Isopentenyl pyrophosphate is a lipid of Prenol Lipids (PR) class. Isopentenyl pyrophosphate is associated with abnormalities such as Tuberculosis, NAVAJO NEUROHEPATOPATHY and Cryptosporidiosis. The involved functions are known as Signal, Anabolism, T-Cell Activation, T-Cell Proliferation and isoprenoid biosynthetic process. Isopentenyl pyrophosphate often locates in Protoplasm, Host Cell, soluble, Plastids and Cell surface. The associated genes with Isopentenyl pyrophosphate are oxytocin, 1-desamino-(O-Et-Tyr)(2)-, HLA-E gene, RAP1A gene, Gene Family and Orthologous Gene. The related lipids are Steroids, Sterols and isopentenol.
|11042147||Genome Res.||2000||Smit A and Mushegian A||Biosynthesis of isoprenoids via mevalonate in Archaea: the lost pathway.|
|21646473||Cancer Res.||2011||Benzaïd I et al.||High phosphoantigen levels in bisphosphonate-treated human breast tumors promote Vgamma9Vdelta2 T-cell chemotaxis and cytotoxicity in vivo.|
|19656068||J. Infect. Dis.||2009||Qin G et al.||Phosphoantigen-expanded human gammadelta T cells display potent cytotoxicity against monocyte-derived macrophages infected with human and avian influenza viruses.|
|19875454||J. Biol. Chem.||2010||Mitrofan LM et al.||Lysosomal-mitochondrial axis in zoledronic acid-induced apoptosis in human follicular lymphoma cells.|
|17693564||Appl. Environ. Microbiol.||2007||Withers ST et al.||Identification of isopentenol biosynthetic genes from Bacillus subtilis by a screening method based on isoprenoid precursor toxicity.|
|16698791||J. Biol. Chem.||2006||Kavanagh KL et al.||The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding.|
|16179378||Blood||2006||Thompson K et al.||Alkylamines cause Vgamma9Vdelta2 T-cell activation and proliferation by inhibiting the mevalonate pathway.|