Sphingosine 1-phosphate

Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.

References related to pathways published in Others

PMID	Journal	Published Date	Author	Title
10080537	J. Leukoc. Biol.	1999	Spiegel S	Sphingosine 1-phosphate: a prototype of a new class of second messengers.
10537322	Cancer Res.	1999	Goetzl EJ et al.	Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer.
10471775	FEBS Lett.	1999	Meacci E et al.	Receptor-mediated activation of phospholipase D by sphingosine 1-phosphate in skeletal muscle C2C12 cells. A role for protein kinase C.
9931312	Biochem. J.	1999	Hung WC et al.	Activation of caspase-3-like proteases in apoptosis induced by sphingosine and other long-chain bases in Hep3B hepatoma cells.
9821862	Acta Biochim. Pol.	1998	Igarashi Y and Yatomi Y	Sphingosine 1-phosphate is a blood constituent released from activated platelets, possibly playing a variety of physiological and pathophysiological roles.
11168352	Eur. J. Biochem.	2001	Radin NS	Killing cancer cells by poly-drug elevation of ceramide levels: a hypothesis whose time has come?
11583630	Mol. Cell	2001	Lee MJ et al.	Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis.
11557732	Circ. Res.	2001	Erl W and Siess W	Sphingosine-1-phosphate and the leading Edg-1 of vascular smooth muscle cells.
11544274	J. Clin. Invest.	2001	Garcia JG et al.	Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement.
11923495	Science	2002	Mandala S et al.	Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists.
11313900	Oncogene	2001	Kranenburg O and Moolenaar WH	Ras-MAP kinase signaling by lysophosphatidic acid and other G protein-coupled receptor agonists.
11418470	Blood	2001	Olorundare OE et al.	Assembly of a fibronectin matrix by adherent platelets stimulated by lysophosphatidic acid and other agonists.
12149127	Biochem. J.	2002	Wang L et al.	Involvement of phospholipases D1 and D2 in sphingosine 1-phosphate-induced ERK (extracellular-signal-regulated kinase) activation and interleukin-8 secretion in human bronchial epithelial cells.
12648236	J. Invest. Dermatol.	2003	Vogler R et al.	Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing.
13679519	Mol. Biol. Cell	2004	Deretic D et al.	Phosphoinositides, ezrin/moesin, and rac1 regulate fusion of rhodopsin transport carriers in retinal photoreceptors.
12665551	J. Cell. Sci.	2003	Kim DS et al.	Sphingosine-1-phosphate decreases melanin synthesis via sustained ERK activation and subsequent MITF degradation.
12667959	Cardiovasc. Res.	2003	Ohmori T et al.	Sphingosine 1-phosphate induces contraction of coronary artery smooth muscle cells via S1P2.
12730100	Blood	2003	Takeya H et al.	Synergistic effect of sphingosine 1-phosphate on thrombin-induced tissue factor expression in endothelial cells.
12527801	Mol. Pharmacol.	2003	Florio T et al.	Basic fibroblast growth factor activates endothelial nitric-oxide synthase in CHO-K1 cells via the activation of ceramide synthesis.
12615978	J. Cell. Sci.	2003	Deroanne C et al.	EphrinA1 inactivates integrin-mediated vascular smooth muscle cell spreading via the Rac/PAK pathway.
12618517	J. Clin. Invest.	2003	Honig SM et al.	FTY720 stimulates multidrug transporter- and cysteinyl leukotriene-dependent T cell chemotaxis to lymph nodes.
12482824	Arterioscler. Thromb. Vasc. Biol.	2002	Auge N et al.	Oxidized LDL-induced smooth muscle cell proliferation involves the EGF receptor/PI-3 kinase/Akt and the sphingolipid signaling pathways.
12856002	EMBO Rep.	2003	Burnett C and Howard K	Fly and mammalian lipid phosphate phosphatase isoforms differ in activity both in vitro and in vivo.
12882914	Diabetes	2003	Laychock SG et al.	Endothelial differentiation gene receptors in pancreatic islets and INS-1 cells.
10555146	Cell	1999	Lee MJ et al.	Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate.
10567700	FEBS Lett.	1999	Meyer zu Heringdorf D et al.	Role of sphingosine kinase in Ca(2+) signalling by epidermal growth factor receptor.
11032855	J. Clin. Invest.	2000	Liu Y et al.	Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation.
10878250	FEBS Lett.	2000	Spiegel S and Milstien S	Sphingosine-1-phosphate: signaling inside and out.
10915638	Am. J. Physiol. Gastrointest. Liver Physiol.	2000	Ikeda H et al.	Biological activities of novel lipid mediator sphingosine 1-phosphate in rat hepatic stellate cells.
10626811	Cancer Res.	1999	Wang F et al.	Sphingosine-1-phosphate inhibits motility of human breast cancer cells independently of cell surface receptors.
9826186	Eur. J. Biochem.	1998	Guo C et al.	Differential stimulation of proline-rich tyrosine kinase 2 and mitogen-activated protein kinase by sphingosine 1-phosphate.
9826677	Proc. Natl. Acad. Sci. U.S.A.	1998	Xia P et al.	Tumor necrosis factor-alpha induces adhesion molecule expression through the sphingosine kinase pathway.
11788469	Arterioscler. Thromb. Vasc. Biol.	2002	Rikitake Y et al.	Involvement of endothelial nitric oxide in sphingosine-1-phosphate-induced angiogenesis.
14567755	Biochem. J.	2004	Kelley GG et al.	Hormonal regulation of phospholipase Cepsilon through distinct and overlapping pathways involving G12 and Ras family G-proteins.
14573770	Mol. Pharmacol.	2003	Sorensen SD et al.	Common signaling pathways link activation of murine PAR-1, LPA, and S1P receptors to proliferation of astrocytes.
14564080	J. Atheroscler. Thromb.	2003	Ozaki H et al.	Sphingosine-1-phosphate signaling in endothelial activation.
15317688	Biol. Reprod.	2004	Roth Z and Hansen PJ	Sphingosine 1-phosphate protects bovine oocytes from heat shock during maturation.
15326035	Br. J. Pharmacol.	2004	Hemmings DG et al.	Sphingosine 1-phosphate-induced vasoconstriction is elevated in mesenteric resistance arteries from aged female rats.
15273282	Proc. Natl. Acad. Sci. U.S.A.	2004	Matsushita K et al.	Sphingosine 1-phosphate activates Weibel-Palade body exocytosis.
15277330	Circulation	2004	Augé N et al.	Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.
15213242	J. Biochem.	2004	Yokoo E et al.	Sphingosine 1-phosphate inhibits migration of RBL-2H3 cells via S1P2: cross-talk between platelets and mast cells.
15258896	J. Cell. Biochem.	2004	Goetzl EJ et al.	Sphingosine 1-phosphate and its G protein-coupled receptors constitute a multifunctional immunoregulatory system.
15265887	J. Immunol.	2004	Melendez AJ and Ibrahim FB	Antisense knockdown of sphingosine kinase 1 in human macrophages inhibits C5a receptor-dependent signal transduction, Ca2+ signals, enzyme release, cytokine production, and chemotaxis.
15059942	Circ. Res.	2004	Saba JD and Hla T	Point-counterpoint of sphingosine 1-phosphate metabolism.
15143482	J. Infect. Dis.	2004	Garg SK et al.	Sphingosine 1-phosphate induces antimicrobial activity both in vitro and in vivo.
14747617	J. Pharmacol. Exp. Ther.	2004	Forrest M et al.	Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes.
14688232	J. Biochem.	2003	Kohno T and Igarashi Y	Truncation of the N-terminal ectodomain has implications in the N-glycosylation and transport to the cell surface of Edg-1/S1P1 receptor.
14608042	J. Nutr.	2003	Castillo SS and Teegarden D	Sphingosine-1-phosphate inhibition of apoptosis requires mitogen-activated protein kinase phosphatase-1 in mouse fibroblast C3H10T 1/2 cells.
15451787	Circulation	2004	Jin ZQ et al.	Sphingosine kinase activation mediates ischemic preconditioning in murine heart.
20696404	Structure	2010	Bourquin F et al.	Structure and function of sphingosine-1-phosphate lyase, a key enzyme of sphingolipid metabolism.
20671234	Circ. Res.	2010	Hoefer J et al.	Sphingosine-1-phosphate-dependent activation of p38 MAPK maintains elevated peripheral resistance in heart failure through increased myogenic vasoconstriction.
20674008	Biomaterials	2010	Tengood JE et al.	Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.
21075134	Adv. Enzyme Regul.	2011	Siow DL et al.	Sphingosine kinase localization in the control of sphingolipid metabolism.
21091645	Br. J. Pharmacol.	2011	Sabbadini RA	Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.
21707492	Anticancer Agents Med Chem	2011	Stevenson CE et al.	Targeting sphingosine-1-phosphate in hematologic malignancies.
21713655	Adv. Exp. Med. Biol.	2011	Olivera A and Rivera J	An emerging role for the lipid mediator sphingosine-1-phosphate in mast cell effector function and allergic disease.
21685263	Am. J. Physiol. Heart Circ. Physiol.	2011	Vessey DA et al.	P2X7 receptor agonists pre- and postcondition the heart against ischemia-reperfusion injury by opening pannexin-1/P2X₇ channels.
21629665	PLoS ONE	2011	Donati C et al.	Sphingosine 1-phosphate induces differentiation of mesoangioblasts towards smooth muscle. A role for GATA6.
21421853	J. Immunol.	2011	Ocaña-Morgner C et al.	Sphingosine 1-phosphate-induced motility and endocytosis of dendritic cells is regulated by SWAP-70 through RhoA.
21412255	J. Invest. Dermatol.	2011	Lamana A et al.	CD69 modulates sphingosine-1-phosphate-induced migration of skin dendritic cells.
21383307	Hypertension	2011	Yogi A et al.	Sphingosine-1-phosphate-induced inflammation involves receptor tyrosine kinase transactivation in vascular cells: upregulation in hypertension.
21478479	Am. J. Physiol. Renal Physiol.	2011	Zhu Q et al.	A novel lipid natriuretic factor in the renal medulla: sphingosine-1-phosphate.
21511695	Am. J. Physiol. Renal Physiol.	2011	Jackson EK	Role of sphingosine-1-phosphate in the renal medulla.
20978351	J. Clin. Invest.	2010	Wang F et al.	Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice.
20935520	Autophagy	2010	Zhang N et al.	FTY720 induces necrotic cell death and autophagy in ovarian cancer cells: a protective role of autophagy.
21159389	Trends Pharmacol. Sci.	2011	Chi H	Sphingosine-1-phosphate and immune regulation: trafficking and beyond.
21166920	Microcirculation	2011	Markiewicz M et al.	Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.
21084214	Cytokine Growth Factor Rev.	2010	Hirahara K et al.	Signal transduction pathways and transcriptional regulation in Th17 cell differentiation.
20811395	J. Invest. Dermatol.	2011	Bäumer W et al.	Decreased concentration and enhanced metabolism of sphingosine-1-phosphate in lesional skin of dogs with atopic dermatitis: disturbed sphingosine-1-phosphate homeostasis in atopic dermatitis.
21602610	Pharmacol Rep	2011	Chiba Y et al.	Sphingosine-1-phosphate augments agonist-mediated contraction in the bronchial smooth muscles of mice.
21546914	Nat. Rev. Immunol.	2011	Spiegel S and Milstien S	The outs and the ins of sphingosine-1-phosphate in immunity.
21559342	PLoS ONE	2011	Soleimani R et al.	Enhancement of neoangiogenesis and follicle survival by sphingosine-1-phosphate in human ovarian tissue xenotransplants.
19228708	Cardiovasc. Res.	2009	Gellings Lowe N et al.	Sphingosine-1-phosphate and sphingosine kinase are critical for transforming growth factor-beta-stimulated collagen production by cardiac fibroblasts.
19233865	Cardiovasc. Res.	2009	Igarashi J and Michel T	Sphingosine-1-phosphate and modulation of vascular tone.
19204730	Nature	2009	Ishii M et al.	Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis.
19194476	J. Invest. Dermatol.	2009	Reines I et al.	Topical application of sphingosine-1-phosphate and FTY720 attenuate allergic contact dermatitis reaction through inhibition of dendritic cell migration.
18988873	Blood	2008	Severinson E	WASp stings mature lymphocytes.
18805898	Am. J. Physiol. Heart Circ. Physiol.	2008	Kang H et al.	Fluid shear stress modulates endothelial cell invasion into three-dimensional collagen matrices.
18978071	Plant Physiol.	2009	Michaelson LV et al.	Functional characterization of a higher plant sphingolipid Delta4-desaturase: defining the role of sphingosine and sphingosine-1-phosphate in Arabidopsis.
18981156	J. Immunol.	2008	Kimura T et al.	Induction of scavenger receptor class B type I is critical for simvastatin enhancement of high-density lipoprotein-induced anti-inflammatory actions in endothelial cells.
19325137	Arterioscler. Thromb. Vasc. Biol.	2009	Hayashi H et al.	FHL-2 suppresses VEGF-induced phosphatidylinositol 3-kinase/Akt activation via interaction with sphingosine kinase-1.
19289077	Dev. Cell	2009	Boyce BF	Sphingosine-1 phosphate: a new player in osteoimmunology.
19372554	Mol. Cancer Ther.	2009	Guillermet-Guibert J et al.	Targeting the sphingolipid metabolism to defeat pancreatic cancer cell resistance to the chemotherapeutic gemcitabine drug.
19348755	Biophys. J.	2009	Sasaki H et al.	pH dependence of sphingosine aggregation.
19351713	J. Cell. Sci.	2009	Formigli L et al.	Regulation of transient receptor potential canonical channel 1 (TRPC1) by sphingosine 1-phosphate in C2C12 myoblasts and its relevance for a role of mechanotransduction in skeletal muscle differentiation.
19218288	Cardiovasc. Res.	2009	Choi SK et al.	Comparison of contractile mechanisms of sphingosylphosphorylcholine and sphingosine-1-phosphate in rabbit coronary artery.
19755153	Cell. Signal.	2009	Zhao J et al.	Phosphotyrosine protein dynamics in cell membrane rafts of sphingosine-1-phosphate-stimulated human endothelium: role in barrier enhancement.
19776367	J. Neurophysiol.	2009	Crousillac S et al.	Sphingosine-1-phosphate elicits receptor-dependent calcium signaling in retinal amacrine cells.
19700468	Cardiovasc. Res.	2010	Frias MA et al.	Native and reconstituted HDL protect cardiomyocytes from doxorubicin-induced apoptosis.
19062281	Curr. Biol.	2008	Osborne N et al.	The spinster homolog, two of hearts, is required for sphingosine 1-phosphate signaling in zebrafish.
19066402	J. Lipid Res.	2009	Brindley DN and Pilquil C	Lipid phosphate phosphatases and signaling.
19011048	Am. J. Physiol. Heart Circ. Physiol.	2009	Lee JF et al.	Balance of S1P1 and S1P2 signaling regulates peripheral microvascular permeability in rat cremaster muscle vasculature.
19017750	Cardiovasc. Res.	2009	Karliner JS	Sphingosine kinase regulation and cardioprotection.
19017978	J. Immunol.	2008	Bansal G et al.	RGS13 controls g protein-coupled receptor-evoked responses of human mast cells.
19017993	J. Immunol.	2008	Lai WQ et al.	Anti-inflammatory effects of sphingosine kinase modulation in inflammatory arthritis.
19147534	Mol. Cancer Res.	2009	Young N et al.	Sphingosine-1-phosphate regulates glioblastoma cell invasiveness through the urokinase plasminogen activator system and CCN1/Cyr61.
19131156	Cancer Lett.	2009	Li MH et al.	S1P/S1P1 signaling stimulates cell migration and invasion in Wilms tumor.
19139083	Blood	2009	Gérard A et al.	The Rac activator Tiam1 controls efficient T-cell trafficking and route of transendothelial migration.
19075223	Proc. Natl. Acad. Sci. U.S.A.	2008	Pederson L et al.	Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate.
19081473	Surgery	2009	Roztocil E et al.	Mechanisms of sphingosine-1-phosphate-induced akt-dependent smooth muscle cell migration.
19151362	Cardiovasc. Res.	2009	Frias MA et al.	Native and reconstituted HDL activate Stat3 in ventricular cardiomyocytes via ERK1/2: role of sphingosine-1-phosphate.
19112163	Arterioscler. Thromb. Vasc. Biol.	2009	Jang C et al.	Angiopoietin-2 exocytosis is stimulated by sphingosine-1-phosphate in human blood and lymphatic endothelial cells.
19446953	Cancer Lett.	2009	Li X et al.	Fenretinide inhibits myeloma cell growth, osteoclastogenesis and osteoclast viability.
19644058	Stroke	2009	Wacker BK et al.	Hypoxic preconditioning-induced cerebral ischemic tolerance: role of microvascular sphingosine kinase 2.
19648253	Am. J. Physiol. Heart Circ. Physiol.	2009	Vessey DA et al.	Sphingosine 1-phosphate is an important endogenous cardioprotectant released by ischemic pre- and postconditioning.
19607945	Acta Biomater	2010	Scott EA et al.	Modular scaffolds assembled around living cells using poly(ethylene glycol) microspheres with macroporation via a non-cytotoxic porogen.
19383898	Cancer Res.	2009	Ader I et al.	When the sphingosine kinase 1/sphingosine 1-phosphate pathway meets hypoxia signaling: new targets for cancer therapy.
20201063	Stem Cells	2010	Lee H et al.	Bone marrow-derived mesenchymal stem cells prevent the loss of Niemann-Pick type C mouse Purkinje neurons by correcting sphingolipid metabolism and increasing sphingosine-1-phosphate.
20397263	World J. Gastroenterol.	2010	Hu WM et al.	Effect of S1P5 on proliferation and migration of human esophageal cancer cells.
20386061	J. Lipid Res.	2010	Siow DL et al.	Intracellular localization of sphingosine kinase 1 alters access to substrate pools but does not affect the degradative fate of sphingosine-1-phosphate.
20220090	J. Immunol.	2010	Sensken SC et al.	Redistribution of sphingosine 1-phosphate by sphingosine kinase 2 contributes to lymphopenia.
19815502	Proc. Natl. Acad. Sci. U.S.A.	2009	Wojciak JM et al.	The crystal structure of sphingosine-1-phosphate in complex with a Fab fragment reveals metal bridging of an antibody and its antigen.
20458145	J. Clin. Invest.	2010	Cao C et al.	The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b.
20431071	Arterioscler. Thromb. Vasc. Biol.	2010	Yoshida T et al.	Therapeutic angiogenesis by implantation of a capillary structure constituted of human adipose tissue microvascular endothelial cells.
20584786	J Mol Cell Biol	2010	He X et al.	Sphingosine-1-phosphate mediates proliferation maintaining the multipotency of human adult bone marrow and adipose tissue-derived stem cells.
20516217	Mol. Cell. Biol.	2010	Long JS et al.	Sphingosine kinase 1 induces tolerance to human epidermal growth factor receptor 2 and prevents formation of a migratory phenotype in response to sphingosine 1-phosphate in estrogen receptor-positive breast cancer cells.
20522601	J. Lipid Res.	2010	Lee MH et al.	HDL3, but not HDL2, stimulates plasminogen activator inhibitor-1 release from adipocytes: the role of sphingosine-1-phosphate.
20498849	PLoS ONE	2010	Prakash H et al.	Sphingosine kinase-1 (SphK-1) regulates Mycobacterium smegmatis infection in macrophages.
20197547	Blood	2010	Weigert A et al.	Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells.
20097776	Mol. Pharmacol.	2010	Murakami A et al.	Sphingosine 1-phosphate (S1P) regulates vascular contraction via S1P3 receptor: investigation based on a new S1P3 receptor antagonist.
20080123	Prog. Biophys. Mol. Biol.	2010	Egom EE et al.	Cardioprotection in ischemia/reperfusion injury: spotlight on sphingosine-1-phosphate and bradykinin signalling.
17623044	J. Neurochem.	2007	Blondeau N et al.	Distribution of sphingosine kinase activity and mRNA in rodent brain.
20844107	J. Neurophysiol.	2010	Chi XX and Nicol GD	The sphingosine 1-phosphate receptor, S1PR₁, plays a prominent but not exclusive role in enhancing the excitability of sensory neurons.
21309759	Br. J. Pharmacol.	2011	Schuchardt M et al.	Pharmacological relevance and potential of sphingosine 1-phosphate in the vascular system.
21360199	Mol. Cells	2011	Ishii T et al.	The role of sphingosine 1-phosphate in migration of osteoclast precursors; an application of intravital two-photon microscopy.
21787121	Crit. Rev. Biochem. Mol. Biol.	2011	Gault CR and Obeid LM	Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.
18541717	Blood	2008	Yoon CM et al.	Sphingosine-1-phosphate promotes lymphangiogenesis by stimulating S1P1/Gi/PLC/Ca2+ signaling pathways.
22287614	Am. J. Physiol. Lung Cell Mol. Physiol.	2012	Karmouty-Quintana H et al.	Treatment with a sphingosine-1-phosphate analog inhibits airway remodeling following repeated allergen exposure.
17898040	Am. J. Physiol. Renal Physiol.	2007	Kim M et al.	Isoflurane mediates protection from renal ischemia-reperfusion injury via sphingosine kinase and sphingosine-1-phosphate-dependent pathways.
17978043	J. Neurosci.	2007	Braun A et al.	Paucity of pericytes in germinal matrix vasculature of premature infants.
17331485	Cardiovasc. Res.	2007	Yang Q	Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.
17337593	Am. J. Physiol. Heart Circ. Physiol.	2007	Landeen LK et al.	Sphingosine-1-phosphate receptor expression in cardiac fibroblasts is modulated by in vitro culture conditions.
17257496	Cell. Mol. Immunol.	2006	Matsuyuki H et al.	Involvement of sphingosine 1-phosphate (S1P) receptor type 1 and type 4 in migratory response of mouse T cells toward S1P.
17307797	Int. Immunol.	2007	Jung ID et al.	Sphingosine kinase inhibitor suppresses a Th1 polarization via the inhibition of immunostimulatory activity in murine bone marrow-derived dendritic cells.
17308123	Cancer Res.	2007	Bonnaud S et al.	Sphingosine-1-phosphate protects proliferating endothelial cells from ceramide-induced apoptosis but not from DNA damage-induced mitotic death.
17391120	Am. J. Transplant.	2007	Okazaki M et al.	Sphingosine 1-phosphate inhibits ischemia reperfusion injury following experimental lung transplantation.
17283058	Mol. Cell. Biol.	2007	Tellier E et al.	Role for furin in tumor necrosis factor alpha-induced activation of the matrix metalloproteinase/sphingolipid mitogenic pathway.
17287522	J. Neurosci.	2007	Herr DR et al.	Sphingosine 1-phosphate (S1P) signaling is required for maintenance of hair cells mainly via activation of S1P2.
17541067	Mol. Cancer Res.	2007	Langlois S et al.	Membrane-type 1 matrix metalloproteinase stimulates cell migration through epidermal growth factor receptor transactivation.
17569880	Arterioscler. Thromb. Vasc. Biol.	2007	Kontush A et al.	Preferential sphingosine-1-phosphate enrichment and sphingomyelin depletion are key features of small dense HDL3 particles: relevance to antiapoptotic and antioxidative activities.
17409372	Biol. Reprod.	2007	Hudson NK et al.	Modulation of human arterial tone during pregnancy: the effect of the bioactive metabolite sphingosine-1-phosphate.
17626797	J. Pharmacol. Exp. Ther.	2007	Itagaki K et al.	Sphingosine 1-phosphate has dual functions in the regulation of endothelial cell permeability and Ca2+ metabolism.
17619081	Cancer Lett.	2007	Karahatay S et al.	Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis.
17320845	Cardiovasc. Res.	2007	Tao R et al.	Deletion of the sphingosine kinase-1 gene influences cell fate during hypoxia and glucose deprivation in adult mouse cardiomyocytes.
17325039	Mol. Cell. Biol.	2007	Kajimoto T et al.	Involvement of sphingosine-1-phosphate in glutamate secretion in hippocampal neurons.
17652460	Mol. Biol. Cell	2007	Weigert A et al.	Tumor cell apoptosis polarizes macrophages role of sphingosine-1-phosphate.
18026125	Br. J. Pharmacol.	2008	Salomone S et al.	Analysis of sphingosine 1-phosphate receptors involved in constriction of isolated cerebral arteries with receptor null mice and pharmacological tools.
17991617	Prostaglandins Other Lipid Mediat.	2007	Lee YM et al.	A novel method to quantify sphingosine 1-phosphate by immobilized metal affinity chromatography (IMAC).
18178871	Blood	2008	Oskeritzian CA et al.	Distinct roles of sphingosine kinases 1 and 2 in human mast-cell functions.
18203850	Am. J. Physiol. Heart Circ. Physiol.	2008	Patschan S et al.	Lipid mediators of autophagy in stress-induced premature senescence of endothelial cells.
18157950	Biochim. Biophys. Acta	2008	Brunati AM et al.	Cross-talk between PDGF and S1P signalling elucidates the inhibitory effect and potential antifibrotic action of the immunomodulator FTY720 in activated HSC-cultures.
18197698	Anal. Chem.	2008	Lee KJ et al.	Determination of sphingosine kinase activity for cellular signaling studies.
18216042	Hum. Reprod.	2008	Onions VJ et al.	Ovarian tissue viability following whole ovine ovary cryopreservation: assessing the effects of sphingosine-1-phosphate inclusion.
17825823	FEBS Lett.	2007	Tani M et al.	Sphingosine 1-phosphate (S1P) inhibits monocyte-endothelial cell interaction by regulating of RhoA activity.
17827231	Biophys. J.	2008	Wacker BK et al.	Endothelial cell migration on RGD-peptide-containing PEG hydrogels in the presence of sphingosine 1-phosphate.
18292290	Blood	2008	Kunisawa J et al.	Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.
18267120	FEBS Lett.	2008	Fortier S et al.	Silencing of the MT1-MMP/ G6PT axis suppresses calcium mobilization by sphingosine-1-phosphate in glioblastoma cells.
18323526	Circ. Res.	2008	Hughes JE et al.	Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.
18199826	Blood	2008	Li X et al.	Basal and angiopoietin-1-mediated endothelial permeability is regulated by sphingosine kinase-1.
18424450	Hum. Mol. Genet.	2008	Wu YP et al.	Sphingosine kinase 1/S1P receptor signaling axis controls glial proliferation in mice with Sandhoff disease.
18426913	Mol. Cell. Biol.	2008	Miller AV et al.	Sphingosine kinases and sphingosine-1-phosphate are critical for transforming growth factor beta-induced extracellular signal-regulated kinase 1 and 2 activation and promotion of migration and invasion of esophageal cancer cells.
18405965	Biomaterials	2008	Sefcik LS et al.	Sustained release of sphingosine 1-phosphate for therapeutic arteriogenesis and bone tissue engineering.
18408039	Biophys. J.	2008	Arce FT et al.	Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.
18381082	Biochim. Biophys. Acta	2008	Goetzl EJ et al.	Regulation of the roles of sphingosine 1-phosphate and its type 1 G protein-coupled receptor in T cell immunity and autoimmunity.
18387885	J. Lipid Res.	2008	Lebman DA and Spiegel S	Cross-talk at the crossroads of sphingosine-1-phosphate, growth factors, and cytokine signaling.
18359884	Am. J. Physiol. Lung Cell Mol. Physiol.	2008	Nishiuma T et al.	Inhalation of sphingosine kinase inhibitor attenuates airway inflammation in asthmatic mouse model.
18411230	Cardiovasc. Res.	2008	Dueñas AI et al.	Selective attenuation of Toll-like receptor 2 signalling may explain the atheroprotective effect of sphingosine 1-phosphate.
15735657	Br. J. Pharmacol.	2005	Lindner K et al.	Ceramide alters endothelial cell permeability by a nonapoptotic mechanism.
15761190	Arterioscler. Thromb. Vasc. Biol.	2005	Bolick DT et al.	Sphingosine-1-phosphate prevents tumor necrosis factor-{alpha}-mediated monocyte adhesion to aortic endothelium in mice.
15764837	J. Pharmacol. Sci.	2005	Im YJ et al.	Study on action mode of sphingosine 1-phosphate in rat hepatocytes.
14982946	J. Leukoc. Biol.	2004	Goetzl EJ and Gräler MH	Sphingosine 1-phosphate and its type 1 G protein-coupled receptor: trophic support and functional regulation of T lymphocytes.
15044318	Circ. Res.	2004	Tanimoto T et al.	Sphingosine 1-phosphate transactivates the platelet-derived growth factor beta receptor and epidermal growth factor receptor in vascular smooth muscle cells.
16234413	J. Pharmacol. Exp. Ther.	2006	di Villa Bianca Rd et al.	Sphingosine 1-phosphate induces endothelial nitric-oxide synthase activation through phosphorylation in human corpus cavernosum.
16081668	Stem Cells	2005 Nov-Dec	Pébay A et al.	Essential roles of sphingosine-1-phosphate and platelet-derived growth factor in the maintenance of human embryonic stem cells.
16116182	J. Immunol.	2005	Czeloth N et al.	Sphingosine-1-phosphate mediates migration of mature dendritic cells.
15689381	Development	2005	Edsbagge J et al.	Vascular function and sphingosine-1-phosphate regulate development of the dorsal pancreatic mesenchyme.
15703400	J. Neurosci.	2005	Jaillard C et al.	Edg8/S1P5: an oligodendroglial receptor with dual function on process retraction and cell survival.
15710421	FEBS Lett.	2005	Geoffroy K et al.	Glomerular proliferation during early stages of diabetic nephropathy is associated with local increase of sphingosine-1-phosphate levels.
15870184	Blood	2005	Halin C et al.	The S1P-analog FTY720 differentially modulates T-cell homing via HEV: T-cell-expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer patches.
15881228	J Oral Sci	2005	Takeshita A et al.	Sphingosine 1-phosphate acts as a signal molecule in ceramide signal transduction of TNF-alpha-induced activator protein-1 in osteoblastic cell line MC3T3-E1 cells.
15975516	Chem. Biol.	2005	Jo E et al.	S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate.
15987639	FEBS Lett.	2005	Zaslavsky A et al.	Sphingosine-1-phosphate induces a PDGFR-dependent cell detachment via inhibiting beta1 integrin in HEK293 cells.
16996023	Biochim. Biophys. Acta	2006	Hait NC et al.	Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases.
16960101	Circ. Res.	2006	Whetzel AM et al.	Sphingosine-1 phosphate prevents monocyte/endothelial interactions in type 1 diabetic NOD mice through activation of the S1P1 receptor.
16931773	Stem Cells	2006	Meriane M et al.	Cooperation of matrix metalloproteinases with the RhoA/Rho kinase and mitogen-activated protein kinase kinase-1/extracellular signal-regulated kinase signaling pathways is required for the sphingosine-1-phosphate-induced mobilization of marrow-derived stromal cells.
16508938	Arthritis Rheum.	2006	Kitano M et al.	Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: regulation of synovial proliferation and inflammatory gene expression.
17080194	J. Clin. Invest.	2006	Idzko M et al.	Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.
17124500	EMBO J.	2006	Ryu J et al.	Sphingosine 1-phosphate as a regulator of osteoclast differentiation and osteoclast-osteoblast coupling.
17161984	Biochim. Biophys. Acta	2006	Taha TA et al.	A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell death.
17158340	Circ. Res.	2007	Pchejetski D et al.	Oxidative stress-dependent sphingosine kinase-1 inhibition mediates monoamine oxidase A-associated cardiac cell apoptosis.
17105828	J. Pharmacol. Exp. Ther.	2007	Kume H et al.	Sphingosine 1-phosphate causes airway hyper-reactivity by rho-mediated myosin phosphatase inactivation.
16542647	Cardiovasc. Res.	2006	Schubert R	Sphingosine-1-phosphate in the circulatory system: Cause and therapeutic target for vascular dysfunction?
16632640	J. Pharmacol. Exp. Ther.	2006	French KJ et al.	Antitumor activity of sphingosine kinase inhibitors.
16530698	Cancer Cell	2006	Milstien S and Spiegel S	Targeting sphingosine-1-phosphate: a novel avenue for cancer therapeutics.
16530706	Cancer Cell	2006	Visentin B et al.	Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages.
16782891	Mol. Cell. Biol.	2006	Giussani P et al.	Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide.
16769764	J. Leukoc. Biol.	2006	Oz-Arslan D et al.	IL-6 and IL-8 release is mediated via multiple signaling pathways after stimulating dendritic cells with lysophospholipids.
16815030	Trends Endocrinol. Metab.	2006	Garbers DL et al.	Membrane guanylyl cyclase receptors: an update.
16623665	Biochem. J.	2006	Venkataraman K et al.	Extracellular export of sphingosine kinase-1a contributes to the vascular S1P gradient.
16675717	Circ. Res.	2006	Xu SZ et al.	A sphingosine-1-phosphate-activated calcium channel controlling vascular smooth muscle cell motility.
16682747	J. Lipid Res.	2006	Jiang X and Han X	Characterization and direct quantitation of sphingoid base-1-phosphates from lipid extracts: a shotgun lipidomics approach.
16723416	J. Neurophysiol.	2006	Zhang YH et al.	Sphingosine-1-phosphate via activation of a G-protein-coupled receptor(s) enhances the excitability of rat sensory neurons.
16602758	Biomacromolecules	2006	Wacker BK et al.	Delivery of sphingosine 1-phosphate from poly(ethylene glycol) hydrogels.
16151014	Science	2005	Schwab SR et al.	Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients.
16199931	Kobe J Med Sci	2005	Urata Y et al.	Sphingosine 1-phosphate induces alpha-smooth muscle actin expression in lung fibroblasts via Rho-kinase.
17234743	Blood	2007	Kunisawa J et al.	Sphingosine 1-phosphate regulates peritoneal B-cell trafficking for subsequent intestinal IgA production.
17220911	Br. J. Pharmacol.	2007	Igarashi J et al.	Statins induce S1P1 receptors and enhance endothelial nitric oxide production in response to high-density lipoproteins.
17204658	Circ. Res.	2007	Maceyka M et al.	Shooting the messenger: oxidative stress regulates sphingosine-1-phosphate.
17210631	Mol. Cell Proteomics	2007	Guo Y et al.	Quantitative proteomics analysis of human endothelial cell membrane rafts: evidence of MARCKS and MRP regulation in the sphingosine 1-phosphate-induced barrier enhancement.
18502815	Am. J. Physiol. Lung Cell Mol. Physiol.	2008	Chen LY et al.	Cytosolic phospholipase A2alpha activation induced by S1P is mediated by the S1P3 receptor in lung epithelial cells.
18552276	Pharmacol. Rev.	2008	Takabe K et al.	"Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets.
18691012	Curr Drug Targets	2008	Zeidan YH et al.	Molecular targeting of acid ceramidase: implications to cancer therapy.
18521956	Eur. J. Immunol.	2008	Jin YZ et al.	Reciprocal function of Galphai2 and Galphai3 in graft-versus-host disease.
18638568	Biochim. Biophys. Acta	2008	Lynch KR and Macdonald TL	Sphingosine 1-phosphate chemical biology.
18658144	J. Lipid Res.	2008	Zhao C et al.	Specific and overlapping sphingosine-1-phosphate receptor functions in human synoviocytes: impact of TNF-alpha.
18781584	J. Cell. Physiol.	2009	Xie B et al.	Blockade of sphingosine-1-phosphate reduces macrophage influx and retinal and choroidal neovascularization.
18787560	Nat. Rev. Immunol.	2008	Rivera J et al.	The alliance of sphingosine-1-phosphate and its receptors in immunity.
18558630	Cardiovasc. Res.	2008	Heller R et al.	Overlapping and distinct roles for PI3Kbeta and gamma isoforms in S1P-induced migration of human and mouse endothelial cells.
18751921	Subcell. Biochem.	2008	Saddoughi SA et al.	Roles of bioactive sphingolipids in cancer biology and therapeutics.
17947659	J. Immunol.	2007	Czeloth N et al.	Sphingosine-1 phosphate signaling regulates positioning of dendritic cells within the spleen.
18819934	Mol. Cancer Res.	2008	Bryan L et al.	Sphingosine-1-phosphate and interleukin-1 independently regulate plasminogen activator inhibitor-1 and urokinase-type plasminogen activator receptor expression in glioblastoma cells: implications for invasiveness.
22532844	PLoS ONE	2012	Lim M et al.	The role of sphingosine kinase 1/sphingosine-1-phosphate pathway in the myogenic tone of posterior cerebral arteries.
22533672	Biochem. J.	2012	Lynch KR	Building a better sphingosine kinase-1 inhibitor.
22534621	Circulation	2012	Meissner A et al.	Tumor necrosis factor-α-mediated downregulation of the cystic fibrosis transmembrane conductance regulator drives pathological sphingosine-1-phosphate signaling in a mouse model of heart failure.
21940944	Arterioscler. Thromb. Vasc. Biol.	2011	McGuire PG et al.	Pericyte-derived sphingosine 1-phosphate induces the expression of adhesion proteins and modulates the retinal endothelial cell barrier.
21946553	J. Glaucoma	2013	Lukowski ZL et al.	Prevention of ocular scarring after glaucoma filtering surgery using the monoclonal antibody LT1009 (Sonepcizumab) in a rabbit model.
22019450	Biochim. Biophys. Acta	2012	Castillo-Badillo JA et al.	Sphingosine 1-phosphate-mediated α1B-adrenoceptor desensitization and phosphorylation. Direct and paracrine/autocrine actions.
22326262	Biochem. Biophys. Res. Commun.	2012	Takeshita H et al.	Sphingosine 1-phosphate (S1P)/S1P receptor 1 signaling regulates receptor activator of NF-κB ligand (RANKL) expression in rheumatoid arthritis.
22344462	Int. J. Oncol.	2012	Hsu A et al.	Sphingosine-1-phosphate receptor-3 signaling up-regulates epidermal growth factor receptor and enhances epidermal growth factor receptor-mediated carcinogenic activities in cultured lung adenocarcinoma cells.
22939756	J. Allergy Clin. Immunol.	2013	Price MM et al.	A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell-dependent murine model of allergic asthma.
22986288	Biochim. Biophys. Acta	2013	Xiang SY et al.	Lysophospholipid receptor activation of RhoA and lipid signaling pathways.
22203054	Am. J. Pathol.	2012	Armstrong SM et al.	Co-regulation of transcellular and paracellular leak across microvascular endothelium by dynamin and Rac.
22761247	J Zhejiang Univ Sci B	2012	Zhang BL et al.	Sphingosine 1-phosphate acts as an activator for the porcine Gpr3 of constitutively active G protein-coupled receptors.
22664872	J. Immunol.	2012	Nijnik A et al.	The role of sphingosine-1-phosphate transporter Spns2 in immune system function.
22865384	Am. J. Physiol. Heart Circ. Physiol.	2012	Curry FE et al.	Erythrocyte-derived sphingosine-1-phosphate stabilizes basal hydraulic conductivity and solute permeability in rat microvessels.
22848628	PLoS ONE	2012	Liu Q et al.	Inhibition of sphingosine kinase-2 suppresses inflammation and attenuates graft injury after liver transplantation in rats.
23793475	Reprod Sci	2014	Tsai YC et al.	Antiapoptotic agent sphingosine-1-phosphate protects vitrified murine ovarian grafts.
23615526	Mol. Cancer Res.	2013	Schneider G et al.	Bioactive lipids S1P and C1P are prometastatic factors in human rhabdomyosarcoma, and their tissue levels increase in response to radio/chemotherapy.
23658376	Cardiovasc. Res.	2013	Böhm A et al.	Factor-Xa-induced mitogenesis and migration require sphingosine kinase activity and S1P formation in human vascular smooth muscle cells.
23326540	PLoS ONE	2013	Yasuo M et al.	Fenretinide causes emphysema, which is prevented by sphingosine 1-phoshate.
23372844	PLoS ONE	2013	Finley A et al.	Sphingosine 1-phosphate mediates hyperalgesia via a neutrophil-dependent mechanism.
23145172	PLoS ONE	2012	Japtok L et al.	Sphingosine 1-phosphate modulates antigen capture by murine Langerhans cells via the S1P2 receptor subtype.
23150617	Invest. Ophthalmol. Vis. Sci.	2012	Qiao Y et al.	Sphingosine 1-phosphate elicits proinflammatory responses in ARPE-19 cells.
23103166	Cell Rep	2012	Mendoza A et al.	The transporter Spns2 is required for secretion of lymph but not plasma sphingosine-1-phosphate.
23180720	Cardiovasc. Res.	2013	Lidington D et al.	Capitalizing on diversity: an integrative approach towards the multiplicity of cellular mechanisms underlying myogenic responsiveness.
23171898	Med Sci (Paris)	2012	Cuvillier O	[Sphingosine 1-phosphate receptors: from biology to physiopathology].
23569284	Proc. Natl. Acad. Sci. U.S.A.	2013	Nguyen DH et al.	Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro.
23749868	Cancer Epidemiol. Biomarkers Prev.	2013	Alberg AJ et al.	Plasma sphingolipids and lung cancer: a population-based, nested case-control study.
23723371	Arterioscler. Thromb. Vasc. Biol.	2013	Tatematsu S et al.	Endothelial lipase is a critical determinant of high-density lipoprotein-stimulated sphingosine 1-phosphate-dependent signaling in vascular endothelium.
24001716	Hum. Reprod.	2013	Zhang J et al.	Sphingosine signalling regulates decidual NK cell angiogenic phenotype and trophoblast migration.
24285115	Am. J. Physiol. Heart Circ. Physiol.	2014	Zeng Y et al.	Sphingosine-1-phosphate protects endothelial glycocalyx by inhibiting syndecan-1 shedding.
24235134	Blood	2014	Speak AO et al.	Altered distribution and function of natural killer cells in murine and human Niemann-Pick disease type C1.
23863409	Biol. Reprod.	2013	Kotani T et al.	Altered expression of enzymes regulating the activity of endothelin-1 in the lower segment of the human amnion during labor.
24140934	Mol. Cancer Ther.	2014	Qin Z et al.	Targeting sphingosine kinase induces apoptosis and tumor regression for KSHV-associated primary effusion lymphoma.
23333075	Immunity	2013	Cortez-Retamozo V et al.	Angiotensin II drives the production of tumor-promoting macrophages.
24385389	J. Pharmacol. Exp. Ther.	2014	Miller DS	Sphingolipid signaling reduces basal P-glycoprotein activity in renal proximal tubule.
24516133	Proc. Natl. Acad. Sci. U.S.A.	2014	Ito K et al.	Integrin α9 on lymphatic endothelial cells regulates lymphocyte egress.
24221908	Hum. Reprod.	2014	Li F et al.	Sphingosine-1-phosphate prevents chemotherapy-induced human primordial follicle death.
24259678	J. Pharmacol. Exp. Ther.	2014	Emery SM et al.	Combined antiproliferative effects of the aminoalkylindole WIN55,212-2 and radiation in breast cancer cells.
23904439	J. Leukoc. Biol.	2013	Olivera A et al.	Sphingosine-1-phosphate can promote mast cell hyper-reactivity through regulation of contactin-4 expression.
18367532	J. Virol.	2008	Gavrilovskaya IN et al.	Hantaviruses direct endothelial cell permeability by sensitizing cells to the vascular permeability factor VEGF, while angiopoietin 1 and sphingosine 1-phosphate inhibit hantavirus-directed permeability.
22784711	Mol. Cancer Ther.	2012	Brizuela L et al.	First evidence of sphingosine 1-phosphate lyase protein expression and activity downregulation in human neoplasm: implication for resistance to therapeutics in prostate cancer.
24346695	Development	2014	Mendelson K et al.	Sphingosine 1-phosphate signalling.
24345679	Sci Signal	2013	Xiang SY et al.	PLCε, PKD1, and SSH1L transduce RhoA signaling to protect mitochondria from oxidative stress in the heart.
16357178	Cancer Res.	2005	Pchejetski D et al.	Sphingosine kinase-1 as a chemotherapy sensor in prostate adenocarcinoma cell and mouse models.