20-HETE
20-hete is a lipid of Fatty Acyls (FA) class. 20-hete is associated with abnormalities such as Cyst, Kidney Diseases, Kidney Failure, Chronic, Cystic Kidney Diseases and Simple renal cyst. The involved functions are known as Phosphorylation, inhibitors, Hypertrophy, Epithelial Cell Proliferation and Anabolism. 20-hete often locates in Mouse Kidney, Microsomes, Tissue membrane, Body tissue and Cytoplasmic matrix. The associated genes with 20-HETE are CYP4F3 gene, PKHD1 gene, Transgenes, P4HTM gene and CYP2E1 gene. The related lipids are Promega, enterodiol, Fatty Acids, hexanoic acid and U 73343. The related experimental models are Mouse Model, Knock-out, Streptozotocin Diabetes, Transgenic Model and Rodent Model.
References related to pathways published in Others
| PMID | Journal | Published Date | Author | Title |
|---|---|---|---|---|
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| 19570883 | Am. J. Physiol. Renal Physiol. | 2009 | Akbulut T et al. | 20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism. |
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| 17303679 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | 2007 | Yu M et al. | Effects of 20-HETE on Na+ transport and Na+ -K+ -ATPase activity in the thick ascending loop of Henle. |
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| 16675634 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | 2006 | Joly E et al. | Increased renal vascular reactivity to ANG II after unilateral nephrectomy in the rat involves 20-HETE. |
| 16679377 | Am. J. Physiol. Lung Cell Mol. Physiol. | 2006 | Chen Y et al. | Mechanisms of activation of eNOS by 20-HETE and VEGF in bovine pulmonary artery endothelial cells. |
| 16679379 | Am. J. Physiol. Lung Cell Mol. Physiol. | 2006 | Jacobs ER et al. | VEGF-induced relaxation of pulmonary arteries is mediated by endothelial cytochrome P-450 hydroxylase. |
| 16601220 | Stroke | 2006 | Omura T et al. | Effect of a new inhibitor of the synthesis of 20-HETE on cerebral ischemia reperfusion injury. |
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| 22798501 | Cancer Genomics Proteomics | 2012 Jul-Aug | Alexanian A et al. | 20-HETE-producing enzymes are up-regulated in human cancers. |
| 23641057 | J. Am. Soc. Nephrol. | 2013 | Wu CC et al. | Androgen-sensitive hypertension associates with upregulated vascular CYP4A12-20-HETE synthase. |
| 23392684 | J. Neurosci. | 2013 | Fordsmann JC et al. | Increased 20-HETE synthesis explains reduced cerebral blood flow but not impaired neurovascular coupling after cortical spreading depression in rat cerebral cortex. |
| 23966667 | J. Lipid Res. | 2013 | Van Bogaert I et al. | Preparation of 20-HETE using multifunctional enzyme type 2-negative Starmerella bombicola. |