Gossypol

Gossypol is a lipid of Prenol Lipids (PR) class. Gossypol is associated with abnormalities such as Paralytic Ileus, PARKINSON DISEASE, LATE-ONSET, Fibrillation, Hepatic necrosis and Lymphopenia. The involved functions are known as Atrophic, Ulcer, Necrosis, Apoptosis and antagonists. Gossypol often locates in Mucous Membrane, Epithelium, Blood, Microsomes, Liver and Autophagic vacuole. The associated genes with Gossypol are BCL2A1 gene, BCL2 gene, Transgenes, IGH@ gene cluster and Bax protein (53-86). The related lipids are Promega, proteoliposomes, Phosphatidylserines and Liposomes. The related experimental models are Transgenic Model and Xenograft Model.

References related to pathways published in Others

PMID	Journal	Published Date	Author	Title
15621416	FEMS Microbiol. Lett.	2005	Weissenmayer B et al.	The calcineurin inhibitor gossypol impairs growth, cell signalling and development in Dictyostelium discoideum.
15849309	Plant Physiol.	2005	Townsend BJ et al.	Antisense suppression of a (+)-delta-cadinene synthase gene in cotton prevents the induction of this defense response gene during bacterial blight infection but not its constitutive expression.
16935937	FASEB J.	2006	Lei X et al.	Gossypol induces Bax/Bak-independent activation of apoptosis and cytochrome c release via a conformational change in Bcl-2.
18566329	Blood	2008	Balakrishnan K et al.	Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells.
22525702	Cancer Res.	2012	Mazumder S et al.	Mcl-1 Phosphorylation defines ABT-737 resistance that can be overcome by increased NOXA expression in leukemic B cells.