Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
PMID | Journal | Published Date | Author | Title |
---|---|---|---|---|
12527801 | Mol. Pharmacol. | 2003 | Florio T et al. | Basic fibroblast growth factor activates endothelial nitric-oxide synthase in CHO-K1 cells via the activation of ceramide synthesis. |
12890700 | FASEB J. | 2003 | Gratzinger D et al. | Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho. |
15277330 | Circulation | 2004 | Augé N et al. | Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation. |
20674008 | Biomaterials | 2010 | Tengood JE et al. | Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis. |
21091645 | Br. J. Pharmacol. | 2011 | Sabbadini RA | Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration. |
21707492 | Anticancer Agents Med Chem | 2011 | Stevenson CE et al. | Targeting sphingosine-1-phosphate in hematologic malignancies. |
21159389 | Trends Pharmacol. Sci. | 2011 | Chi H | Sphingosine-1-phosphate and immune regulation: trafficking and beyond. |
21166920 | Microcirculation | 2011 | Markiewicz M et al. | Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells. |
21546914 | Nat. Rev. Immunol. | 2011 | Spiegel S and Milstien S | The outs and the ins of sphingosine-1-phosphate in immunity. |
18978071 | Plant Physiol. | 2009 | Michaelson LV et al. | Functional characterization of a higher plant sphingolipid Delta4-desaturase: defining the role of sphingosine and sphingosine-1-phosphate in Arabidopsis. |
19011048 | Am. J. Physiol. Heart Circ. Physiol. | 2009 | Lee JF et al. | Balance of S1P1 and S1P2 signaling regulates peripheral microvascular permeability in rat cremaster muscle vasculature. |
19158154 | FASEB J. | 2009 | Liao JJ et al. | Immunosuppressive human anti-lymphocyte autoantibodies specific for the type 1 sphingosine 1-phosphate receptor. |
19474291 | Am. J. Physiol., Cell Physiol. | 2009 | Chang CL et al. | S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells. |
19644058 | Stroke | 2009 | Wacker BK et al. | Hypoxic preconditioning-induced cerebral ischemic tolerance: role of microvascular sphingosine kinase 2. |
22095950 | J. Am. Soc. Nephrol. | 2012 | Park SW et al. | Inhibition of sphingosine 1-phosphate receptor 2 protects against renal ischemia-reperfusion injury. |
21787121 | Crit. Rev. Biochem. Mol. Biol. | 2011 | Gault CR and Obeid LM | Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy. |
17331485 | Cardiovasc. Res. | 2007 | Yang Q | Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival. |
17991617 | Prostaglandins Other Lipid Mediat. | 2007 | Lee YM et al. | A novel method to quantify sphingosine 1-phosphate by immobilized metal affinity chromatography (IMAC). |
18178864 | J. Immunol. | 2008 | Johann AM et al. | Apoptotic cell-derived sphingosine-1-phosphate promotes HuR-dependent cyclooxygenase-2 mRNA stabilization and protein expression. |
18292290 | Blood | 2008 | Kunisawa J et al. | Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells. |
18405965 | Biomaterials | 2008 | Sefcik LS et al. | Sustained release of sphingosine 1-phosphate for therapeutic arteriogenesis and bone tissue engineering. |
18408039 | Biophys. J. | 2008 | Arce FT et al. | Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin. |
18359884 | Am. J. Physiol. Lung Cell Mol. Physiol. | 2008 | Nishiuma T et al. | Inhalation of sphingosine kinase inhibitor attenuates airway inflammation in asthmatic mouse model. |
15545521 | Circulation | 2004 | Levkau B et al. | High-density lipoprotein stimulates myocardial perfusion in vivo. |
15522918 | J. Leukoc. Biol. | 2005 | Itagaki K et al. | Lysophosphatidic acid triggers calcium entry through a non-store-operated pathway in human neutrophils. |
16956968 | Am. J. Physiol., Cell Physiol. | 2007 | Leiber D et al. | Exogenous sphingosine 1-phosphate and sphingosine kinase activated by endothelin-1 induced myometrial contraction through differential mechanisms. |
17080194 | J. Clin. Invest. | 2006 | Idzko M et al. | Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function. |
17234743 | Blood | 2007 | Kunisawa J et al. | Sphingosine 1-phosphate regulates peritoneal B-cell trafficking for subsequent intestinal IgA production. |
17242282 | Circulation | 2007 | Nofer JR et al. | FTY720, a synthetic sphingosine 1 phosphate analogue, inhibits development of atherosclerosis in low-density lipoprotein receptor-deficient mice. |
18552276 | Pharmacol. Rev. | 2008 | Takabe K et al. | "Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets. |
18691012 | Curr Drug Targets | 2008 | Zeidan YH et al. | Molecular targeting of acid ceramidase: implications to cancer therapy. |
18638568 | Biochim. Biophys. Acta | 2008 | Lynch KR and Macdonald TL | Sphingosine 1-phosphate chemical biology. |
18787560 | Nat. Rev. Immunol. | 2008 | Rivera J et al. | The alliance of sphingosine-1-phosphate and its receptors in immunity. |
18751921 | Subcell. Biochem. | 2008 | Saddoughi SA et al. | Roles of bioactive sphingolipids in cancer biology and therapeutics. |
18815359 | FASEB J. | 2009 | Snider AJ et al. | A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis. |
22533672 | Biochem. J. | 2012 | Lynch KR | Building a better sphingosine kinase-1 inhibitor. |
22016563 | Mol. Endocrinol. | 2011 | El-Shewy HM et al. | Phospholipase C and protein kinase C-β 2 mediate insulin-like growth factor II-dependent sphingosine kinase 1 activation. |
22326262 | Biochem. Biophys. Res. Commun. | 2012 | Takeshita H et al. | Sphingosine 1-phosphate (S1P)/S1P receptor 1 signaling regulates receptor activator of NF-κB ligand (RANKL) expression in rheumatoid arthritis. |
22664872 | J. Immunol. | 2012 | Nijnik A et al. | The role of sphingosine-1-phosphate transporter Spns2 in immune system function. |
23326540 | PLoS ONE | 2013 | Yasuo M et al. | Fenretinide causes emphysema, which is prevented by sphingosine 1-phoshate. |
23307289 | Mol. Cells | 2013 | Kim YD et al. | Effects of sphingosine-1-phosphate on pacemaker activity of interstitial cells of Cajal from mouse small intestine. |
23150617 | Invest. Ophthalmol. Vis. Sci. | 2012 | Qiao Y et al. | Sphingosine 1-phosphate elicits proinflammatory responses in ARPE-19 cells. |
24448739 | Circ Cardiovasc Genet | 2014 | Moxon JV et al. | Comparison of the serum lipidome in patients with abdominal aortic aneurysm and peripheral artery disease. |
20463083 | J. Virol. | 2010 | Gorbunova E et al. | Pathogenic hantaviruses Andes virus and Hantaan virus induce adherens junction disassembly by directing vascular endothelial cadherin internalization in human endothelial cells. |