trichostatin A

Trichostatin is a lipid of Polyketides (PK) class. Trichostatin is associated with abnormalities such as Dentatorubral-Pallidoluysian Atrophy, PARAGANGLIOMAS 3, abnormal fragmented structure, Disintegration (morphologic abnormality) and Hyperostosis, Diffuse Idiopathic Skeletal. The involved functions are known as Acetylation, Cell Differentiation process, histone modification, Gene Silencing and Transcriptional Activation. Trichostatin often locates in CD41a, Hematopoietic System, Chromatin Structure, Blood and Endothelium. The associated genes with Trichostatin are SPI1 gene, CELL Gene, Chromatin, CXCR4 gene and DNMT1 gene. The related lipids are Butyrates, Promega, butyrate, Lipopolysaccharides and Steroids. The related experimental models are Knock-out, Mouse Model, Xenograft Model and Cancer Model.

References related to pathways published in Others

PMID	Journal	Published Date	Author	Title
12692061	Gut	2003	Schauber J et al.	Expression of the cathelicidin LL-37 is modulated by short chain fatty acids in colonocytes: relevance of signalling pathways.
15269190	Drug Metab. Dispos.	2004	Sanderson L et al.	Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice.
19805354	Proc. Natl. Acad. Sci. U.S.A.	2009	Gibbs A et al.	Sulforaphane destabilizes the androgen receptor in prostate cancer cells by inactivating histone deacetylase 6.
21771882	J. Cell. Sci.	2011	Watanabe Y and Tanaka M	p62/SQSTM1 in autophagic clearance of a non-ubiquitylated substrate.
18381445	Cancer Res.	2008	Lin YC et al.	Statins increase p21 through inhibition of histone deacetylase activity and release of promoter-associated HDAC1/2.
17220171	Hum. Mol. Genet.	2007	Ting CH et al.	Stat5 constitutive activation rescues defects in spinal muscular atrophy.
22693257	J. Lipid Res.	2012	Nunes MJ et al.	Okadaic acid inhibits the trichostatin A-mediated increase of human CYP46A1 neuronal expression in a ERK1/2-Sp3-dependent pathway.