LV et al.	Cutting edge: Humanized nano-proresolving medicines mimic inflammation-resolution and enhance wound healing.
21217086	Cancer Epidemiol. Biomarkers Prev.	2011	van der Pols JC et al.	Serum omega-3 and omega-6 fatty acids and cutaneous p53 expression in an Australian population.
21156816	J. Pharmacol. Exp. Ther.	2011	Li X et al.	Docosahexanoic acid-induced coronary arterial dilation: actions of 17S-hydroxy docosahexanoic acid on K+ channel activity.
19234220	J. Immunol.	2009	Hassan IR and Gronert K	Acute changes in dietary omega-3 and omega-6 polyunsaturated fatty acids have a pronounced impact on survival following ischemic renal injury and formation of renoprotective docosahexaenoic acid-derived protectin D1.
19211925	FASEB J.	2009	González-Périz A et al.	Obesity-induced insulin resistance and hepatic steatosis are alleviated by omega-3 fatty acids: a role for resolvins and protectins.
19357361	Invest. Ophthalmol. Vis. Sci.	2009	Miranda GE et al.	Sphingosine-1-phosphate is a key regulator of proliferation and differentiation in retina photoreceptors.
19050288	J. Immunol.	2008	Kasuga K et al.	Rapid appearance of resolvin precursors in inflammatory exudates: novel mechanisms in resolution.
19088251	Am. J. Physiol. Endocrinol. Metab.	2009	Banga A et al.	Adiponectin translation is increased by the PPARgamma agonists pioglitazone and omega-3 fatty acids.
19443724	Invest. Ophthalmol. Vis. Sci.	2009	Tian H et al.	Resolvins E1 and D1 in choroid-retinal endothelial cells and leukocytes: biosynthesis and mechanisms of anti-inflammatory actions.
19453514	FEMS Microbiol. Lett.	2009	Orikasa Y et al.	pfaB products determine the molecular species produced in bacterial polyunsaturated fatty acid biosynthesis.
19567784	Mol. Cancer Res.	2009	Altenburg JD and Siddiqui RA	Omega-3 polyunsaturated fatty acids down-modulate CXCR4 expression and function in MDA-MB-231 breast cancer cells.
19638488	Cancer Prev Res (Phila)	2009	Giros A et al.	Regulation of colorectal cancer cell apoptosis by the n-3 polyunsaturated fatty acids Docosahexaenoic and Eicosapentaenoic.
19433614	Am. J. Epidemiol.	2009	Arsenault LN et al.	Validity of estimated dietary eicosapentaenoic acid and docosahexaenoic acid intakes determined by interviewer-administered food frequency questionnaire among older adults with mild-to-moderate cognitive impairment or dementia.
19887546	Mol. Cancer Ther.	2009	Lim K et al.	Omega-3 polyunsaturated fatty acids inhibit hepatocellular carcinoma cell growth through blocking beta-catenin and cyclooxygenase-2.
19797230	Invest. Ophthalmol. Vis. Sci.	2010	Cortina MS et al.	Neuroprotectin D1 synthesis and corneal nerve regeneration after experimental surgery and treatment with PEDF plus DHA.
19797232	Invest. Ophthalmol. Vis. Sci.	2010	Abrahan CE et al.	Synthesis of sphingosine is essential for oxidative stress-induced apoptosis of photoreceptors.
19890019	FASEB J.	2010	Gleissman H et al.	Docosahexaenoic acid metabolome in neural tumors: identification of cytotoxic intermediates.
20624993	J. Pharmacol. Exp. Ther.	2010	Khairallah RJ et al.	Treatment with docosahexaenoic acid, but not eicosapentaenoic acid, delays Ca2+-induced mitochondria permeability transition in normal and hypertrophied myocardium.
20551373	Circ Cardiovasc Qual Outcomes	2010	Pottala JV et al.	Blood eicosapentaenoic and docosahexaenoic acids predict all-cause mortality in patients with stable coronary heart disease: the Heart and Soul study.
20097770	Am. J. Physiol. Heart Circ. Physiol.	2010	Billman GE et al.	Effects of dietary omega-3 fatty acids on ventricular function in dogs with healed myocardial infarctions: in vivo and in vitro studies.
21813701	J. Neurosci.	2011	Beck G et al.	Neuroaxonal dystrophy in calcium-independent phospholipase A2β deficiency results from insufficient remodeling and degeneration of mitochondrial and presynaptic membranes.
17962433	Invest. Ophthalmol. Vis. Sci.	2007	Bazan NG	Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.
17962470	Invest. Ophthalmol. Vis. Sci.	2007	Chucair AJ et al.	Lutein and zeaxanthin protect photoreceptors from apoptosis induced by oxidative stress: relation with docosahexaenoic acid.
17670935	Proc. Natl. Acad. Sci. U.S.A.	2007	Mukherjee PK et al.	Photoreceptor outer segment phagocytosis attenuates oxidative stress-induced apoptosis with concomitant neuroprotectin D1 synthesis.
17670936	Proc. Natl. Acad. Sci. U.S.A.	2007	Mukherjee PK et al.	Neurotrophins enhance retinal pigment epithelial cell survival through neuroprotectin D1 signaling.
18065628	Appl. Environ. Microbiol.	2008	Okuyama H et al.	Significance of antioxidative functions of eicosapentaenoic and docosahexaenoic acids in marine microorganisms.
18353804	Am. J. Epidemiol.	2008	Oken E et al.	Maternal fish intake during pregnancy, blood mercury levels, and child cognition at age 3 years in a US cohort.
16216871	J. Biol. Chem.	2005	Ariel A et al.	The docosatriene protectin D1 is produced by TH2 skewing and promotes human T cell apoptosis via lipid raft clustering.
16299163	Drug Metab. Dispos.	2006	Hirunpanich V et al.	Demonstration of docosahexaenoic acid as a bioavailability enhancer for CYP3A substrates: in vitro and in vivo evidence using cyclosporin in rats.
16424216	J. Immunol.	2006	Serhan CN et al.	Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes.
17077332	Blood	2007	Brown M et al.	Emodin and DHA potently increase arsenic trioxide interferon-alpha-induced cell death of HTLV-I-transformed cells by generation of reactive oxygen species and inhibition of Akt and AP-1.
17035384	Cancer Epidemiol. Biomarkers Prev.	2006	Kuriki K et al.	Risk of colorectal cancer is linked to erythrocyte compositions of fatty acids as biomarkers for dietary intakes of fish, fat, and fatty acids.
17053155	Clin. Chem.	2006	Cao J et al.	Incorporation and clearance of omega-3 fatty acids in erythrocyte membranes and plasma phospholipids.
17056514	J. Immunol.	2006	Duffield JS et al.	Resolvin D series and protectin D1 mitigate acute kidney injury.
17056761	FASEB J.	2006	González-Périz A et al.	Docosahexaenoic acid (DHA) blunts liver injury by conversion to protective lipid mediators: protectin D1 and 17S-hydroxy-DHA.
17182589	J. Immunol.	2007	Levy BD et al.	Protectin D1 is generated in asthma and dampens airway inflammation and hyperresponsiveness.
22013115	J. Immunol.	2011	Titos E et al.	Resolvin D1 and its precursor docosahexaenoic acid promote resolution of adipose tissue inflammation by eliciting macrophage polarization toward an M2-like phenotype.
22282329	Circulation	2012	Wu JH et al.	Association of plasma phospholipid long-chain ω-3 fatty acids with incident atrial fibrillation in older adults: the cardiovascular health study.
22332072	Adv Nutr	2011	Kalupahana NS et al.	(n-3) Fatty acids alleviate adipose tissue inflammation and insulin resistance: mechanistic insights.
22332096	Adv Nutr	2012	Swanson D et al.	Omega-3 fatty acids EPA and DHA: health benefits throughout life.
22923273	Circ Arrhythm Electrophysiol	2012	Ramadeen A et al.	Docosahexaenoic acid, but not eicosapentaenoic acid, supplementation reduces vulnerability to atrial fibrillation.
21724996	J. Immunol.	2011	Bento AF et al.	Omega-3 fatty acid-derived mediators 17(R)-hydroxy docosahexaenoic acid, aspirin-triggered resolvin D1 and resolvin D2 prevent experimental colitis in mice.
22772592	Mol. Pharmacol.	2012	Nakano M et al.	CYP4V2 in Bietti's crystalline dystrophy: ocular localization, metabolism of ω-3-polyunsaturated fatty acids, and functional deficit of the p.H331P variant.
22802419	J. Immunol.	2012	Rogerio AP et al.	Resolvin D1 and aspirin-triggered resolvin D1 promote resolution of allergic airways responses.
23504711	FASEB J.	2013	Dalli J et al.	The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype.
23103493	Am. J. Physiol. Heart Circ. Physiol.	2013	Galvao TF et al.	Marine n3 polyunsaturated fatty acids enhance resistance to mitochondrial permeability transition in heart failure but do not improve survival.
23174566	Am. J. Physiol., Cell Physiol.	2013	Larson MK et al.	Exogenous modification of platelet membranes with the omega-3 fatty acids EPA and DHA reduces platelet procoagulant activity and thrombus formation.
23702780	Invest. Ophthalmol. Vis. Sci.	2013	Cortina MS et al.	Neuroprotectin D1 restores corneal nerve integrity and function after damage from experimental surgery.
24849348	J. Neurosci.	2014	Ma QL et al.	Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.
24228198	Adv Nutr	2013	Cederholm T et al.	ω-3 fatty acids in the prevention of cognitive decline in humans.
10843708	J. Immunol.	2000	Marx N et al.	Peroxisome proliferator-activated receptor-gamma activators inhibit IFN-gamma-induced expression of the T cell-active CXC chemokines IP-10, Mig, and I-TAC in human endothelial cells.